Dental treatment of patients with squamous carcinoma of the oral mucosa

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Abstract

The review presents the impact of modern dental treatment of patients with squamous cell carcinoma of the oral mucosa on the prognosis of dental health after the end of the main antitumor treatment. The literature for the last 5 years was analyzed from the databases PubMed MedLine, The Cochrane Library, EMBASE, Global Health and CyberLeninka platforms, eLibrary.ru. The literature sources taken for the review are indexed in the databases Scopus, Web of Science, RSCI.

The authors conducted a search for modern methods and algorithms of dental treatment for this category of patients. Indications, possible risks and frequent complications of the main types of antitumor treatment and its long-term impact on dental health in general have been identified.

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About the authors

Ekaterina O. Kudasova

I.M. Sechenov First Moscow State Medical University (Sechenovskiy University)

Author for correspondence.
Email: kudasovakat@yahoo.com
ORCID iD: 0000-0002-2603-3834

MD, Dr. Sci. (Med.), Professor

Russian Federation, 2, Bolshaya Pirogovskaya str., 119991, Moscow

Ekaterina V. Kochurova

I.M. Sechenov First Moscow State Medical University (Sechenovskiy University)

Email: evkochurova@mail.ru
ORCID iD: 0000-0002-6033-3427

MD, Dr. Sci. (Med.), Professor

Russian Federation, 2, Bolshaya Pirogovskaya str., 119991, Moscow

Vladimir N. Nikolenko

I.M. Sechenov First Moscow State Medical University (Sechenovskiy University); Lomonosov Moscow State University

Email: vn.nikolenko@yandex.ru
ORCID iD: 0000-0001-9532-9957

MD, Dr. Sci. (Med.), Professor

Russian Federation, 2, Bolshaya Pirogovskaya str., 119991, Moscow; Moscow

Olga I. Panferova

I.M. Sechenov First Moscow State Medical University (Sechenovskiy University)

Email: med_stomat@mail.ru
ORCID iD: 0000-0001-9392-0989

assistant of the department

Russian Federation, 2, Bolshaya Pirogovskaya str., 119991, Moscow

References

  1. old.oncology-association.ru [Internet]. Klinicheskie rekomendatsii Zlokachestvennye novoobrazovaniya polosti rta [cited 14 Feb 2022]. Available from: https://old.oncology-association.ru/files/clinical-guidelines-2020/zno_polosti_rta.pdf
  2. Machiels JP, Rene Leemans C, Golusinski W, et al. Reprint of “Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up”. Oral Oncol. 2021;113:105042. doi: 10.1016/j.oraloncology.2020.105042
  3. de Oliveira TB, Marta GN, de Castro Junior G, Kowalski LP. Induction Chemotherapy for Advanced Oral Cavity Cancer. Curr Oncol Rep. 2021;23(11):129. doi: 10.1007/s11912-021-01119-6
  4. Machiels JP, Rene Leemans C, Golusinski W, et al. Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31(11):1462–1475. doi: 10.1016/j.annonc.2020.07.011
  5. Hong CHL, Hu S, Haverman T, et al. A systematic review of dental disease management in cancer patients. Support Care Cancer. 2018;26(1):155–174. doi: 10.1007/s00520-017-3829-y
  6. Bertolini M, Ranjan A, Thompson A, et al. Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection. PLoS Pathog. 2019;15(4):e1007717. doi: 10.1371/journal.ppat.1007717
  7. Singh S, Singh S, Tiwari MB, et al. Microflora analysis in the postchemotherapy patients of oral cancer. Natl J Maxillofac Surg. 2019;10(2):141–145. doi: 10.4103/njms.NJMS_7_19
  8. Pulito C, Cristaudo A, Porta C, et al. Oral mucositis: the hidden side of cancer therapy. J Exp Clin Cancer Res. 2020;39(1):210. doi: 10.1186/s13046-020-01715-7
  9. Yang D, Zhou F, Fu X, et al. Symptom distress and interference among cancer patients with osteoradionecrosis of jaw: A cross-sectional study. Int J Nurs Sci. 2019;6(3):278–282. doi: 10.1016/j.ijnss.2019.05.006
  10. Suzuki SS, Garcez AS, Reese PO, et al. Effects of corticopuncture (CP) and low-level laser therapy (LLLT) on the rate of tooth movement and root resorption in rats using micro-CT evaluation. Lasers Med Sci. 2018;33(4):811–821. doi: 10.1007/s10103-017-2421-5
  11. Gull FD, Deppe H, Kesting M, Schwarzer C. Periodontal disease-like bone loss after adjuvant radiotherapy in the head and neck region: A case report and review of the literature. Quintessence Int. 2017;48(6):451–457. doi: 10.3290/j.qi.a38161
  12. Moore C, McLister C, O’Neill C, et al. Pre-radiotherapy dental extractions in patients with head and neck cancer: a Delphi study. J Dent. 2020;97:103350. doi: 10.1016/j.jdent.2020.103350
  13. Laverty DP, Addison O, Wubie BA, et al. Outcomes of implant-based oral rehabilitation in head and neck oncology patients-a retrospective evaluation of a large, single regional service cohort. Int J Implant Dent. 2019;5(1):8. doi: 10.1186/s40729-019-0161-y
  14. Schiegnitz E, Al-Nawas B, Kammerer PW, Grotz KA. Oral rehabilitation with dental implants in irradiated patients: a meta-analysis on implant survival. Clin Oral Investig. 2014;18(3):687–698. doi: 10.1007/s00784-013-1134-9
  15. Doll C, Nack C, Raguse JD, et al. Survival analysis of dental implants and implant-retained prostheses in oral cancer patients up to 20 years. Clin Oral Investig. 2015;19(6):1347–1352. doi: 10.1007/s00784-014-1359-2
  16. Wetzels JGH, Meijer GJ, Koole R, et al. Costs and clinical outcomes of implant placement during ablative surgery and postponed implant placement in curative oral oncology: a five-year retrospective cohort study. Clin Oral Implants Res. 2017;28(11):1433–1442. doi: 10.1111/clr.13008
  17. Dziegielewski PT, Bernard S, Mendenhall WM, et al. Osteoradionecrosis in osseous free flap reconstruction: Risk factors and treatment. Head Neck. 2020;42(8):1928–1938. doi: 10.1002/hed.26118
  18. Cotic J, Jamsek J, Kuhar M, et al. Implant-prosthetic rehabilitation after radiation treatment in head and neck cancer patients: a case-series report of outcome. Radiol Oncol. 2017;51(1):94–100. doi: 10.1515/raon-2016-0005
  19. Curi MM, Condezo AFB, Ribeiro K, Cardoso CL. Long-term success of dental implants in patients with head and neck cancer after radiation therapy. Int J Oral Maxillofac Surg. 2018;47(6):783–788. doi: 10.1016/j.ijom.2018.01.012
  20. Mochizuki Y, Harada H, Shimamoto H, et al. Multiple Free Flap Reconstructions of Head and Neck Defects Due to Oral Cancer. Plast Reconstr Surg Glob Open. 2017;5(6):e1337. doi: 10.1097/GOX.0000000000001337
  21. Khanna D, Chaubal T, Bapat R, et al. Carcinoma ex pleomorphic adenoma: a case report and review of literature. Afr Health Sci. 2019;19(4):3253–3263. doi: 10.4314/ahs.v19i4.50
  22. Haubner F, Ohmann E, Pohl F, et al. Wound healing after radiation therapy: review of the literature. Radiat Oncol. 2012;7:162. doi: 10.1186/1748-717X-7-162
  23. Roche NA, Houtmeyers P, Vermeersch HF, et al. The role of the internal mammary vessels as recipient vessels in secondary and tertiary head and neck reconstruction. J Plast Reconstr Aesthet Surg. 2012;65(7):885–892. doi: 10.1016/j.bjps.2012.01.006
  24. Vahidi N, Lee TS, Daggumati S, et al. Osteoradionecrosis of the Midface and Mandible: Pathogenesis and Management. Semin Plast Surg. 2020;34(4):232–244. doi: 10.1055/s-0040-1721759
  25. Samet N, Jotkowitz A. Classification and prognosis evaluation of individual teeth – a comprehensive approach. Quintessence Int. 2009;40(5):377–387.
  26. Sroussi HY, Epstein JB, Bensadoun RJ, et al. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 2017;6(12):2918–2931. doi: 10.1002/cam4.1221
  27. Kawashita Y, Soutome S, Umeda M, Saito T. Oral management strategies for radiotherapy of head and neck cancer. Jpn Dent Sci Rev. 2020;56(1):62–67. doi: 10.1016/j.jdsr.2020.02.001
  28. Atif S, Wahab NA, Ghafoor S, et al. Salivary and imaging-based biomarkers of radiation therapy-induced xerostomia. J Pak Med Assoc. 2021;71(3):938–942. doi: 10.47391/JPMA.1115
  29. Chukhlovin AB, Grigoriants AP. Pathology of oral mucosa after intensive chemoradiotherapy (review). Klinicheskaja stomatologija. 2018(3):39–43. (In Russ). doi: 10.37988/1811-153x_2018_3_39
  30. Syomkin VA, Nadtochiy AG, Kuzin AV, et al. [Clinical and radiological features of inflammatory lesions in the lower molars area]. Stomatologiya. 2017;96(5):43–47. (In Russ). doi: 10.17116/stomat201796543-47
  31. Lan XY, Chung TT, Huang CL, et al. Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis. Biomolecules. 2020;10(9). doi: 10.3390/biom10091321
  32. Baliga MS, Rao S, Hegde SK, et al. Usefulness of Honey as an Adjunct in the Radiation Treatment for Head and Neck Cancer: Emphasis on Pharmacological and Mechanism/s of Actions. Anticancer Agents Med Chem. 2022;22(1):20–29.doi: 10.2174/1871520621666210126094509
  33. Faustova MO, Nazarchuk OA, Ananieva MM. The etiological structure, biological properties of causative agents of peri-implant mucositis. Zaporozhye Medical Journal. 2017;19(5):652–657. (In Russ). doi: 10.14739/2310-1210.2017.5.110226
  34. Kudva AK, Raghu SV, Rao S, et al. Indian Indigenous Fruits as Radioprotective Agents: Past, Present and Future. Anticancer Agents Med Chem. 2022;22(1):53–63. doi: 10.2174/1871520621666210706124315
  35. Glick A, Sista V, Johnson C. Oral Manifestations of Commonly Prescribed Drugs. Am Fam Physician. 2020;102(10):613–621.
  36. Sleibi A, Tappuni AR, Baysan A. Reversal of Root Caries with Casein Phosphopeptide-Amorphous Calcium Phosphate and Fluoride Varnish in Xerostomia. Caries Res. 2021;55(5):475–484. doi: 10.1159/000516176
  37. Berrone M, Lajolo C, De Corso E, et al. Cooperation between ENT surgeon and dentist in head and neck oncology. Acta Otorhinolaryngol Ital. 2021;41(Suppl. 1):S124–S137. doi: 10.14639/0392-100X-suppl.1-41-2021-13
  38. Kochurova EV, Nikolenko VN. Matrixins in the salivary fluid of patients with tumors of the maxillofacial region during orthopedic rehabilitation with different prosthetic structures. Bulletin of Experimental Biology and Medicine. 2017;163(5):622–625. (In Russ).
  39. Martin P, Muller E, Paulus C. Alteration of facial growth after radiotherapy: orthodontic, surgical and prosthetic rehabilitation. J Stomatol Oral Maxillofac Surg. 2019;120(4):369–372. doi: 10.1016/j.jormas.2019.04.004
  40. Navarro Cuellar C, Tousidonis Rial M, Antunez-Conde R, et al. Functional Outcomes with Facial Artery Musculo-Mucosal (FAMM) Flap and Dental Implants for Reconstruction of Floor of the Mouth and Tongue Defects in Oncologic Patients. J Clin Med. 2021;10(16). doi: 10.3390/jcm10163625
  41. van Baar GJC, Leeuwrik L, Lodders JN, et al. A Novel Treatment Concept for Advanced Stage Mandibular Osteoradionecrosis Combining Isodose Curve Visualization and Nerve Preservation: A Prospective Pilot Study. Front Oncol. 2021;11:630123. doi: 10.3389/fonc.2021.630123
  42. Ernst N, Sachse C, Raguse JD, et al. Changes in Peri-Implant Bone Level and Effect of Potential Influential Factors on Dental Implants in Irradiated and Nonirradiated Patients Following Multimodal Therapy Due to Head and Neck Cancer: A Retrospective Study. J Oral Maxillofac Surg. 2016;74(10):1965–1973. doi: 10.1016/j.joms.2016.06.005
  43. Yoon HI. Prosthetic Rehabilitation After Fibular Free Flap Surgery of Mandibular Defects in a Patient With Oral Squamous Cell Carcinoma. J Craniofac Surg. 2016;27(7):e685–e688. doi: 10.1097/SCS.0000000000002761
  44. Bel’skaya LV, Sarf EA, Solomatin DV, Kosenok VK. Diagnostic and Prognostic Value of Salivary Biochemical Markers in Oral Squamous Cell Carcinoma. Diagnostics (Basel). 2020;10(10). doi: 10.3390/diagnostics10100818
  45. Okuma S, Osako R, Ishizuka S, et al. A Case of Early Detection and Treatment Applicable to Squamous Cell Carcinoma of the Palate Detected by Oral Cancer Mass Screening in Izumo 2019. Gan To Kagaku Ryoho. 2020;47(13):1774–1776.
  46. Yang ES, Deutsch E, Mehmet A, et al. A Phase 1b trial of prexasertib in combination with chemoradiation in patients with locally advanced head and neck squamous cell carcinoma. Radiother Oncol. 2021;157:203–209. doi: 10.1016/j.radonc.2021.01.032
  47. Zeng L, Nikolaev A, Xing C, et al. CHK1/2 Inhibitor Prexasertib Suppresses NOTCH Signaling and Enhances Cytotoxicity of Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma. Mol Cancer Ther. 2020;19(6):1279–1288. doi: 10.1158/1535-7163.MCT-19-0946
  48. Gulati S, Desai J, Palackdharry SM, et al. Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer. Cancer. 2020;126(2):354–362.doi: 10.1002/cncr.32539
  49. Hintelmann K, Berenz T, Kriegs M, et al. Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells. Front Oncol. 2021;11:683688. doi: 10.3389/fonc.2021.683688

Supplementary files

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2. Fig. 1. Guidelines for the treatment of patients with squamous cell carcinoma of the oral mucosa [4].

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3. Fig. 2. Pathobiology of the onset of mucositis: (a) normal tissue, (b) the response of the oral mucosa to the primary injury (initiation phase), (c) increased damage signal, (d) ulceration, (e) tissue epithelization [8].

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