N-Acyl Derivatives of 2-Amino-4,6-di-tERt-butylphenol — Potential Protectors Under Neutrophil-Induced Halogenating Stress

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The effect of N-acyl derivatives of 2-amino-4,6-di-tert-butylphenolon the functions of neutrophils was studied. It has been established that these derivatives with a free hydroxyl group in the benzene ring, in contrast to O-methylated ones, modify the properties of cells, which is expressed in a decrease in hypochlorous acid generation during the “respiratory burst” formation. These compounds are scavengers of HOCl/OCl– generated by activated neutrophils and reduce the secretion of myeloperoxidase (MPO) from cells. N-(3,5-di-tert-butyl-2-hydroxyphenyl)acetamide has been shown to be the most effective hypochlorous acid scavenger. This substance significantly suppresses the secretory degranulation of neutrophils and has a cytoprotective effect under conditions of halogenating stress.

作者简介

G. Semenkova

Belarusian State Medical University

编辑信件的主要联系方式.
Email: n.amaegberi@gmail.com

Research Laboratory

白俄罗斯, Minsk, 220083

I. Zholnerevich

Belarusian State University

Email: n.amaegberi@gmail.com
白俄罗斯, Minsk, 220030

E. Kovalenko

Belarusian State University

Email: n.amaegberi@gmail.com
白俄罗斯, Minsk, 220030

G. Ksendzova

Belarusian State University

Email: n.amaegberi@gmail.com

Research Institute for Physical Chemical Problems

白俄罗斯, Minsk, 220030

V. Sorokin

Belarusian State University

Email: n.amaegberi@gmail.com
白俄罗斯, Minsk, 220030

N. Amaegberi

Belarusian State University

Email: n.amaegberi@gmail.com
白俄罗斯, Minsk, 220030

A. Klimovich

Belarusian State University

Email: n.amaegberi@gmail.com
白俄罗斯, Minsk, 220030

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