Analysis of reparative osteogenesis in the augmentation zone using allogeneic lyophilized spongy bone tissue



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Abstract

BACKGROUND: The use of the implantation method in dental practice is constantly growing. The indications for its implementation are expanding, including in cases of significant atrophy of the alveolar process in order to restore bone volume using osteoplastic materials. The study of metabolic processes remains a pressing issue.

AIM: To evaluate reparative osteogenesis in the augmentation zone with allogeneic lyophilized cancellous bone tissue by analyzing metabolic criteria.

MATERIALS AND METHODS: The study included 41 people in the main group and 17 in the control group at the stage of osseointegration with an observation period of 1 to 12 weeks, the object of the study was oral fluid. Allogeneic lyophilized spongy bone tissue was used in the augmentation zone.

RESULTS: At 1–2 weeks, no statistically significant differences from the control values ​​were found. However, at 3–4 weeks, a slight increase in collagen C-telopeptide, osteocalcin, and a decrease in the activity of alkaline phosphatase and parathyroid hormone were noted. These changes indicate the development of the secondary remodeling stage by forming an osteoid matrix. After 12 weeks of observation, metabolic parameters are restored, indicating reparative osteogenesis.

CONCLUSION: The use of lyophilized spongy bone tissue ensures physiological osteogenesis.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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