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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Dentistry</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Dentistry</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский стоматологический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-2802</issn><issn publication-format="electronic">2413-2934</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">217214</article-id><article-id pub-id-type="doi">10.17816/dent217214</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Experimental and Theoretical Investigations</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Экспериментально-теоретические исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Influence of soft tissue on the reparative abilities of the jaw bone tissue in patients with dentoalveolar lesions</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние мягких тканей, выстилающих дефект кости челюсти, на репаративный остеогенез при дентоальвеолярных поражениях</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2759-135X</contrib-id><contrib-id contrib-id-type="spin">4507-6276</contrib-id><name-alternatives><name xml:lang="en"><surname>Slesarev</surname><given-names>Oleg V.</given-names></name><name xml:lang="ru"><surname>Слесарев</surname><given-names>Олег Валентинович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>д.м.н., доцент</p></bio><email>o.slesarev@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9077-2888</contrib-id><contrib-id contrib-id-type="spin">2588-2812</contrib-id><name-alternatives><name xml:lang="en"><surname>Malchikova</surname><given-names>Darya V.</given-names></name><name xml:lang="ru"><surname>Мальчикова</surname><given-names>Дарья Вячеславовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Postgraduate</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>dvmalchikova@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0026-309X</contrib-id><contrib-id contrib-id-type="spin">8808-4658</contrib-id><name-alternatives><name xml:lang="en"><surname>Yunusova</surname><given-names>Yuliya R.</given-names></name><name xml:lang="ru"><surname>Юнусова</surname><given-names>Юлия Рафаильевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент</p></bio><email>kaf_patanat@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8318-0355</contrib-id><contrib-id contrib-id-type="spin">1805-0892</contrib-id><name-alternatives><name xml:lang="en"><surname>Kulakova</surname><given-names>Olesia V.</given-names></name><name xml:lang="ru"><surname>Кулакова</surname><given-names>Олеся Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент</p></bio><email>olesvk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7453-3120</contrib-id><contrib-id contrib-id-type="spin">2100-4649</contrib-id><name-alternatives><name xml:lang="en"><surname>Nefedova</surname><given-names>Irina F.</given-names></name><name xml:lang="ru"><surname>Нефёдова</surname><given-names>Ирина Феликсовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Сhief Specialist of Center for Biomedical Cell Products of NTI “Bionic engineering in Medicine”</p></bio><bio xml:lang="ru"><p>главный специалист центра биомедицинских клеточных продуктов НТИ «Бионическая инженерия в медицине»</p></bio><email>i.f.nefedova@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5167-6479</contrib-id><name-alternatives><name xml:lang="en"><surname>Belanov</surname><given-names>Vyacheslav G.</given-names></name><name xml:lang="ru"><surname>Беланов</surname><given-names>Вячеслав Геннадьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Resident</p></bio><bio xml:lang="ru"><p>ординатор</p></bio><email>slava.belanov@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">Самарский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-05-11" publication-format="electronic"><day>11</day><month>05</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-08-21" publication-format="electronic"><day>21</day><month>08</month><year>2023</year></pub-date><volume>27</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>111</fpage><lpage>119</lpage><history><date date-type="received" iso-8601-date="2023-02-10"><day>10</day><month>02</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-05-11"><day>11</day><month>05</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2026-08-21"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjdentistry.com/1728-2802/article/view/217214">https://rjdentistry.com/1728-2802/article/view/217214</self-uri><abstract xml:lang="en"><p><bold><italic>BACKGROUND:</italic></bold> Treating patients with a jaw bone defect requires eliminating the defect, restoring dentition, and providing long-term support for the functional state of the dental system. However, dental damage reduces the reparative capabilities of the jaw bone tissue. Therefore, when developing ways to repair such defects, the proportion of soft tissue in the bone defect must be determined.</p> <p><bold><italic>AIM:</italic></bold> To study the effect of soft-tissue elements on the reparative abilities of jaw bone tissue.</p> <p><bold><italic>MATERIALS AND METHODS:</italic></bold> This study included 98 people with acquired combined jaw bone defects. The material was taken during a surgical intervention to study the tissue environment and the characteristics of the transformation of the tissues surrounding the defect. The samples were sent for histological examination.</p> <p><bold><italic>RESULTS:</italic></bold> Microscopic examination of the histological sections obtained from the area of the jaw bone defects revealed the proliferation of a multilayer flat non-corneating epithelium with “creeping” and massive ingrowth of the epithelium into the area of the bone defect. The epithelium had advanced into the underlying bone, which led to atrophy and destruction of the bone over the entire area of the defect, increasing the volume of the defect. An epithelial-connective tissue complex lined the bone surface of the defect, replacing the periosteum.</p> <p><bold><italic>CONCLUSIONS:</italic></bold> The morphology of the tissues surrounding the area of a bone defect suggests a decrease in cambial bone elements. Treating jaws with bone defects requires eliminating the soft tissue that fills the bone defect, followed by guided bone regeneration using a granular osteoconductive graft and a resorbable collagen membrane.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование. </bold>Лечение пациентов с костными дефектами челюстей требует устранения дефекта, восстановления зубного ряда и долгосрочной поддержки функционального состояния зубочелюстной системы. Однако дентоальвеолярные поражения снижают репаративные возможности костной ткани челюстей. Поэтому при разработке способов оптимизации репаративного остеогенеза важной задачей является определение характера влияния мягких тканей на репаративный остеогенез дефекта кости челюстей.</p> <p><bold>Цель</bold> — изучить влияние мягких тканей, выстилающих дефект кости челюсти, на репаративный остеогенез.</p> <p><bold>Материал и методы.</bold> В исследование были включены 98 человек с приобретёнными сочетанными костными дефектами челюстей. Протокол лечения включал 2 этапа. На этапе диагностики и планирования устранения костных дефектов челюстей проводили прогностический расчёт необходимого объёма гранулированного костнопластического материала. На хирургическом этапе одномоментно проводили операции дентальной имплантации и направленной костной регенерации. Для изучения тканей, заполняющих дефект кости челюстей, осуществляли забор материала во время операции дентальной имплантации и после хирургического этапа по истечении срока остеоинтеграции дентальных имплантатов на этапе установки формирователя десны. Полученные образцы отправляли на гистологическое исследование, где их подготавливали по стандартной схеме, препараты окрашивали гематоксилином и эозином, а также пикрофуксином по Ван Гизону.</p> <p><bold>Результаты.</bold> При микроскопическом исследовании гистологических срезов, полученных из области костных дефектов челюстей, отмечали пролиферацию многослойного плоского неороговевающего эпителия с наползанием и массивным врастанием эпителия в область дефекта кости. Продвижение эпителия в подлежащую кость приводило к атрофии и деструкции кости по всей площади дефекта, увеличению объёма дефекта и формированию полостей, заполненных неоформленной соединительной тканью с мощными пучками коллагеновых волокон и выраженной инфильтрацией между ними. В результате морфологического исследования фрагмента костной ткани обнаружено, что поверхность материала окружена балками новообразованной костной ткани. Основные участки пролиферативной активности остеобластов обнаруживались на гранулах материала, на которых напластовалась новообразованная костная ткань.</p> <p><bold>Заключение. </bold>Морфология тканей, заполняющих область костного дефекта, позволяет судить о снижении источников камбиальных элементов кости. Лечение костных дефектов челюстей требует удаления мягких тканей, выстилающих костный дефект, с последующим проведением операции направленной костной регенерации с использованием гранулированного остеокондуктивного материала и резорбируемой коллагеновой мембраны.</p></trans-abstract><kwd-group xml:lang="en"><kwd>bone defect of the jaw</kwd><kwd>granular osteoconductive bone-plastic material</kwd><kwd>bone growth factors</kwd><kwd>directed bone regeneration</kwd><kwd>optimization of reparative osteogenesis</kwd><kwd>dentoalveolar lesions</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>костный дефект челюсти</kwd><kwd>гранулированный остеокондуктивный костнопластический материал</kwd><kwd>факторы роста кости</kwd><kwd>направленная костная регенерация</kwd><kwd>оптимизация репаративного остеогенеза</kwd><kwd>дентоальвеолярные поражения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Tan WL, Wong TL, Wong MC, Lang NP. 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