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AgeMeta: QUANTITATIVE GENE EXPRESSION DATABASE OF MAMMALIAN AGING

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1. Title Title of document AgeMeta: QUANTITATIVE GENE EXPRESSION DATABASE OF MAMMALIAN AGING
2. Creator Author's name, affiliation, country S. A Tikhonov; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University
2. Creator Author's name, affiliation, country M. A Batin; Open Longevity
2. Creator Author's name, affiliation, country V. N Gladyshev; Brigham and Women’s Hospital, Harvard Medical School
2. Creator Author's name, affiliation, country S. E Dmitriev; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University
2. Creator Author's name, affiliation, country A. E Tyshkovskiy; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University; Brigham and Women’s Hospital, Harvard Medical School
3. Subject Discipline(s)
3. Subject Keyword(s) AgeMeta; age-meta; GSEA; aging; ageing; gene expression; differential expression; transcriptomics; mammalian; meta-analysis; AgeMeta; age-meta; database; GSEA
4. Description Abstract AgeMeta is a database that provides systemic and quantitative description of mammalian aging at the level of gene expression. It encompasses transcriptomic changes with age across various tissues of humans, mice, and rats, based on a comprehensive meta-analysis of 122 publicly available gene expression datasets from 26 studies. AgeMeta provides an intuitive visual interface for quantification of aging-associated transcriptomics at the level of individual genes and functional groups of genes, allowing easy comparison among various species and tissues. Additionally, all the data in the database can be downloaded and analyzed independently. Overall, this work contributes to the understanding of the complex network of biological processes underlying mammalian aging and supports future advancements in this field. AgeMeta is freely available at: https://age-meta.com/.
5. Publisher Organizing agency, location The Russian Academy of Sciences
6. Contributor Sponsor(s)
7. Date (DD-MM-YYYY) 15.12.2024
8. Type Status & genre Peer-reviewed Article
8. Type Type Research Article
9. Format File format
10. Identifier Uniform Resource Identifier https://rjdentistry.com/0320-9725/article/view/665796
10. Identifier Digital Object Identifier (DOI) 10.31857/S0320972524020099MHQEG
10. Identifier eLIBRARY Document Number (EDN) XMHQEG
11. Source Title; vol., no. (year) Biohimiâ; Vol 89, No 2 (2024)
12. Language English=en ru
13. Relation Supp. Files
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
15. Rights Copyright and permissions Copyright (c) 2024 Russian Academy of Sciences