Email this article 
Highly selective nonsteroidal anti-inflammatory drugs in the prevention of postoperative pain symptoms
- Authors: Iordanishvili A.K.1,2, Shvetsov M.M.3
-
Affiliations:
- International Academy of Sciences of Ecology, Human Security and Nature
- Military Medical Academy named after S.M. Kirov
- Dental Polyclinic № 29
- Issue: Vol 25, No 6 (2021)
- Pages: 517-522
- Section: Clinical Investigation
- URL: https://rjdentistry.com/1728-2802/article/view/108486
- DOI: https://doi.org/10.17816/1728-2802-2021-25-6-517-522
- ID: 108486
Cite item
Open Access
Access granted
Abstract
BACKGROUND: Patients often visit healthcare institutions for the treatment of various diseases, which are accompanied by painful symptoms. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used for the prevention and relief of pain symptoms in surgical and trauma departments, providing good clinical results and analgesic effects.
AIM: This study aimed to evaluate the effectiveness of etoricoxib at various dosages for the prevention of pain symptoms after complex removal of the lower wisdom teeth.
MATERIAL AND METHODS: The patients were 108 (67 men and 41 women) young people (18–32 years old) who underwent a complex removal of an impacted and/or dystopic lower wisdom tooth for orthodontic indications. During the clinical study, the patients were divided into five groups depending on the use and dosage of the highly selective NSAID etoricoxib.
RESULTS: In the clinical study, etoricoxib was used at dosages of 30, 60, 90, and 120 mg to prevent pain in 108 patients aged 18–32 years who underwent complex removal of the lower wisdom teeth according to orthodontic parameters. For these purposes, it is effective and sufficient to use the drug at a dosage of 60 mg. Etoricoxib also prevented the occurrence of infectious and inflammatory postoperative complications, such as alveolitis, and provided better patient tolerance to the surgical intervention.
CONCLUSION: This clinical study on the effectiveness of etoricoxib at various dosages for the prevention of pain symptoms after removal the lower wisdom tooth showed the effectiveness of 60 mg, which should be taken 60–90 min before surgery and in the next 2–3 days in the morning. Etoricoxib not only provided a significant reduction in pain intensity in the postoperative period but also prevented the occurrence of infectious and inflammatory postoperative complications and enabled better patient tolerance to the surgical intervention. Etoricoxib dosages of 90 mg and 120 mg are not advisable for the prevention of pain symptoms in surgical dentistry. Such dosages are necessary for complex treatment of dental diseases, accompanied by a chronic pain syndrome.
Full Text
About the authors
Andrey K. Iordanishvili
International Academy of Sciences of Ecology, Human Security and Nature; Military Medical Academy named after S.M. Kirov
Email: professoraki@mail.ru
ORCID iD: 0000-0003-0052-3277
MD, Dr. Sci. (Med.), professor
Russian Federation, St. Petersburg; St. PetersburgMikhail M. Shvetsov
Dental Polyclinic № 29
Author for correspondence.
Email: mishas14@me.com
ORCID iD: 0000-0003-3230-0334
Russian Federation, St. Petersburg
References
- Gaivoronskii IV, Iordanishvili AK, Vasil’chenko GA, et al. Retentsiya zubov mudrosti nizhnei chelyusti. Saint Petersburg: Nordmedizdat; 2011. 142 p. (In Russ).
- Iordanishvili AK. Sovety vrachu-stomatologu po vypolneniyu in”ektsionnykh metodov obezbolivaniya na chelyustyakh. The Dental Institute. 2005;(2):64–65. (In Russ).
- Patent RUS № 78669/ 10.12.2008. Byul. № 34. Gaivoronskii IV, Iordanishvili AK, Vasil’chenko GA. Elevator dlya udaleniya tret’ikh molyarov: patent na poleznuyu model’. Available from: https://rusneb.ru/catalog/000224_000128_0000078660_20081210_U1_RU/
- Iordanishvili AK. Khirurgicheskoe lechenie periodontitov i kist chelyustei. Saint Petersburg: Nordmedizdat; 2000. 217 p. (In Russ).
- Iordanishvili AK, Vasil’chenko GA, Sagalatyi AM, Il’ina OY. Medical, social and economic aspect of difficult eruption of the third molars abstract. The Dental Institute. 2011;(1):28–29. (In Russ).
- Iordanishvili AK. Gerontostomatologiya. Saint Petersburg: Chelovek; 2015. 240 p. (In Russ).
- Iordanishvili AK. Vozrastnye izmeneniya zhevatel’no-rechevogo apparata. Saint Petersburg: Chelovek, 2015. 140 p. (In Russ).
- Iordanishvili AK, Soldatkina AS. Diseases of mouth organs and tissues in young person. The Dental Institute. 2015;(3):38–40. (In Russ).
- Iordanishvili AK, Veretenko EA, Mironenko AN. Meditsinskie, sotsial’nye, ekonomicheskie i yuridicheskie aspekty stomatologicheskogo lecheniya lyudei starshikh vozrastnykh grupp. Ekolo- giya i razvitie obshchestva. 2015;(3):63–65.
- Muzykin MI, Iordanishvili AK, Ryzhak GA. Periostity chelyustei i ikh lechenie. Saint Petersburg: Chelovek; 2015. 112 p.
- Moore A, Edwards J, Barden J, McQuay H. Bandolier’s Little Book of Pain. Oxford: Oxford Universiti Press; 2003. 279 p.
- Malmstrom K, Sapre A, Couglin H, et al. Etoricoxib in acute pain associated with dental surgery: a randomized, double-blind, placebo- and active comparator-controlled dose-ranging study. Clin Ther. 2004;26(5):667–679. doi: 10.1016/s0149-2918(04)90067-7
- Caruso S, Storti E, Nota A, et al. Temporomandibular Joint Ana- tomy Assessed by CBCT Images. Biomed Res Int. 2017;2017:2916953. doi: 10.1155/2017/2916953
- Cillo JE, Jr, Ellis E, 3rd. Treatment of patients with double unilateral fractures of the mandible. J Oral Maxillofac Surg. 2007;65(8):1461–1469. doi: 10.1016/j.joms.2006.08.013
- Kozakiewicz M, Swiniarski J. “A” shape plate for open rigid internal fixation of mandible condyle neck fracture. J Craniomaxillofac Surg. 2014;42(6):730–737. doi: 10.1016/j.jcms.2013.11.003
- Romeo A, Pinto A, Cappabianca S, et al. Role of multidetector row computed tomography in the management of mandible traumatic lesions. Semin Ultrasound CT MR. 2009;30(3):174–180. doi: 10.1053/j.sult.2009.02.008
- Schumacher GH. Anatomie für stomatologen Lehrbuch und Atlas. Leipzig: Johann Ambrosius Barth; 1984. 300 p. (In Germ).
Supplementary files
