COMPARATIVE ANALYSIS OF COMPREHENSIVE RESEARCH DATA ON THE ORAL MICROFLORA IN PATIENTS WITH PERIODONTITIS OF VARYING SEVERITY



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Abstract

BACKGROUND: The oral cavity (OC) is known to be a favorable environment for the reproduction and biological activity of most microorganisms. At the same time, both positive symbiotic interactions and negative effects on the soft tissues of the periodontal complex, including representatives of the normal microflora, are observed.

AIMS: To determine the etiopathogenetic role of the main inhabitants of the oral cavity (OC) and their frequency among patients with periodontitis and a control group (CG) of healthy individuals. The primary criteria for patient examination included the presence of hyperemia, edema in the mucosa, and other visible pathologies of the periodontal complex with signs of exacerbation.

MATERIALS AND METHODS: The authors of the article conducted a comparative analysis of the frequency of various bacterial pathogens in the oral cavity (OC) among patients with periodontitis of varying severity and a control group (CG) of healthy individuals, as well as their role in the etiology of periodontal complex diseases.

RESULTS: The results of the study showed that an analysis of the composition of the mucosal microflora of the oral cavity (OC) and gums, using both classical and modern methods, revealed significantly more frequent changes in the periodontal complex microflora among individuals with various inflammatory periodontal diseases. These changes included an increase in the number of both periodontopathogenic agents and pathogenic coccal flora.

CONCLUSIONS: The combination of microorganisms from the "red complex" together with Streptococcus pyogenes and Staphylococcus aureus promotes the formation of biofilms and a higher risk of exopolymeric matrix destruction, which corresponded to the clinical manifestations and severity of periodontitis progression.

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About the authors

Nodira To’xtaxodjaevna Nurmatova

Ministry of Health of the Republic of Uzbekistan, Center for Professional Development of Medical Workers

Email: nurmatovanodira@gmail.com
ORCID iD: 0009-0000-5853-4062
Uzbekistan, Tashkent, Uzbekistan, Mirzo Ulugbek District, Parkent Street, Building 51, IN: 100007

Sunnatullo Amrulloevich Gafforov

Центр развития профессиональной квалификации медицинских работников (бывш. ТашИУВ)

Email: sunnatullogafforov@mail.ru

Доктор медицинских наук, профессор. Зав. кафедрой Стоматологии, детской стоматологии и ортодонтии, ЦРПКМР

Uzbekistan

Nargiza Abitovna Shadmanova

Center for Retraining and Advanced Training of Personnel in the Field of Sanitary-Epidemiological Welfare and Public Health

Author for correspondence.
Email: shadmanova06@yahoo.com
ORCID iD: 0009-0005-2610-4021
Tashkent, Uzbekistan, Chilanzar District, Bunyodkor Street, Building 46, IN: 100097

Javoxirmirzo Dilmurodjonovich Odiljonov

Ministry of Health of the Republic of Uzbekistan, Center for Professional Development of Medical Workers

Email: black_prince1112@mail.ru
ORCID iD: 0009-0005-4575-2884
Uzbekistan, Tashkent, Uzbekistan, Mirzo Ulugbek District, Parkent Street, Building 51, IN: 100007

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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