Russian Journal of DentistryRussian Journal of Dentistry1728-28022413-2934Eco-Vector3887210.17816/dent.38872The application of stomatological biofilms containing clindamycin and galavit for the combined treatment of chronic generalized periodontitisArutyunovSergey Darchoevicharutyunov@mail.ruTsarevV N-NikolaevaE N-UnanyanA A-MartirosyanV G-ArutyunovS D-TzarevV N-NikolaevaE N-UnanyanA A-MartirosyanV G-15022011151232621072020Copyright © 2011, Eco-Vector2011Stomatological biofilms Diplen K and Diplen G were used to treat patients presenting with chronic generalized periodontitis. The most characteristic general and local features of this pathological condition associated with type 1 periodontopathogenic bacteria were identified. It was shown that Diplen biofilms applied in combination with antibiotics clindamycin and immunomodulator galavit substantially suppress inflammatory reactions; moreover, they appear to reduce alteration of periodontal tissues. At the same time, clindamycin slows down the development and invasion of microorganisms which leads to a significant decrease in the number of the most aggressive anaerobic bacteria or their complete elimination; also, it strengthens the positive effect of the combined treatment. The patients reported the improvement of the overall health and needed no additional therapy.stomatological biofilmschronic generalized periodontitisстоматологические биопленкихронический генерализованный пародонтит[Подколзин А. А., Гришина Т. И. (ред.). Галавит: Клиническое использование и механизмы действия // Сб. науч. трудов. - М., 2002. - С. 55-62.][Царев В. Н., Ушаков Р. В., Плахтий Л. Я., Чухаджян Г. Ф. Применение адгезивных пленок "Диплен-дента" в комплексном лечении пародонтита: Метод. рекомендации. - М., 2002.][Царев В. Н., Николаева Е. Н. // Стоматология. - 2007. - № 5. - С. 82-87.][Чергештов Ю. И., Минин Е. В., Царева Т. В., Артемова В. О. // Стоматолог. - 2009. - № 5-6. - С. 28-39.][Янушевич О. О., Ушаков Р. В., Царев В. Н. Антимикробная терапия и профилактика осложнений воспалительных заболеваний пародонта: Учеб. пособие. - М., 2009][Chapple I. L. C. // Periodontology. - 2009. - Vol. 51, N 1. - P. 9-24.][Ellison S. J. // Br. Dent. J. - 2009. - Vol. 206, N 7. - P. 357-362.]