Microcirculation of the salivary glands in patients with sialadenosis and hypogonadism before and after treatment

BACKGROUND: Sialadenoses are often diagnosed as concomitant with certain human diseases. At the initial disease stage, it is not always possible to establish the causative pathological process. Omega-3 fatty acids have great effects on humans. The most important Omega-3 fatty acids are actively involved in the metabolism, are the building materials of cells, and help in the prevention of certain diseases.

AIM: The Omega-3 levels in 20 patients were examined. Moreover, levels of Omega-3 in 20 patients with sialadenosis were measured before and after treatment with Omega-3 to determine the functional activity of the salivary glands depending on the concentrations in the tissues.

MATERIAL AND METHODS: Polyunsaturated Omega-3 fatty acid is the collective name of several fatty acids; although they are not synthesized in the right quantities in humans, they are necessary for maintaining health. The most important Omega-3 fatty acids are actively involved in the metabolism and help in the prevention of cardiovascular diseases, depression, and impaired tissue microcirculation, substantially affecting the human body.

RESULTS: The Omega-3 index before treatment was significantly reduced in all patients with sialadenosis, and it significantly increased (p ≤0.001) after treatment in both women and men. Moreover, the secretory function of the salivary glands significantly improved, the viscosity decreased, and the pH of the mixed saliva was restored.

CONCLUSION: The results of this study revealed normalization of the Omega-3 index level in the erythrocyte membrane after treatment with Omega-3, improvement of the secretory activity of the salivary glands, reduction of viscosity, and restoration of the pH of mixed saliva.