An experimental study of the influence of samples of acrylic plastic dental prostheses on manifestations of short-term IgE-dependent bronchial asthma

The authors conducted an experimental study of the influence of samples of dental prostheses of Etacryl, an acrylic plastic manufactured by polymerization on a water bath (E-WB) or by MW polymerization (E-MW), on manifestations of short-term IgE-dependent bronchial asthma (EBA). Mice with EBA, to which E-WB or E-MW samples were implanted, were afterwards studied macro- and microscopically. It was found that E-MW implantation caused less prominent local inflammation than E-WB implantation. Bronchopulmonary lavage (BPL) cell composition did not change substantially, and eosinophils constituted the majority of infiltrated tissue cells, whose significant increase in number evidenced the development of experimental bronchial asthma in these mice; at the same time, there was no pronounced inflammation, which was evidenced by insignificant increase BPL lymphocytes in all the groups of sensitized animals.
The levels of anti-OA (ovalbumin) serum IgE antibodies increased after intraperitoneal OA injection and increased abruptly after intranasal application, but this increase had no correlation with acrylic plastic implantation, with, conversely, had an immunodepressive effect.

dental prostheses, acrylic plastic, IgE-dependent bronchial asthma model, bronchopulmonary lavage, antibodies