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Nitro-Substituted Pyridinimine Complexes of Pd(II): Synthesis and Inhibition of MAO-B ex vivo

Dublin Core		PKP Metadata Items	Metadata for this Document
1.	Title	Title of document	Nitro-Substituted Pyridinimine Complexes of Pd(II): Synthesis and Inhibition of MAO-B ex vivo
2.	Creator	Author's name, affiliation, country	M. S. Denisov; Institute of Technical Chemistry of Ural Branch of the RAS, Perm, Russia
2.	Creator	Author's name, affiliation, country	Yu. A. Beloglazova; Institute of Technical Chemistry of Ural Branch of the RAS, Perm, Russia
3.	Subject	Discipline(s)
3.	Subject	Keyword(s)	palladium; MAO; pyridinimine complexes; nitroaniline; Schiff base
4.	Description	Abstract	The first ever synthesis of complexes [PdLCl2] (I) and [PdLBr2] (II) was successfully achieved, where L = 2,6-dimethyl-4-nitro-N-(pyridin-2-ylmethylildene)aniline, a ligand with a purported ability to inhibit monoamine oxidase B (MAO-B). To gain insight into the molecular structure of complexes I and II, as well as the ligand precursor 2,6-dimethyl-4-nitroaniline L4 (CIF files CCDC nos. 2255106 (I), 2255105 (II), 2255103 (L), 2255104 (L4)), X-ray diffraction analysis was utilized. Complex I underwent further characterization to determine its stability, solubility, and lipophilicity. Cytotoxicity studies of substances L, I, and II on human embryonic kidney cell line HEK-293 showed no evidence of cytotoxic activity. To evaluate the inhibitory activity of new substances L, I, and II as well as established substances III−IX, selegiline, and rasagiline, ex vivo studies were conducted, establishing a structure/activity relationship.
5.	Publisher	Organizing agency, location	The Russian Academy of Sciences
6.	Contributor	Sponsor(s)
7.	Date	(DD-MM-YYYY)	01.09.2023
8.	Type	Status & genre	Peer-reviewed Article
8.	Type	Type	Unknown
9.	Format	File format
10.	Identifier	Uniform Resource Identifier	https://rjdentistry.com/0132-344X/article/view/667482
10.	Identifier	Digital Object Identifier (DOI)	10.31857/S0132344X23600066
10.	Identifier	eLIBRARY Document Number (EDN)	WBEBFO
11.	Source	Title; vol., no. (year)	Koordinacionnaâ himiâ; Vol 49, No 9 (2023)
12.	Language	English=en
13.	Relation	Supp. Files	(78KB) (307KB) (51KB) (290KB) (27KB) (52KB) (336KB) (383KB) (84KB)
14.	Coverage	Geo-spatial location, chronological period, research sample (gender, age, etc.)
15.	Rights	Copyright and permissions	Copyright (c) 2023 М.С. Денисов, Ю.А. Белоглазова