Highly selective nonsteroidal anti-inflammatory drugs in the prevention of postoperative pain symptoms

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BACKGROUND: Patients often visit healthcare institutions for the treatment of various diseases, which are accompanied by painful symptoms. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used for the prevention and relief of pain symptoms in surgical and trauma departments, providing good clinical results and analgesic effects.

AIM: This study aimed to evaluate the effectiveness of etoricoxib at various dosages for the prevention of pain symptoms after complex removal of the lower wisdom teeth.

MATERIAL AND METHODS: The patients were 108 (67 men and 41 women) young people (18–32 years old) who underwent a complex removal of an impacted and/or dystopic lower wisdom tooth for orthodontic indications. During the clinical study, the patients were divided into five groups depending on the use and dosage of the highly selective NSAID etoricoxib.

RESULTS: In the clinical study, etoricoxib was used at dosages of 30, 60, 90, and 120 mg to prevent pain in 108 patients aged 18–32 years who underwent complex removal of the lower wisdom teeth according to orthodontic parameters. For these purposes, it is effective and sufficient to use the drug at a dosage of 60 mg. Etoricoxib also prevented the occurrence of infectious and inflammatory postoperative complications, such as alveolitis, and provided better patient tolerance to the surgical intervention.

CONCLUSION: This clinical study on the effectiveness of etoricoxib at various dosages for the prevention of pain symptoms after removal the lower wisdom tooth showed the effectiveness of 60 mg, which should be taken 60–90 min before surgery and in the next 2–3 days in the morning. Etoricoxib not only provided a significant reduction in pain intensity in the postoperative period but also prevented the occurrence of infectious and inflammatory postoperative complications and enabled better patient tolerance to the surgical intervention. Etoricoxib dosages of 90 mg and 120 mg are not advisable for the prevention of pain symptoms in surgical dentistry. Such dosages are necessary for complex treatment of dental diseases, accompanied by a chronic pain syndrome.

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About the authors

Andrey K. Iordanishvili

International Academy of Sciences of Ecology, Human Security and Nature; Military Medical Academy named after S.M. Kirov

Email: professoraki@mail.ru
ORCID iD: 0000-0003-0052-3277

MD, Dr. Sci. (Med.), professor

Russian Federation, St. Petersburg; St. Petersburg

Mikhail M. Shvetsov

Dental Polyclinic № 29

Author for correspondence.
Email: mishas14@me.com
ORCID iD: 0000-0003-3230-0334
Russian Federation, St. Petersburg


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Supplementary files

Supplementary Files
1. Fig. 1. Distribution of patients by gender in the study groups (abs)

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2. Fig. 2. Average indicators of pain symptom intensity in patients of the studied groups according to the values of the Visual Analog Pain scale, points

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Свидетельство о регистрации СМИ № 015648 от 14.05.1999 г. выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор). 
Свидетельство о регистрации СМИЭЛ № ФС 77 - 80635 от 15.03.2021 г. выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).

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