Observation of migration and survival of mesenchymal stem cells in a model of critical bone defect in dental implantation areas: An experimental laboratory study in vivo

BACKGROUND:. The ability of MSCs to migrate from the site of local administration to adjacent areas of injury and participate in tissue repair may expand the clinical applications of stem cells in regenerative medicine and improve treatment outcomes for patients suffering from various injuries and diseases.

AIM: Study of the migration behavior of MSCs from the area of ​​local administration to the area of ​​damage and participation in tissue restoration during dental implantation.

METHODS: In our work, rat adipose tissue mesenchymal stem cells (MSCs) were labeled with a vital fluorescent dye and transplanted into the area of critical bone defect in the rat parietal bone.… .

RESULTS: Live dynamic imaging of MSCs in the rat body was carried out, and the preservation of cells in the area of bone damage and their ability to migrate to the lesion focus from remote injection sites during the 14-day observation period were demonstrated.

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CONCLUSION: Our study provides important information about the migratory behavior of MSCs and their potential for tissue regeneration in the context of bone defects. The ability of MSCs to migrate from the area of local injection to adjacent areas of injury and participate in tissue repair can expand the potential of clinical application of stem cells in regenerative medicine and improve treatment outcomes for patients suffering from various injuries and diseases… .