Russian Journal of DentistryRussian Journal of Dentistry1728-28022413-2934Eco-Vector4205010.18821/1728-28022016;20(6):301-304Research ArticleHistochemical characteristics of reparative dentinogenesis of the tooth pulpSirakSergey VladimirovichDr. med. Sciences, Professor, head. the Department of stomatology of the Stavropol state medical Universitysergejsirak@yandex.ruShchetininE. V-KobylkinaT. L-AdamchikA. A-SirakA. G-VafiadiM. Yu-Stavropol State Medical University Health Ministry of Russian FederationKuban State Medical University Health Ministry of Russian Federation1512201620630130404082020Copyright © 2016, Eco-Vector2016The role of C-kit-positive cells in the pulp of the tooth to optimize reparative dentinogenesis in biological methods of treatment of pulpitis in experimental animals were studied. In vivo 80 tooth of the lower jaw of sheep received a model of acute pulpitis with subsequent amputation of the vital pulp. Use as a biological method of treatment of tissue-engineered constructs composed of collagen sponge, hydrogel PuraMatrix/3DM and ectomesenchymal stem cells has allowed to better protect the pulp from infection, to optimize the inflammatory process with the activation of proliferation and acceleration of formation of dentinal bridge.pulpitistissue-engineered designectomesenchymal stem cellsпульпиттканеинженерная конструкцияэктомезенхимальные клетки[Сирак А.Г., Сирак С.В. Морфофункциональные изменения в пульпе зубов экспериментальных животных при лечении глубокого кариеса и острого очагового пульпита с использованием разработанных лекарственных композиций. Современные проблемы науки и образования. 2013; (2): 44.][Сирак А.Г., Сирак С.В. Динамика репаративного дентиногенеза после лечения глубокого кариеса и острого очагового пульпита разработанной поликомпонентной лечебной пастой. 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