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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Dentistry</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Dentistry</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский стоматологический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-2802</issn><issn publication-format="electronic">2413-2934</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">42072</article-id><article-id pub-id-type="doi">10.18821/1728-28022016;20(3):165-168</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Role nitrogen oxide and reactive nitrogen species in cancerogenesis of oral mucous membrane</article-title><trans-title-group xml:lang="ru"><trans-title>Роль оксида азота (II) и его активных метаболитов в канцерогенезе слизистой оболочки полости рта</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Baydik</surname><given-names>O. D</given-names></name><name xml:lang="ru"><surname>Байдик</surname><given-names>Ольга Дмитриевна</given-names></name></name-alternatives><bio xml:lang="en"><p>Dr. Sci. Med., Associate professor of the Department of Dentistry, “Siberian State Medical University”</p></bio><bio xml:lang="ru"><p>д-р мед. наук, доцент кафедры стоматологии Сибирского государственного медицинского университета</p></bio><email>olgabajdik@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Titarenko</surname><given-names>M. A</given-names></name><name xml:lang="ru"><surname>Титаренко</surname><given-names>М. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sysolyatin</surname><given-names>P. G</given-names></name><name xml:lang="ru"><surname>Сысолятин</surname><given-names>П. Г</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">”Siberian state medical University”</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Сибирский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">”Novosibirsk state medical University”</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Новосибирский государственный медицинский университет»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2016</year></pub-date><volume>20</volume><issue>3</issue><issue-title xml:lang="en">VOL 20, NO3 (2016)</issue-title><issue-title xml:lang="ru">ТОМ 20, №3 (2016)</issue-title><fpage>165</fpage><lpage>168</lpage><history><date date-type="received" iso-8601-date="2020-08-04"><day>04</day><month>08</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО "Эко-Вектор"</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjdentistry.com/1728-2802/article/view/42072">https://rjdentistry.com/1728-2802/article/view/42072</self-uri><abstract xml:lang="en"><p>Effects NO and reactive nitrogen species for screen method ofprecancer diseases of oral mucous membrane were presented, value of risk transformation in cancer in situ, drafting ofprognosis disease and expediency forfurther researches were showed in this point line.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлены эффекты NO и его активных метаболитов в качестве скринингового метода диагностики предраковых заболеваний слизистой оболочки полости рта, оценки риска трансформации в cancer in situ, для составления прогноза течения заболевания, а также показана целесообразность проведения дальнейших исследований в этом направлении.</p></trans-abstract><kwd-group xml:lang="en"><kwd>review</kwd><kwd>nitrogen oxide</kwd><kwd>apoptosis</kwd><kwd>antioxidant system</kwd><kwd>biomarkers</kwd><kwd>cancerogenesis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>оксид азота</kwd><kwd>апоптоз</kwd><kwd>антиоксидантная система</kwd><kwd>биомаркеры</kwd><kwd>канцерогенез</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Вавилова Т.П., Янушевич О.О., Островская И.Г. 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