Email this article 
ANALYSIS OF THE PREVALENCE OF ORAL MUCOSA DISEASES IN XEROSTOMIA AGAINST THE BACKGROUND OF GENERAL SOMATIC DISEASES. LITERATURE REVIEW
- Authors: Muziukin I.S.1, Lapina N.V.1, Ovcharenko E.S.1, Shtatsky A.I.1, Lapin V.V.1
-
Affiliations:
- Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Health of the Russian Federation
- Section: Reviews
- Submitted: 29.04.2025
- Accepted: 21.05.2025
- Published: 22.07.2025
- URL: https://rjdentistry.com/1728-2802/article/view/678991
- DOI: https://doi.org/10.17816/dent678991
- ID: 678991
Cite item
Open Access
Access granted
Abstract
Xerostomia, or dry mouth, is becoming an increasingly common problem among patients visiting a dentist, accouting for approximately 40%. Dry mouth makes it difficult to chew food normally, reduces the perception of tastes, and causes constant anxiety about the condition of the teeth. It is important to note that this affects not only the physical health, but also the psychoemotional state of patients. Based on a literature search in the PubMed, Scopus and Web of Science, Google Scholar, eLIBRARY databases, it was determined that in original peer-reviewed studies, from 30% to 50% of cases of xerostomia are detected against the background of various pathological conditions of the periodontal tissues and oral mucosa: gingivitis, periodontitis, potentially malignant, allergic, autoimmune, infectious and neurogenic diseases of the oral mucosa, which often develop not only as independent diseases, but also as concomitant pathologies in patients with various general somatic diseases, including neurogenic and psychodepressive genesis. It was established that at present there is no protocol for the diagnosis and treatment of patients with xerostomia against the background of psychodepressive disorders. It is also necessary to study in detail the state of the pro- and antioxidant system of oral fluid and correct its state in this category of patients, since these problems significantly affect the quality of life of patients, affecting their social interactions and daily activities, therefore, a more detailed study of this issue is required.
Full Text
About the authors
Iurii Sergeevich Muziukin
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: yumuz2017@gmail.com
ORCID iD: 0009-0009-0944-8841
Assistant Professor of the Department of Dentistry, Postgraduate Student
Russian Federation, 350063, Russian Federation, Krasnodar region, Krasnodar, st. named after Mitrofan Sedin, 4 (Central microdistrict)Natalya Viktorovna Lapina
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Health of the Russian Federation
Email: Kgma74@yandex.ru
ORCID iD: 0000-0003-1835-8898
SPIN-code: 8060-4683
Scopus Author ID: 57140233900
ResearcherId: R-6569-2017
Head of the Department of Orthopedic Dentistry, Head of the Department of Dentistry, Doctor of Medical Sciences, Professor, Dentist-Orthopedist of the Highest Category
Russian Federation, 350063, Russian Federation, Krasnodar region, Krasnodar, st. named after Mitrofan Sedin, 4 (Central microdistrict)Evgeniya Sergeevna Ovcharenko
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Health of the Russian Federation
Email: ovcharenkoes@mail.ru
ORCID iD: 0000-0002-0132-2517
SPIN-code: 6874-5734
Associate Professor of the Department of Dentistry, PhD, Associate Professor, Dentist of the highest category
Russian Federation, 350063, Russian Federation, Krasnodar region, Krasnodar, st. named after Mitrofan Sedin, 4 (Central microdistrict)Aleksandr Ivanovich Shtatsky
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Health of the Russian Federation
Email: shtatskyyy@mail.ru
ORCID iD: 0009-0006-8479-6131
5th year student of the Faculty of Dentistry
Russian Federation, 350063, Russian Federation, Krasnodar region, Krasnodar, st. named after Mitrofan Sedin, 4 (Central microdistrict)Vadim Vadimovich Lapin
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Health of the Russian Federation
Email: lapinvadim777@gmail.com
ORCID iD: 0009-0003-5768-6218
SPIN-code: 1763-2453
4th year student of the Faculty of Dentistry
Russian Federation, 350063, Russian Federation, Krasnodar region, Krasnodar, st. named after Mitrofan Sedin, 4 (Central microdistrict)References
- Pina G.M.S. et al. Prevalence of hyposalivation in older people: A systematic review and meta-analysis // Gerodontology. 2020. Vol.34. N 4. P. 317-331. PMID: 32965067.
- Hou l., Cui Y., Ye L. at al., Metabolomic signals into idiopathic xerostomia: The central role of caffeine metabolism in salivary biochemistry // Oral Biology. Vol. 169. p. 102-106. doi: 10.1016/j.archoralbio.2024.106102.
- Belenova I.A., Kopbaeva M.T., Popova O.B., Smazhko O.A. 2023. Xerostomia as an idiopathic symptom in dentistry. Applied information aspects of medicine, 26(1): 36–41.(In Russ) doi: 10.18499/2070-9277-2023-26-1-36-41.
- Kochurova E.V., Kudasova E.O., Nikolenko V.N., Panferova O.I. The role of oral fluid biomarkers in the diagnosis of oral mucosa cancer // Issues of oncology. 2022. (In Russ) doi: 10.37469/0507-3758-2022-68-5-565-570
- Makedonova Yu.A., Poroisky S.V., Gavrikova L.M., Afanasyeva O.Yu. Oral manifestations in patients after COVID-19 // 2021. (In Russ) doi: 10.19163/1994-9480-2021-1(77)-110-115
- Skvortsova E.N., Mitina O.N., Zyulkina L.A., Efremova A.V., Osipova A.V. Evaluation of the effectiveness of an individual prevention program in the treatment of periodontitis in elderly patients // 2024. (In Russ) doi: 10.21685/2072-3032-2024-1-2
- Trukhatkina S.A., Zhdanova E.S. Caries of permanent teeth: etiology, treatment and prevention. 2025 // International scientific journal "BULLETIN OF SCIENCE" No. 1 (82) Volume 3. JANUARY 2025 p. 1339-1343 (In Russ) ISSN 2712-8849
- Khan, S., Ali, S., Ahmad, M.Z., Rehman, I.U., Khan, A.A. (2020). Prevalence of xerostomia and its correlation with oral health status in type 2 diabetic patients. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 14(1), 121-125. doi: 10.17219/dmp/147754
- Shi X, Zong D, Lu Z, Li S, Kong F. Effects of childcare disagreement with children, social support, and health status on unmet healthcare-seeking behavior among the older migrants with children to Jinan, China. Front Public Health 2022; 10: 957619, doi: 10.3389/fpubh.2022.957
- Mei He, Wuda Huoshen, Xueqing Li, Chen Sun (2024). Salivary and serum biomarkers to evaluate psychological disorders in burning mouth syndrome: A systematic review and meta-analysis. J Oral Pathol Med 2024 182-192 PMID: 38438274
- M. Molek, F. Florenly, I. N. E. Lister, T. A. Wahab, C. Lister4, F. Fioni, (2022). Xerostomia and hyposalivation in association with oral candidiasis: a systematic review and meta-analysis, 1-7. doi: 10.1038/s41432-021-0210-2
- Vecherkina Zh.V., Chirkova N.V., Smolina A.A., Kalinichenko N.V., Donov A.N. Analysis of compliance behavior and its relationship with dental morbidity of dysbiotic and inflammatory nature of the oral mucosa in patients with removable dentures // Systems analysis and management in biomedical systems. 2023. No. 2. P. 59-64. // (In Russ) doi: 10.24411/1609-2163-2020-16684
- Pina, G., Mota Carvalho, R., Silva, B., & Almeida, F. T. (2020). Prevalence of hyposalivation in older people: A systematic review and meta-analysis. Gerodontology, 37, 317–331. doi: 10.1111/ger.12497
- Cortés-Rojas, B., Aguilar-Salvatierra, A., Rodríguez-Lozano, B., Castillo-Oyagüe, R. (2022). Xerostomia and its impact on oral health-related quality of life: a systematic review. International Journal of Environmental Research and Public Health, 19(13), 7882. doi: 10.1007/s00391-015-0968-y
- Suryana K, Suharsono H, Antara I G P J. Factors associated with oral candidiasis in people living with HIV/AIDS: a case control study. HIV AIDS (Auckl) 2020; 12:33-39. PMID: 32021484
- Metelitsa K.I., Manak T.N. Xerostomia and its complications in the oral cavity // Modern dentistry. 2021. No. 2. P. 6-10. (In Russ) eLIBRARY ID: 46500743
- Afanasyev V.V., Vinokurov N.S., Sirota N.A. Features of the treatment of patients with true xerostomia using the correction of their psychoemotional status // Cafedra-Department. Dental education. 2022. No. 79. P. 62-64. (In Russ) eLIBRARY ID: 48382319
- Basharova O.V., Kabirova M.F., Kuznetsova N.S. Prevalence of xerostomia among patients in a state of psychoemotional stress. In the collection: Actual issues of dentistry. Collection of scientific papers of the XI Volga Region Dental Forum. Ufa, 2021. Pp. 379-384. (In Russ) eLIBRARY ID: 48116125
- Chirkova K.E., Leshcheva E.A., Kuchumova E.D., Chirkova N.V., Vecherkina Zh.V., Podoprigora D.V. The influence of stress resistance on dry mouth syndrome // International medical scientific journal No. 4 (58), 2024 51-54 // (In Russ) ISSN 2409-563X. MEDICUS. 2024 No. 4 (58).
- Karimi M., Hajicolaei F.A., Haseinpour F., Hashemi S.A., Fatehi A., Pakmehr S.A., Deravi N., Naziri M., Beldasi M., Khoshravesh S., Vezzadex S.H. Efficacy of Cevimeline on Xerostomia in Sjogren, s syndrome patients: a systematic review and meta-analysis of randomized clinical trials // Current therapeutic research. 2025. Vol. 102. P. 1-6. USA 016/j.curtheres.2024.100770. PMID: 39867639
- Konovalova T.A., Kozlova M.V., Chorbinskaya S.A., Manuilov B.M., Aleshkin V.A. Features of the treatment of sialadenosis of the parotid salivary glands in patients undergoing eradication treatment // Periodontology. 2024. No. 2. P. 175-183. (In Russ) doi: 10.33925/1683-3759-2024-944
- Porangaba L.P., et al. Randomized Double–Blind Placebo-Controlled Study of Salivary substitute with Enzymatic system for Xerostomia in patients irradiated in head and neck region // Current oncology. 2024. Vol. 31. P. 1102-1112. PMID: 38392076.
- Chirkova K.E., Leshcheva E.A., Andreeva E.A., Morozov A.N., Vecherkina Zh.V., Khelminskaya N.V. Risk of dental diseases in patients with drug-induced xerostomia // Systems analysis and control in biomedical systems. 2024. No. 1. P. 78-86. (In Russ) eLIBRARY ID: 65621231
- Shishkina O.E., Vorobyova V.M., Mazko O.N., Semennikova N.V., Berent E.A., Loor K.S. Comparative characteristics of compositions for symptomatic therapy of xerostomia // Clinical dentistry. 2024. No. 4. P. 40 – 53. (In Russ) doi: 10.37988/1811-153Х_2024_4_40.
- Wagner V.D., Korshunov A.S., Konev V.P., Kuryatnikov K.N., Skuikhina A.P., Bondar A.P. Complete removable plate denture for the upper jaw with a reservoir for artificial saliva. – Patent. – RU 211184, valid. 05.24.2022. (In Russ)
- Grigoriev S.S., Kudinov P.N., Burlak A.V. Dry mouth syndrome (literature review) // Ural Medical Journal. 2019. No. 12. P. 18-25. (In Russ) doi: 10.25694/URMJ. 2019.12.07
- Izrailov AM, Antonova IN Efficiency of local use of hyaluronic acid preparations in patients with xerostomia of various etiologies // Institute of Dentistry. 2023. No. 3. P. 74-76. (In Russ) eLIBRARY ID: 54503741
- Shirokova AV, Turkina AY, Paramonova YuO. Prospects for the use of synthetic lactoferrin for the prevention and treatment of dental diseases // Russian Dental Journal. 2019. No. 23. P. 84-90. (In Russ) doi: 10.18821/1728-2802-2019-23-2-84-90.
- Kapourani A., et al. A review on xerostomia and its various management strategies: The role of advanced polymeric materials in the treatment of aprproaches // Polymers (Basel). 2022. Vol.14. p. 850. PMID: 35267672.
- Volosova E.V., Panin A.M., Tsitsiashvili A.M., Shishkanov A.V., Nilva A.I. Problems of diagnostics and treatment of patients with xerostomia. A modern view // Medical alphabet. 2020. No. 35. P. 44-47. (In Russ) doi: 10.33667/2078-5631-2020-35-44-47.
- Nekrasov A.N., Tiunova N.V., Zhdanova M.L. Flaming mouth syndrome: assessment of xerostomia symptom manifestations, pH and buffer capacity of the oral cavity // Operative surgery and clinical anatomy. 2023. No. 4. P. 57-60. (In Russ) doi: 10.17116/operhirurg2023704157
- Orlova S. E., Ivanova V. A., Degtyarev I. A., Arykhova L. K. et al. Sialometry as a method for diagnosing xerostomia and assessing secretory function (review article) // Bulletin of new medical technologies. 2021. No. 4. P. 52–57. (In Russ) doi: 10.24412/2075-4094-2021-4-1-9.
- Gabardo MCL. Sialometric and sialochemical analysis in individuals with pulp stones. Front. Cell. Dev. Biol. 2020. doi: 10.3389/fcell.2020.00403.
- Shchipsky A.V., Kalimatova M.M., Mukhin P.N. Controlled dynamic sialometry of the parotid glands / Parinsky readings 2022. Innovations in prognosis, diagnostics, treatment and medical rehabilitation of patients with surgical pathology of the craniomaxillofacial region and neck: materials of the National Congress with international participation dedicated to the memory of Professor, Honored Scientist of the Republic of Belarus O.P. Chudakov, May 5-6, 2022, Minsk, Republic of Belarus. (In Russ) eLIBRARY ID: 48796971
- Feifei H., Yuan C., Lu Y., Fangman C., Chuanji W., Yang M., Peiyang Y., Xuemei Q., Xiaadong F., Lu J. Metabolomic insights into idiopathic xerostomia: The central role of caffeine metabolism in salivary biochemistry // Archives of Oral Biology. 2025. Vol.169. P.102-106. (In Russ) DOI:10.1016/j. archoralbio/2024/106102
- Milekhina S.A., Rumyantseva M.P., Poendaeva A.A. Saliva as a biological marker of diseases // "Development of science and education in the context of global instability" Eurasian Scientific Association "ENO" No. 80, October 2021, Moscow, Russia, pp. 1-3. (In Russ) eLIBRARY ID: 47250130.
- Afanasyev V.V., Sirota N.A., Vinokurov N.S. Features of the psychoemotional state of patients suffering from xerostomia // Bulletin of the Kyrgyz State Medical Academy named after I.K. Akhunbaev. 2022. No. 2. pp. 42 - 44. (In Russ) doi: 10.54890/1694-6405_2022_2_42
- Belenov A.I., Kopbaeva M.T., Popova O.B., Smazhko O.A. Xerostomia as an idiopathic symptom in dentistry // Scientific and practical journal. 2023. No. 1 (V. 26). P. 36-41. (In Russ) eLIBRARY ID: 50496645
- Ivankin S.V., Tkacheva Yu.A. Undesirable dental manifestations due to taking various groups of drugs // In the collection: International scientific and practical conference (Students research forum 2022) - Petrozavodsk, 2022. P. 122-132. (In Russ) eLIBRARY ID: 48601760
- Redinova T.L., Chikurova N.V., Lekomtseva Yu.V. Xerostomia syndrome and hyposalivation: severity of manifestation and degree of relationship // Cathedra.2022. No. 81. Pp. 32-36. (In Russ) eLIBRARY ID: 49744978
- Trushnikov N.E., Troshin I.S., Baimukhametova R.D. Oral manifestations in patients with diabetes mellitus // In the collection Science and modern education: current issues, achievements and innovations. Collection of articles of the IV International scientific and practical conference. Penza, 2022. Pp. 247-277. (In Russ) eLIBRARY ID: 47743866
- Khodjaeva M.Yu., Yakubova L.K., Mukhamedov I. Assessment of biochemical factors leading to xerostomia // Internauka. 2021. No. 8-1. pp. 43-47. (In Russ) eLIBRARY ID: 44847268
Supplementary files
