Experimental justification for the application of different methods for oral mucosal wound closure

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The current study analyzed Russian and foreign scientific evidence on oral mucosal regeneration published over the period between 2000 and 2020. The Central Scientific Medical Library, electronic Medical library (elibrary.ru), and the scientific database PubMed were searched for relevant experimental studies focusing on methods used to stimulate healing of excisional wounds in the palate. The aim of the review was to identify the most effective method of oral mucosal wound closure. The findings showed that the successful introduction of new methods for oral mucosal wound closure with reliable treatment outcomes was dependent on accurate experimental, laboratory, and histological substantiation of their effectiveness.

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About the authors

Svetlana V. Tarasenko

First Sechenov Moscow State Medical University (Sechenov university)

Author for correspondence.
Email: prof_tarasenko@rambler.ru
ORCID iD: 0000-0001-8595-8864

MD, Dr. Sci. (Med.), Professor

Russian Federation, build. 2, 8, Trubetskaya str., 119991, Moscow

Natalia A. Blagushina

First Sechenov Moscow State Medical University (Sechenov university)

Email: blagushina.natalia@yandex.ru
ORCID iD: 0000-0002-5839-7915

assistant of the department

Russian Federation, build. 2, 8, Trubetskaya str., 119991, Moscow

Anna M. Ershova

First Sechenov Moscow State Medical University (Sechenov university)

Email: annushka1412@mail.ru
ORCID iD: 0000-0001-9266-846X

MD, Cand. Sci. (Med.)

Russian Federation, build. 2, 8, Trubetskaya str., 119991, Moscow

Suriyana U. Balgaeva

First Sechenov Moscow State Medical University (Sechenov university)

Email: suriyana-98@mail.ru


Russian Federation, build. 2, 8, Trubetskaya str., 119991, Moscow


  1. Durnovo EA, Riabova DA, Orlinskaya NYu, Khomutinnikova NE. Experimental and clinical study of the effectiveness of polymeric membrane in surgical interventions on the oral mucosa. Stomatologiia. 2018;97(5):48–53. (In Russ). doi: 10.17116/stomat20189705148
  2. Tirskaya OI, Kazankova EM, Bolshedvorskaya NE, Byvaltseva SYu, Fedotova MV. The gel-like coating application based on poviargol in treatment of traumatic lesions of the oral mucosa. Рarodontologija. 2018;23(3):35–38. (In Russ). doi: 10.25636/PMP.1.2018.3.5
  3. Tancharoen S, Gando S, Binita S, et al. HMGB1 Promotes Intraoral Palatal Wound Healing through RAGE-Dependent Mechanisms. Int J Mol Sci. 2016;17(11). doi: 10.3390/ijms17111961
  4. Yaghobee S, Rouzmeh N, Aslroosta H, et al. Effect of Topical Erythropoietin (EPO) on palatal wound healing subsequent to Free Gingival Grafting (FGG). Braz Oral Res. 2018;32:e55. doi: 10.1590/1807-3107bor-2018.vol32.0055
  5. Lee K, Ben Amara H, Lee SC, et al. Chemical Regeneration of Wound Defects: Relevance to the Canine Palatal Mucosa and Cell Cycle Up-Regulation in Human Gingival Fibroblasts. Tissue Eng Regen Med. 2019;16(6):675–684. doi: 10.1007/s13770-019-00227-6
  6. Zorina OA, Molchanov AM, Balykin RA. Indication and technique of human fibrinogen/thrombin-coated collagen patch use in mucogingival surgery. Stomatologiia. 2014; 93(4):48–51. (In Russ).
  7. Volozhin AI, Gemonov VV, Kabaloeva DV, Surazhev BY. Healing of surgical wound in oral mucosa after the treatment with recombinant epidermal growth factor in experiment. Rossijskaya stomatologiia. 2011;4(1):32–37. (In Russ).
  8. Morozov AM, Sergeev AN, Sergeev NA, et al. Modern methods of stimulating the regeneration process of postoperative wounds. Sibirskoe medicinskoe obozrenie. 2020;3:7. (In Russ). doi: 10.20333/2500136-2020-3-54-60
  9. Ryabova DA, Orlinskaya NY, Tsybusov SN, et al. Application of polymer phospholipid matrix for closing open wounds on oral mucosa. Sovremennye technologii v medicine. 2016;8(1):55–63. (In Russ). doi: 10.17691/stm2016.8.1.08
  10. Zhmailik RR, Bogdan VG, Korneva YS, Dorosevich AE. Morphological Features of Wound Regeneration in the Local Application of Recombinant Interferon α2В in the Experiment. Vestnik of experimental and clinical surgery. 2017;10(3):225–230. (In Russ). doi: 10.18499/2070-478X-2017-10-3-225-230
  11. Tamaki N, Orihuela-Campos RC, Fukui M, Ito HO. Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model. Oxid Med Cell Longev. 2016;2016:5679040. doi: 10.1155/2016/5679040
  12. Keskiner I, Lutfioglu M, Aydogdu A, et al. Effect of Photobiomodulation on Transforming Growth Factor-beta1, Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study. Photomed Laser Surg. 2016;34(6):263–271. doi: 10.1089/pho.2016.4094
  13. Fujita T, Yoshimoto T, Matsuda S, et al. Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells. J Periodontal Res. 2015;50(4):479–485. doi: 10.1111/jre.12230
  14. Kikuchi K, Uchikado H, Miura N, et al. HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development. Exp Ther Med. 2011;2(5):767–770. doi: 10.3892/etm.2011.310
  15. Shabashova NV, Danilova EU. Mucosal immunity and oral microbiota (review). Problemy medicinskoj mikologii. 2015;17(4):4–13. (In Russ).
  16. Zhu T, Park HC, Son KM, Yang HC. Effects of dimethyloxalylglycine on wound healing of palatal mucosa in a rat model. BMC Oral Health. 2015;15:60. doi: 10.1186/s12903-015-0047-1
  17. Vinnik YS, Salmina AB, Teplyakova OV, et al. Dynamics of local expression of connexin-43 and basic fibroblast growth factor receptors in patients with skin and soft-tissue infections against the background of diabetes mellitus type II. Vestnik hirurgii im. I.I. Grekova. 2014;173(4):47–52. (In Russ).
  18. Agis H, Watzek G, Gruber R. Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts. J Periodontal Res. 2012;47(2):165–173. doi: 10.1111/j.1600-0765.2011.01415.x
  19. Bodo E, Kromminga A, Funk W, et al. Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin. FASEB J. 2007;21(12):3346–3354. doi: 10.1096/fj.07-8628com
  20. Hamed S, Ullmann Y, Egozi D, et al. Fibronectin potentiates topical erythropoietin-induced wound repair in diabetic mice. J Invest Dermatol. 2011;131(6):1365–1374. doi: 10.1038/jid.2011.15
  21. Ohta S. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther. 2014;144(1):1–11. doi: 10.1016/j.pharmthera.2014.04.006
  22. Mahmoudi H, Balighi K, Tavakolpour S, et al. Trichloroacetic acid as a treatment for persistent oral mucosal lesions in pemphigus vulgaris. J Am Acad Dermatol. 2019;80(3):e51–e52. doi: 10.1016/j.jaad.2018.08.039
  23. Sezgin Y, Bilgin Cetin M, Bulut S, et al. Evaluating the Effects of a Topical Preparation with Dexpanthenol, Silbiol, Undecylenic Acid, and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model. Balkan Med J. 2019;36(2):88–95. doi: 10.4274/balkanmedj.galenos.2018.2018.0167
  24. Kadkhoda Z, Tavakoli A, Chokami Rafiei S, et al. Effect of Amniotic Membrane Dressing on Pain and Healing of Palatal Donor Site: A Randomized Controlled Trial. Int J Organ Transplant Med. 2020;11(2):55–62. doi: PMC7430060
  25. Sementsov IV, Peshko AP, Goman MY. Closing a donor site of a palate autograft with a fibrin membrane. Pacific Medical Journal. 2020;2:92–93. doi: 10.34215/1609-1175-2020-2-92-93 (In Russ).
  26. Belkhede SG, Salaria SK, Aggarwal R. Comparative evaluation of the platelet-rich fibrin bandage versus gelatin sponge-assisted palatal wound healing of free gingival graft donor site: A case series. J Indian Soc Periodontol. 2019;23(6):589–592. doi: 10.4103/jisp.jisp_165_19
  27. Martelloni M, Montagner G, Trojan D, Abate R. Amniotic Membrane In Palatal Epithelial-Connective Tissue Reconstruction. Int Med Case Rep J. 2019;12:349–354. doi: 10.2147/IMCRJ.S213275
  28. Amemiya T, Nakamura T, Yamamoto T, et al. Autologous transplantation of oral mucosal epithelial cell sheets cultured on an amniotic membrane substrate for intraoral mucosal defects. PLoS One. 2015;10(4):e0125391. doi: 10.1371/journal.pone.0125391
  29. Karadag A, Ozdemir R, Kurt A, et al. Protective effects of dexpanthenol in an experimental model of necrotizing enterocolitis. J Pediatr Surg. 2015;50(7):1119–1124. doi: 10.1016/j.jpedsurg.2014.10.053
  30. Ushakov RV, Gerasimova TP, Nikolaev VA. Immunomodulating activity of adhesive dental film containing chlorhexidine and ketoprofen in serum of patients with chronic periodontitis. Stomatologiia. 2019;98(5):6–10. (In Russ). doi: 10.17116/stomat2019980516

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