Radio-mitigation properties of α-lipoic acid when used alone and in combination with metformin or ethylmethylhydroxypyridine succinate (mexidol) in mice after exposure to X-ray radiation

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This study explored the radio-mitigation properties of α-lipoic acid and combination of α-lipoic acid with metformin and mexidol in animals during the process of X-ray irradiation. The results of the micronucleus test for measuring radiation-induced DNA damage of polychromatophilic red blood cells in the bone marrow of mice showed that α-lipoic acid has gene-protective and radio-mitigation properties in vivo. A study on the survival rate of the lethal dose-irradiated mice within 30 days confirmed that α-lipoic acid has radio-mitigation properties. The radio-mitigation effect of α-lipoic acid is dose-dependent, the effect increases with decreasing dose. α-lipoic acid in combination with mexidol and metformin exhibited a weaker radio-mitigation effect.

作者简介

E. Karmanova

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences;Institute of Cell Biophysics, Russian Academy of Sciences

Email: silisti@bk.ru
Pushchino, Moscow Region, Russia

A. Chernikov

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: silisti@bk.ru
Pushchino, Moscow Region, Russia

A. Usacheva

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: silisti@bk.ru
Pushchino, Moscow Region, Russia

V. Bruskov

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: silisti@bk.ru
Pushchino, Moscow Region, Russia

参考

  1. С. В. Гудков, Н. Р. Попова и В. И. Брусков, Биофизика, 60 (4), 801 (2015).
  2. E. Obrador, R. Salvador, J. I. Villaescusa, et al., Biomedicines, 8, 461 (2020).
  3. M. Srinivasan, N. Devipriya, K. B. Kalpana, and V. Menon, Toxicology, 262, 43 (2009).
  4. M. Cheki, A. Shirazi, A. Mahmoudzadeh, et al., Mut. Res. Gen. Toxicol. Environ. Mutagenesis, 809, 24 (2016).
  5. V. I. Bruskov, A. V. Chernikov, V. E. Ivanov, et al., Physics of Wave Phenomena, 28 (2), 91 (2020).
  6. V. I. Bruskov, E. E. Karmanova, A. V. Chernikov, et al., Physics of Wave Phenomena 29 (2), 94 (2021).
  7. K. P. Shay, R. F. Moreau, E. J. Smith, et al., Biochim. Biophys. Acta, 1790 (10), 1149 (2009).
  8. U. Cakatay, Med. Hypotheses, 66 (1), 110 (2006).
  9. C. Waslo, D. Bourdette, N. Gray, et al., Curr. Treat. Options Neurol., 21 (6), 26 (2019).
  10. Л. Ю. Моргунов, Мед. совет, 17, 90 (2014).
  11. О. В. Курушина, А. Е. Барулин и Е. П. Черноволенко, Мед. совет 1, 58 (2019).
  12. С. Ю. Калинченко, Л. О. Ворслов, И. А. Тюзиков и др., Фарматека, 6 (279), 43 (2014).
  13. Y. Wang, N. Everaert, Z. Song, et al., Comp. Biochem. Physiol. A: Mol.Integr. Physiol., 211, 34 (2017).
  14. L. Zhou and Y. Cheng, Neuropharmacology, 155, 98 (2019).
  15. S. Salinthone, V. Yadav, R. V. Schillace, et al., PLoS One, 5 (9), e13058 (2010).
  16. J. K. Lee, D. Samanta, H. G. Nam, and R. N. Zare, J. Am. Chem. Soc., 141 (27), 10585 (2019).
  17. Y. Koriyama, Y. Nakayama, S. Matsugo, and S. Kato, Brain Res., 1499, 145 (2013).
  18. S. Saboori, E. Falahi, E. Eslampour, et al., Nutr. Metab. Cardiovasc. Dis., 28(8), 779 (2018).
  19. M. Rahimlou, M. Asadi, N. B. Jahromi, and A. Mansoori, Clin. Nutr. ESPEN, 32, 16 (2019).
  20. S. L. Brown, A. Kolozsvary, J. Liu, et al., Radiat Res., 173 (4), 462 (2010).
  21. L. Ramachandran, C. Krishnan, and K. Nair, Mut. Res. Gen. Toxicol. Environ. Mutagenesis 724, 52 (2011).
  22. S. H. Ryu, E. Y. Park, S. Kwak, et al., Oncotarget, 7 (13), 15554 (2016).
  23. R. S. Said, A. Mohamed and D. H. Kassem, Toxicology, 442, 152536 (2020).
  24. Е. Е. Карманова, А. В. Черников, А. М. Усачева и В. И. Брусков, Хим.-фармацевт. журн., 56 (3), 3 (2022).
  25. Т. А. Воронина, Рос. мед. журн., 24 (7), 434 (2016).
  26. Л. А. Балыкова, А. В. Сипров, В. И. Инчина и др., Вестн. "Биомедицина и Социология", 6 (3), 4 (2021).
  27. M. Ostrovskyi, ScienceRise: Med. Sci., 3 (42), 20 (2021).
  28. А. Н. Гребенюк, В. А. Башарин, Р. А. Тарумов и др., Вестн. Росс. воен.-мед. акад., 1 (41), 102 (2013).
  29. K. Mortezaee, D. Shabeeb, A. E. Musa, et al., Cur. Clin. Pharm., 14 (1), 41 (2019).
  30. V. Piskovatska, K. B. Storey, A. M. Vaiserman, and O. Lushchak, in Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology, v. 1260, Ed. By P. Guest (Springer, Cham. 2020), pp. 319-332.
  31. E. E. Karmanova, S. A. Abdullaev, V. E. Ivanov, et al., IOP Conf. Ser. Mat. Sci. Eng. 487, 012023 (2019).
  32. Е. Е. Карманова, А. В. Черников, А. М. Усачева и В. И. Брусков, Хим.-фармацевт. журн., 54 (7), 10 (2020).
  33. A. Vral, M. Fenech, and H. Thierens, Mutagenesis, 26 (1), 11 (2011).
  34. N. R. Asadullina, A. M. Usacheva, V. S. Smirnova and S. V. Gudkov, Nucleosides, Nucleotides and Nucleic Acids, 29, 786 (2010).
  35. A. Piechota-Polanczyk, M. Zielinska, D. Piekielny, and J. Fichna, Biomed. Pharmacother., 84, 470 (2016).
  36. А. М. Усачева, А. В. Черников, Е. Е. Карманова и В. И. Брусков, Хим.-фармацевт. журн., 55 (11), 9 (2021).
  37. N. S. Chandel, BMC Biology, 12, 34 (2014).
  38. D. C. Henstridge, M. Whitham, and M. A. Febbraio, Mol. Metabol., 3, 781 (2014).
  39. I. N. Todorov, Ros. Khimich. Zhurn., 51, 93 (2007).
  40. L. Rochette, G. Steliana, R. Carole, et al., Mol. Nutr. Food Res., 57, 114 (2013).
  41. S. Dragomanova, S. Miteva, F. Nicoletti, et al., Antioxidants, 10, 1294 (2021).
  42. M. R. Owen, E. Doran, and A. P. Halestrap, Biochem. J., 348, 607 (2000).
  43. M.-Y. El-Mir, V. Nogueira, E. Fontaine, et al., J. Biol. Chem., 275, 223 (2000).
  44. Г. В. Бузник, В. В. Востриков и П. Д. Шабанов, Вестн. Смоленской гос. мед. академии, 19 (4), 22 (2020).
  45. Н. А. Жаркинбекова, Медицина (Алматы), 3-4, 64 (2020).
  46. R. Yahyapour, P. Amini, H. Saffar, et al., Cur. Drug Res. Rev., 11, 111 (2019).
  47. И. Ю. Торшин, О. А. Громова, И. С. Сардарян и др., Фармакокинетика и фармакодинамика, № 4, 19 (2016).

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