No 6 (2008)

The leading role of pyogenic bacteria vs. human periodontopathogenic microflora was demonstrated on an experimental model of periodontitis in rats. The application of resident microflora belonging to the anaeroblc-mlcroaerophilic group (a mixture of reference strains of Veillonella parvula+ Streptococcus salivarius; the density of the suspension of the both bacterial strains for colonization was l(f CFU/ml in the nutrient medium AC (Oxoid)) with drinking water positively influenced oral mucosa microbiocenosis in rats, which manifested by complete elimination of staphylococci and reduction of total microbial insemination. The pathomorphological study demonstrated that restorative processes in periodontal tissues ran substantially faster in rats receiving resident microflora.

The application of heponum in complex therapy of patients with chronic generalized periodontitis normalizes cytokine profile balance, i.e. reduces the concentration of pro-inflammatory cytokines (IL-1/3, TNF-a, and IF-y) in the periodontal pocket contents, increases the concentration of the pro-inflammatory 1L-4, and normalizes the contents of IgG and slgA. Local application of heponum makes it possible to increase the quality of treatment, reduce preoperative preparation time to 10 days (vs. 14 to 16 days when conventional treatment is applied), shorten postoperative rehabilitation, and achieve stable remission in 82% of patients with mild chronic periodontitis and 77% of patients with moderate periodontitis after 6 months of observation.

Changes in pro- and antioxidaiive status variables in 13 patients with odontogenic maxillofacial phlegmons were analyzed; some of the variables were found to be altered to some degree. Sodium hypochlorite, rexode, and reamberine were shown to be efficient in correction of the disturbances of the pro- and antioxidaiive status vs. the basic therapy in this group of patients.