<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Dentistry</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Dentistry</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский стоматологический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-2802</issn><issn publication-format="electronic">2413-2934</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">642237</article-id><article-id pub-id-type="doi">10.17816/dent642237</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical Investigations</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Scientific and practical evidence of the efficacy of various dentures in orthopedic dentistry in HIV-positive patients</article-title><trans-title-group xml:lang="ru"><trans-title>Научно-практическое обоснование эффективности разных видов зубных протезов для ортопедической стоматологической помощи ВИЧ-инфицированным пациентам</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-3443-0849</contrib-id><name-alternatives><name xml:lang="en"><surname>Pulatova</surname><given-names>Raykhon S.</given-names></name><name xml:lang="ru"><surname>Пулатова</surname><given-names>Райхон Саидумаровна</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><email>rayxonpulatova82@gmail.com</email></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2816-3162</contrib-id><contrib-id contrib-id-type="spin">9176-2861</contrib-id><name-alternatives><name xml:lang="en"><surname>Gafforov</surname><given-names>Sunnatullo A.</given-names></name><name xml:lang="ru"><surname>Гаффоров</surname><given-names>Суннатулло Амруллоевич</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>sunnatullogafforov@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2843-2070</contrib-id><name-alternatives><name xml:lang="en"><surname>Hen</surname><given-names>Dmitriy N.</given-names></name><name xml:lang="ru"><surname>Хен</surname><given-names>Дмитрий Николаевич</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><email>hdn75@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Bukhara State Medical Institute</institution></aff><aff><institution xml:lang="ru">Бухарский государственный медицинский институт имени Абу Али ибн Сино</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Center for the Development of Professional Qualification of Medical Workers</institution></aff><aff><institution xml:lang="ru">Центр развития профессиональной квалификации медицинских работников Министерства здравоохранения Республики Узбекистан</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-04-01" publication-format="electronic"><day>01</day><month>04</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-04-29" publication-format="electronic"><day>29</day><month>04</month><year>2025</year></pub-date><volume>29</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>150</fpage><lpage>160</lpage><history><date date-type="received" iso-8601-date="2024-12-02"><day>02</day><month>12</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2025-02-28"><day>28</day><month>02</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-04-29"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjdentistry.com/1728-2802/article/view/642237">https://rjdentistry.com/1728-2802/article/view/642237</self-uri><abstract xml:lang="en"><p><bold>Background:</bold> Dental care in HIV-positive patients is a significant problem. The clinical course of the disease, particularly the high risk of infection, along with social and psychological stress, makes the diagnosis and treatment difficult. This necessitates specialized dental care, including the use of modern dentures that improve the functional status of periodontal tissues, increase the stability of masticating pressure, and consider etiopathogenetic mechanisms.</p> <p><bold>Aim:</bold> To provide scientific and practical evidence of the efficacy of alternative denture designs in HIV-positive patients with specific clinical and morphological features of periodontal tissue and oral mucosa lesions.</p> <p><bold>Methods:</bold> The study included 384 HIV-positive patients (treatment group, TG) and 258 control subjects (control group, CG) who were followed up at the Republican AIDS Center and its Bukhara branch. Of these, 134 TG patients (TG-1), including 68 TG patients (TG-2) and 66 reference group (RG) patients, as well as 38 CG patients, received orthopedic treatment using various types of dentures. TG-2a (<italic>n</italic>=33) received thermoplastic monomer-free Vertex ThermoSens dentures, whereas TG-2b (<italic>n</italic>= 5) received Vertex ThermoSens dentures with the Gluma Comfort Bond adhesive for surface treatment; RG-1 (<italic>n=</italic>32) received Ftorax acrylic plastic dentures, whereas RG-2 (<italic>n=</italic>34) received Ftorax acrylic plastic dentures with the Gluma Comfort Bond adhesive for surface treatment. CG patients received Vertex ThermoSens dentures. The study subjects were followed up for 12 months; clinical, dental, laboratory, functional, and histomorphological examinations were performed.</p> <p><bold>Results:</bold> Taking into account the clinical features of oral lesions in HIV-positive patients, thermoplastic monomer-free Vertex ThermoSens dentures with the Gluma Comfort Bond adhesive were superior to Ftorax acrylic plastic dentures. However, considering the social and economic acceptability of Ftorax dentures, the use of the Gluma Comfort Bond adhesive is justified, eliminating the major shortcomings of currently used acrylic plastics.</p> <p><bold>Conclusion:</bold> A treatment and prevention algorithm for dental restoration has been developed for HIV-positive patients. The algorithm involves treating Vertex ThermoSens and Ftorax dentures with the Gluma Comfort Bond adhesive, which reduces periodontal tissue inflammation and improves masticatory efficiency.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Оказание стоматологической помощи ВИЧ-инфицированным пациентам представляет собой сложную проблему. Клиническое течение заболевания, особенно высокий риск инфицирования, формирование социального и психологического стресса у людей затрудняют диагностику и лечение. Возникает необходимость в специализированной стоматологической помощи — использовании современных зубных протезов, улучшающих функциональное состояние тканей пародонта, повышающих эффект устойчивости жевательного давления в зубных рядах и учитывающих этиопатогенетические механизмы.</p> <p><bold>Цель.</bold> Научно-практическое обоснование эффективности альтернативных конструкций зубных протезов при специфических клинико-морфологических особенностях патологий в тканях пародонта и слизистой оболочки полости рта у ВИЧ-инфицированных пациентов.</p> <p><bold>Материалы и методы.</bold> Исследованы 384 ВИЧ-инфицированных больных (основная группа, ОГ) и 258 человек контрольной группы (КГ), находящихся на учёте в Республиканском центре по борьбе со СПИДом и в его Бухарском филиале. 134 пациента из ОГ (ОГ-1), в том числе 68 человек (ОГ-2) и 66 человек группы сравнения (СГ), и 38 человек из КГ получали стоматологическую ортопедическую помощь с использованием разных видов протезов: ОГ-2а (<italic>n</italic>=33) — из безмономерной пластмассы для термопрессования Vertex ThermoSens и ОГ-2б (<italic>n</italic>=35) — из Vertex ThermoSens с экранированием поверхности протезов адгезивом Gluma Comfort Bond; СГ-1 (<italic>n</italic>=32) — из акриловой пластмассы «Фторакс» и СГ-2 (<italic>n</italic>=34) — из акриловой пластмассы «Фторакс» с экранированием адгезивной системой Gluma Comfort Bond. Для пациентов КГ использовали протезы из Vertex ThermoSens. Наблюдали состояние обследуемых в течение 12 мес, проводили клинико-стоматологические, лабораторные, функциональные и гистоморфологические исследования.</p> <p><bold>Результаты.</bold> С учётом клинических особенностей патологий тканей и органов полости рта у ВИЧ-инфицированных пациентов выявлено преимущество безмономерной пластмассы для термопрессования Vertex ThermoSens с экранированием адгезивом Gluma Comfort Bond над зубным протезом, изготовленным из акриловой пластмассы «Фторакс». В то же время, исходя из социально-экономической приемлемости протезов из «Фторакс», обосновано экранирование их адгезивом Gluma Comfort Bond, что нивелирует существенные недостатки, имеющиеся у применяемых в данное время акриловых пластмасс.</p> <p><bold>Заключение.</bold> Для ВИЧ-инфицированных пациентов разработан лечебно-профилактический алгоритм восстановления зубных рядов путём пропитки зубных протезов из Vertex ThermoSens и «Фторакс» адгезивом Gluma Comfort Bond, что уменьшает выраженность воспалительных процессов тканей пародонта и способствует повышению эффективности жевания.</p></trans-abstract><kwd-group xml:lang="en"><kwd>dental diseases</kwd><kwd>AIDS</kwd><kwd>HIV</kwd><kwd>periodontal tissue inflammation</kwd><kwd>dentistry</kwd><kwd>occlusion</kwd><kwd>dentures</kwd><kwd>oral mucosa</kwd><kwd>saliva composition</kwd><kwd>gnathodynamometry</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>стоматологические заболевания</kwd><kwd>СПИД</kwd><kwd>ВИЧ</kwd><kwd>воспаление тканей пародонта</kwd><kwd>стоматология</kwd><kwd>прикус</kwd><kwd>искусственные зубные протезы</kwd><kwd>слизистая оболочка полости рта</kwd><kwd>состав слюны</kwd><kwd>гнатодинамометрия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Alimov AS, Gaffarov SA, Alimov AA. Optimization of orthopedic dental therapy in HIV-infected patients taking into account the state of the periodontium. In: Proceedings of the International Scientific and Practical Conference “Medical Science in the Era of Digital Transformation”; 2021 Oct 12; Kursk. (In Russ.) Available from: https://ksmuconfs.org/wp-content/uploads/2021/12/sbornic-conf-10_12_21.pdf</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Astanov OM, Gafforov SA. Improvement of diagnostics of ogre syndromes in the temporomandibular joint activity, formed at complications of dental caries and defects of the masticatory surface. Ministry of Health of the Republic of Uzbekistan; 2021. Protocol No. 968. (In Uzbek).</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Bazikyan EA, Belyakova S, Pchelin IV. Justification of research on system optimization of surgical dental care to patients with HIV infection. Žurnal infektologii. 2018;10(3):45–53. doi: 10.22625/2072-6732-2018-10-3-45-53</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Gafforov SA, Pulatova RS. Clinical and functional assessment of the state of hard tissues of teeth and oral mucosa of HIV-infected patient. Medical Journal of Uzbekistan. 2023;(3):20–31. (In Russ.) Available from: https://journals.tnmu.uz/index.php/uzmedjournal/issue/view/15/29</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Gafforov SA, Pulatova RS. Comparative assessment of the state of tissues and organs of the oral cavity of HIV-infected patients. Integrative Dentistry and Maxillofacial Surgery. 2023;2(2):65–73. doi: 10.57231/j.idmfs.2023.2.2.009</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Djumaev ZF, Kayumov GO, Gafforov SA, et al. Restoration of defects of the maxillofacial region after oncological surgeries. Journal of oral medicine and craniofacial research. 2024;5(1):23-29 (In Russ.) Available from: https://www.tadqiqot.uz/index.php/oral/article/view/9728/9283</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Nazarov YK, Gafforov SA. Significance of using modern methods of examination in predicting defects of temporomandibular joint and dental arch formation in connective tissue dysplasia. Ministry of Health of the Republic of Uzbekistan; 2023. Protocol No. 8n-r/88. (In Uzbek).</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Gafforov SA, Nazarov UK, Xen DN, Fazilbekova GA. General and local stomatological and immunogenetic changes with undifferentiated connective tissue dysplasia. Russian Journal of Dentistry. 2022;26(1):5–14. doi: 10.17816/1728-2802-2022-26-1-5-14 EDN: VPMOUY</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>da Silva Barboza A, Aitken-Saavedra JP, Ferreira ML, et al. Are propolis extracts potential pharmacological agents in human oral health? — A scoping review and technology prospecting. J Ethnopharmacol. 2021;271:113846. doi: 10.1016/j.jep.2021.113846</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Gafforov SA, Pulatova RS. Comparative estimates of the morphological structure of the surface of removable dentures made of different materials for the replacement of dentition defects. Science and Innovation. 2023;2(12):918–924. doi: 10.5281/zenodo.10405778</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Gafforov SA, Pulatova RS. Clinical and laboratory studies of basic materials “Fluorax” and “Vertex TermoSens” used in dental prosthetics of HIV-infected patients. In: Proceedings of the International University Scientific Forum “Practice Oriented Science: UAE–RUSSIA–INDIA”. Ufa: Infiniti; 2023. P. 131–140. doi: 10.34660/INF.2023.80.56.059 EDN: JYEHWB</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Ubaydullayev KA, Gafur-Akhunov MA, Gafforov SA. Method of rehabilitation treatment and orthopedic prosthetics of oncologial patients with postoperative defects in maxillofacial area. American Journal of Medicine and Medical Sciences. 2021;11(2):95–98. doi: 10.5923/j.ajmms.20211102.05</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Glick M, Williams DM. FDI Vision 2030: delivering optimal oral health for all. Int Dent J. 2021;71(1):3–4. doi: 10.1016/j.identj.2020.12.026 EDN: WXEWEW</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Jain P, Keating M, Wierda W, et al. Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib. Blood. 2015;125(13):2062–2067. doi: 10.1182/blood-2014-09-603670</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Pulatova RS, Mustafaeva DA. Methods of testing the condition of the oral cavity in patients with HIV infection. Research Journal of Trauma and Disability Studies. 2024;3(1):83–86.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Nikou SA, Kichik N, Brown R, et al. Candida albicans interactions with mucosal surfaces during health and disease. Pathogens. 2019;8(2):53. doi: 10.3390/pathogens8020053 EDN: QVGRNW</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Pulatova RS, Gafforov SA, Nurmatova NT. Clinical evaluation of the effectiveness of thermoplastic materials used in the dental prosthetics of HIV-infected patients. Journal of Chemical Health Risks. 2023;13(4):484–495.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Keser G, Yılmaz G, Pekiner FN. Assessment of knowledge level and awareness about human papillomavirus among dental students. J Cancer Educ. 2021;36(4):664–669. doi: 10.1007/s13187-019-01683-3 EDN: VZTIVM</mixed-citation></ref></ref-list></back></article>
