Synthesis of a New Cobalt Complex with Catechol Dianion and Study of the Kinetics of its Redox-Activated Dissociation

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

A new redox-active cobalt(III) complex with a catechol dianion and two 4,4’-dimethoxy-2,2’-bipyridine ligands was synthesized. The reduction of the complex with ascorbic acid in an inert atmosphere was studied by NMR spectroscopy in situ. The reaction followed the first-order kinetics with respect to the starting complex, had a rate constant of 1.1 × 10−3 s−1, and was accompanied by the release of catechol, which served as a model drug.

About the authors

E. A. Khakina

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Email: khakina90@ineos.ac.ru
Moscow, Russia

I. A. Nikovskii

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Moscow, Russia

A. A. Danshina

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences; Moscow Institute of Physics and Technology (National Research University)

Moscow, Russia; Dolgoprudnyi, Moscow oblast, Russia

E. P. Antoshkina

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences; Moscow Institute of Physics and Technology (National Research University)

Moscow, Russia; Dolgoprudnyi, Moscow oblast, Russia

A. N. Rodionov

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Moscow, Russia

Yu. V. Nelyubina

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Moscow, Russia

References

  1. Vaupel P., Schlenger K., Knoop C. et al. // Cancer Research. 1991. V. 51. P. 3316.
  2. Brown J.M., Wilson W.R. // Nature Reviews Cancer. 2004. V. 4. P. 437.
  3. Denny W.A. // Cancer Invest. 2004. V. 22. P. 604.
  4. Kratz F., Müller I.A., Ryppa C. et al. // ChemMed-Chem. 2008. V. 3. P. 20.
  5. Renfrew A.K. // Metallomics. 2014. V. 6. P. 1324.
  6. Hall M.D., Failes T.W., Yamamoto N. et al. // Dalton Trans. 2007. P. 3983.
  7. Palmeira-Mello M.V., Caballero A.B., Ribeiro J.M. et al. // J. Inorg. Biochem. 2020. V. 211. P. 111211.
  8. Tsitovich P.B., Spernyak J.A., Morrow J.R. // Angew. Chem. Int. Ed. 2013. V. 52. P. 13997.
  9. Teicher B.A., Abrams M.J., Rosbe K.W. et al. // Cancer Res. 1990. V. 50. P. 6971.
  10. Ware D.C., Denny W.A., Clark G.R. // Acta Crystallogr. C. 1997. V. 53. P. 1058.
  11. Failes T.W., Hambley T.W. // Dalton Trans. 2006. V. 1895.
  12. Ahn G-One, Botting K.J., Patterson A.V. et al. // Biochem. Pharmacol. 2006. V. 71. P. 1683.
  13. Chang J.Y-C., Stevenson R.J., Lu G.-L. et al. // Dalton Trans. 2010. V. 39. P. 11535.
  14. Karnthaler-Benbakka C., Groza D., Kryeziu K. et al. // Angew. Chem. Int. Ed. 2014. V. 53. P. 12930.
  15. McPherson J.N., Hogue R.W., Akogun F.S. et al. // Inorg. Chem. 2019. V. 58. P. 2218.
  16. Хакина Е.А., Никовский И.А., Бабакина Д.А. и др. // Коорд. химия. 2023. Т. 49. С. 27
  17. Khakina E.A., Nikovskii I.A., Babakina D.A. et al. // Russ. J Coord Chem 2023. V. 49, № 1. P. 24. https://doi.org/10.1134/S1070328422700105.
  18. Nikovskii I.A., Spiridonov K.A., Dan’shina А.А. et al. // Russ. J. Coord. Chem. 2024. V. 50. P. 195. https://doi.org/10.1134/S1070328423600699
  19. Spiridonov K.A., Nikovskii I.A., Antoshkina E.P. et al. // Russ. J. Coord. Chem. 2024. V. 50. P. 163. https://doi.org/10.1134/S1070328423600663
  20. Vlcek A.A. // Inorg. Chem. 1967. V. 6. P. 1425.
  21. Ma D.-L., Wu‘C., Cheng S.-S. et al. // Int. J. Mol. Sci. 2019. V. 20. P. 341.
  22. Sheldrick G.M. // Acta Crystallogr. A. 2008. V. 64. P. 112.
  23. Dolomanov O.V., Bourhis L.J., Gildea R.J. et al. // J. Appl. Cryst. 2009. V. 42. P. 339.
  24. Stamatatos T.C., Bell A., Cooper P. et.al. // Inorg. Chem. Commun. 2005. V. 8. P. 533.
  25. Alvarez S. // Chem. Rev. 2015. V. 115 P. 13447.
  26. Reddy O.S., Subha M.C.S., Jithendra T. et al. // Int. J. App. Pharm. 2019. V. 11. P. 71.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2025 Российская академия наук