Use of a 1.94-µm Fiber Laser in the Surgical Management of Patients with Oral Epithelial Dysplasia

封面


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

BACKGROUND: The choice of optimal surgical technique for treating potentially malignant oral mucosal disorders with the signs of epithelial dysplasia remains a subject of ongoing debate. This is associated with the absence of a widely adopted method in dental practice that guarantees the most successful outcome. Laser technologies offer improved precision and enhanced therapeutic efficacy for these patients. However, there is a notable lack of studies — both Russian and international — specifically evaluating the use of fiber lasers in managing dysplastic epithelial lesions of the oral mucosa.

CASE DESCRIPTION: This case report presents the surgical excision of oral epithelial dysplasia using a fiber laser, aiming to enhance treatment effectiveness. A 1.94-µm fiber laser was applied in the treatment of verrucous leukoplakia with signs of epithelial dysplasia, which has a malignant transformation rate of up to 65.8%. As a result of the fiber laser treatment, a favorable postoperative period was observed, with no esthetic, functional, or phonetic impairments noted in the long term.

CONCLUSION: A 1.94-µm fiber laser offers high efficacy in the surgical treatment of patients with potentially malignant oral mucosal disorders presenting with epithelial dysplasia.

全文:

受限制的访问

作者简介

Svetlana Tarasenko

First Sechenov Moscow State Medical University

Email: prof_tarasenko@rambler.ru
ORCID iD: 0000-0001-8595-8864
SPIN 代码: 3320-0052

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Moscow

Mikhail Stepanov

First Sechenov Moscow State Medical University

Email: doctor.stepanov@gmail.com
ORCID iD: 0000-0002-1872-9487
SPIN 代码: 6524-5665

MD, Cand. Sci. (Medicine), Associate Professor

俄罗斯联邦, Moscow

Guzel Khisamieva

First Sechenov Moscow State Medical University

编辑信件的主要联系方式.
Email: ggguzelkh@gmail.com
ORCID iD: 0000-0003-0281-7842
SPIN 代码: 1916-7574
俄罗斯联邦, Moscow

Marina Skachkova

First Sechenov Moscow State Medical University

Email: marina.petukhova2014@ya.ru
ORCID iD: 0000-0002-2071-4487
SPIN 代码: 7269-9300
俄罗斯联邦, Moscow

Anastasia Sivodedova

First Sechenov Moscow State Medical University

Email: sivodedovaan@yandex.ru
ORCID iD: 0009-0009-9940-5254
俄罗斯联邦, Moscow

参考

  1. Mello FW, Miguel AFP, Dutra KL, et al. Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis. J Oral Pathol Med. 2018;47(7):633–640. doi: 10.1111/jop.12726
  2. Borgna SC, Clarke PT, Schache AG, et al. Management of proliferative verrucous leukoplakia: Justification for a conservative approach. Head Neck. 2017;39(10):1997–2003. doi: 10.1002/hed.24845
  3. Villa A, Woo SB. Leukoplakia — a diagnostic and management algorithm. J Oral Maxillofac Surg. 2017;75(4):723–734. doi: 10.1016/j.joms.2016.10.012
  4. Tilakaratne WM, Jayasooriya PR, Jayasuriya NS, De Silva RK. Oral epithelial dysplasia: Causes, quantification, prognosis, and management challenges. Periodontol 2000. 2019;80(1):126–147. doi: 10.1111/prd.12259
  5. Ranganathan K, Kavitha L. Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders. J Oral Maxillofac Pathol. 2019;23(1):19–27. doi: 10.4103/jomfp.JOMFP_13_19
  6. Iocca O, Sollecito P, Alawi F, et al. Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype. Head Neck. 2020;42(3):539–555. doi: 10.1002/hed.26006
  7. Kerr AR, Lodi G. Management of oral potentially malignant disorders. Oral Dis. 2021;27:2008–2025. doi: 10.1111/odi.13980 EDN: ZEDTWT
  8. Rodriguez-Lujan A, López-Jornet P, Pons-Fuster López E. Recurrence of oral leukoplakia after CO2 laser resection: a prospective longitudinal study. Cancers (Basel). 2022;14(21):5455. doi: 10.3390/cancers14215455 EDN: BBRFJI
  9. Lodi G, Franchini R, Warnakulasuriya S, et al. Interventions for treating oral leukoplakia to prevent oral cancer. Cochrane Database Syst Rev. 2016;7(7):CD001829. doi: 10.1002/14651858.CD001829.pub4 EDN: WSESMZ
  10. Yang SW, Lee YS, Chang LC, et al. An anatomical perspective on clinicopathological characteristics and treatment outcomes of dorsal and ventrolateral tongue leukoplakia after carbon dioxide laser surgery. BMC Oral Health. 2021;21(1):45. doi: 10.1186/s12903-021-01403-8 EDN: RFRWEE Erratum in: BMC Oral Health. 2021;21(1):70. doi: 10.1186/s12903-021-01430-5
  11. de Pauli Paglioni M, Migliorati CA, Schausltz Pereira Faustino I, et al. Laser excision of oral leukoplakia: Does it affect recurrence and malignant transformation? A systematic review and meta-analysis. Oral Oncol. 2020;109:104850. doi: 10.1016/j.oraloncology.2020.104850 EDN: NHNWWM
  12. Nunez JH, Strong AL, Comish P, et al. A review of laser therapies for the treatment of scarring and vascular anomalies. Adv Wound Care (New Rochelle). 2023;12(2):68–84. doi: 10.1089/wound.2021.0045 EDN: VSYEPP
  13. Zhou S, Zhang X, Liu W, Chen W. Evaluating surgical excision to prevent progression of oral precancerous lesions: Highlighting randomized controlled trials and cohort studies. J Dent Sci. 2023;18(4):1876–1882. doi: 10.1016/j.jds.2023.05.033
  14. Liang F, Xiao Z, Chen R, et al. Transoral 980-nm/1470-nm dual-wavelength fiber laser microsurgery for early-stage glottic carcinoma. Oral Oncol. 2019;96:66–70. doi: 10.1016/j.oraloncology.2019.07.007
  15. Schembri M, Sahu J, Aboumarzouk O, et al. Thulium fiber laser: The new kid on the block. Turk J Urol. 2020;46(Supp. 1):S1–S10. doi: 10.5152/tud.2020.20093 EDN: JPJAYR
  16. Fornaini C, Merigo E, Poli F, et al. Use of 1070 nm fiber lasers in oral surgery: preliminary ex vivo study with FBG temperature monitoring. Laser Ther. 2017;26(4):311–318. doi: 10.5978/islsm.17-OR-21
  17. Pentenero M, Sutera S, Lodi G, et al. Oral leukoplakia diagnosis and treatment in Europe and Australia: Oral Medicine Practitioners’ attitudes and practice. Oral Dis. 2023;29(8):3214–3222. doi: 10.1111/odi.14301 EDN: NAQVIR
  18. Fried NM. Recent advances in infrared laser lithotripsy [Invited]. Biomed Opt Express. 2018;9(9):4552–4568. doi: 10.1364/BOE.9.004552 EDN: YKSCNN
  19. Traxer O, Keller E. Thulium fiber laser: the new player for kidney stone treatment? A comparison with Holmium:YAG laser. World J Urol. 2020;38(8):1883–1894. doi: 10.1007/s00345-019-02654-5
  20. Kronenberg P, Traxer O. The laser of the future: reality and expectations about the new thulium fiber laser — A systematic review. Transl Androl Urol. 2019;8(Suppl. 4):S398–S417. doi: 10.21037/tau.2019.08.01 EDN: VTEUVA

补充文件

附件文件
动作
1. JATS XML
2. Fig. 1. Verrucous leukoplakia of the mucous membrane of the floor of the oral cavity with signs of moderate epithelial dysplasia.

下载 (240KB)
3. Fig. 2. View of the postoperative area immediately after surgery.

下载 (216KB)
4. Fig. 3. Micro preparation of the oral mucosa. Haematoxylin and eosin staining, ×20.

下载 (675KB)
5. Fig. 4. View of the postoperative area on the 3rd day after surgery.

下载 (151KB)
6. Fig. 5. View of the postoperative scar after 1 month.

下载 (212KB)

版权所有 © Eco-Vector, 2025



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 86295 от 11.12.2023 г
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80635 от 15.03.2021 г
.