Russian Journal of DentistryRussian Journal of Dentistry1728-28022413-2934Eco-Vector3905510.17816/dent.39055Research ArticleTHE PROPERTIES OF THE GINGIVAL FLUID FROM THE PATIENTS PRESENTING WITH ACUTE GINGIVITIS AND CHRONIC PERIODONTITISTsybikovN. N-DomanovaE. T-ZobninV. V-IgnatovM. Yu-MasloE. Yumaslo_lena@list.ruIsakovaN. V-15022012161404221072020Copyright © 2012, Eco-Vector2012In the present study involving 30 patients presenting with acute catarrhal gingivitis and chronic periodontitis, we measured the levels of immunoglobulins (IgM, IgA, IgE, total IgG and its subclasses) and cytokines (IL-1-beta, IL-4, IL-6, IL-8, TNF-alpha); in addition, the absorption capacity and phagocytic activity of intact neutrophils were determined after their incubation with the gingival fluid. The latter ’s coagulative and fibrinolytic properties were studied. It was shown that exacerbation of gingivitis is associated with enhanced activity of the gingival fluid that in its turn leads to the increase of the phagocytic number and phagocytic index, the levels of IgM, IgA, and IgG subclasses, IL-6 and TNF-alpha concentration. The gigngival fluid obtained from the patients presenting with acute gingivitis suppressed phagocytosis. It is concluded that the elevated proinflammatory cytokine levels, increased coagulative capacity and decreased fibrinolytic activity of the gigngival fluid are the common characteristics of acute gingivitis and chronic periodontitis.gingival fluidgingivitisperiodontitisphagocytosisimmunoglobulinscytokinescoagulationfibrinolysisдесневая жидкостьгингивитпародонтитфагоцитозиммуноглобулиныцитокиныкоагуляцияфибринолиз[Барер Г. М. // Стоматология. - 1986. - № 4. - С. 86-90.][Барер Г. М., Григорян С. С. // Материалы Всероссийской науч.-практ. конф., посвящ. 105-летию со дня рожд. проф. E. Е. Платонова. - М., 2006. - С. 28-31.][Быкова Л. П., Калинин Д. В. // Рос. ринол. - 2009. - № 1. - С. 40-43.][Грудянов А. И., Дминтиева Л. А., Максимовский Ю. М. // Стоматология. - 1999. - № 1. - С. 47-48.][Дурново Е. А. // Стоматология. - 2005. - №3. - С. 29-32.][Есаян З. В. // Стоматология. - 2005. - № 1. - С. 58-64.][Момот А. П., Шойхет Я. Н. // Тромбоз, гемостаз и реол. - 2009. - № 37. - С. 23-38.][Шмидт Д. В., Шмагель К. В., Мозговая Л. А. // Стоматология. - 2008. - № 4. - С. 33-38.][Azuma M. J. // J. Periodontol. Res. - 2006. - Vol. 41. - P. 361-373.][Dominguez A., Gomez C., Garcia-Kass Al., Garcia-Nunez J. A. // Lasers Surg. Med. - 2010. - Vol. 42, № 1. - P. 24-31.][Higari A. A. // J. Biol. Chem. - 1996. - Vol. 271, № 30. - P. 1765017655.][Kurdowska A. K., Noble J. M., Adcock J. E. // J. Periodontol. Res. - 2003. - Vol. 38, № 1. - P. 73-78.][Tsai C. C., Ku C. H., Ho Y. P. et al. // J. Clin. Periodontol. - 2002. -Vol. 29. - P. 1023-1028.][Zaremba M., Gorska R. // J. Periodontol. - 2007. - Vol. 2. - P. 322327.][Yamamoto M., Saeki K., Utsumi K. // Arch. Biochem. Biophys. -1991. - Vol. 289, № 2. - P. 76-82.]