Effectiveness of nicotinamide adenine nucleotide hydride in the complex treatment of patients with peri implantitis

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Abstract

Background: In treating peri-implantitis, dentists pay attention to drugs that do not contain chemically aggressive agents. They rather use those having natural mechanisms for normalization of the functional activity of cells and tissues in addition to local antiseptic and antibacterial agents.

The aim of the study was to determine the clinical effectiveness of nicotinamide adenine nucleotide hydride dental gel in the treatment of peri-implantitis.

Materials and methods: Depending on the therapeutic tactics patients (n = 40), we divided patients into two groups. In Group 1 (n = 20), we used a standard treatment of peri-implantitis including professional hygiene measures, antiseptic treatment and the use of antibacterial agents. In Group 2 (n = 20), the complex treatment included photodynamic effects of 1% photosensitizer gel instead of the antibacterial therapy.

Results: Due to the use of the photodynamic therapy in addition to standard treatment of group 2 patients, the concentration of a tartrate-resistant acid phosphatase in the peri-implantation exudate reached the level of healthy people in the gingival fluid. In addition, the concentrations of cathepsin K and interleukin-6 were as close as possible to the control level.

Conclusion: The use of NADH for peri-implantitis helps to eliminate inflammatory phenomena and stimulates the regeneration of the oral mucosa.

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About the authors

M. A. Amkhadova

Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Email: elchin@aleskerov.ru
Russian Federation, Moscow

I. S. Amkhadov

Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Email: elchin@aleskerov.ru
Russian Federation, Moscow

El’chin Sh. Sh.-O. Aleskerov

Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Author for correspondence.
Email: elchin@aleskerov.ru

postgraduate student in Chair of Oral Surgery and Implantology, Faculty of Advanced Medical Education in Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Russian Federation, Moscow

V. I. Zelensky

Stavropol State Medical University

Email: elchin@aleskerov.ru
Russian Federation, Stavropol

E. A. Remizova

Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Email: elchin@aleskerov.ru
Russian Federation, Moscow

A. A. Atamanchuk

Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Email: elchin@aleskerov.ru
Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Study design.

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3. Fig. 2. Median, interquartile range and age range of patients in groups 1 and 2.

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4. Fig.3. The frequency of exceeding the clinically significant concentration of bacteria in the contents of the peri-implantation pocket in the groups before treatment.

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