Role of human papillomavirus infection in the development of oral leukoplakia and oral squamous cell carcinoma

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

BACKGROUND: The annual global oral cancer morbidity is more than 650,000 cases. Between 2007 and 2017 in the Russian Federation, the absolute number of first-ever diagnosed oral cavity malignant neoplasms is constantly increasing. According to many authors, oral squamous cell carcinoma is associated with pre-existing leukoplakia. This disease is the most common and prone to malignant precancerous oral mucosa disease. Human papillomaviruses (HPV) are crucial players in this process. However, the relationship between HPV infection in leukoplakia and oral squamous cell carcinoma remains unclear.

AIM: To establish the HPV role in the development of leukoplakia and squamous cell carcinoma of the oral mucosa.

MATERIAL AND METHODS: The study included 39 patients with verified various forms of oral leukoplakia and oral squamous cell carcinomas. The squamous cell carcinoma group included 19 patients. The oral leukoplakia group is consisted of 20 patients. The control group of healthy volunteers is represented by 22 patients with clinically healthy oral mucosa. HPV deoxyribonucleic acid (DNA) was detected and quantified in clinical materials by polymerase chain reaction with hybridization-fluorescence detection “AmpliSense® HPV HRS screen-titer-FL” for HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 and “AmpliSense® HPV 6/11-FL” for HPV types 6 and 11.

RESULTS: HPV types 6 and 11 DNA were isolated in three cases with insignificant clinical disease from 19 samples taken from patients with oral squamous cell carcinoma. In groups of leukoplakia and healthy volunteers, no high oncological risk was identified. Despite a HPV-positive expression in squamous cell carcinoma samples is detected, no significant difference was found between the squamous cell carcinoma group and control group (p=0.09).

CONCLUSION: No significant association was noted between HPV and oral squamous cell carcinoma; however, a low carcinogenic-risk HPV was detected in 15.7% of carcinoma samples. No HPV contamination was detected in patients with leukoplakia and healthy groups.

Full Text

Restricted Access

About the authors

Dmitry E. Mikhalev

Siberian State Medical University

Author for correspondence.
Email: dm199412@gmail.com
ORCID iD: 0000-0002-0647-3576

Postgraduate Student

Russian Federation, Tomsk

Olga D. Baydik

Siberian State Medical University

Email: olgabajdik@yandex.ru
ORCID iD: 0000-0002-4748-4175

MD, Dr. Sci. (Med.), Professor

Russian Federation, Tomsk

Marat R. Mukhamedov

Siberian State Medical University; Cancer Research Institute, Tomsk National Research Medical Center

Email: muhamedov@oncology.tomsk.ru
ORCID iD: 0000-0003-1555-050X

MD, Dr. Sci. (Med.), Leading Researcher

Russian Federation, Tomsk; Tomsk

Marina V. Chebakova

Siberian State Medical University

Email: hertek81@mail.ru

MD, Cand. Sci. (Med.)

Russian Federation, Tomsk

Marina K. Ibragimova

Cancer Research Institute, Tomsk National Research Medical Center

Email: imk1805@yandex.ru

MD, Cand. Sci. (Biol.)

Russian Federation, Tomsk

References

  1. Dhull AK, Atri R, Dhankhar R, et al. Major risk factors in head and neck cancer: a retrospective analysis of 12-year experiences. World J Oncol. 2018;9: 80–84. doi: 10.14740/wjon1104w
  2. Kaprin VV, Starinsky GV, Petrova GV, editors. Malignant neoplasms in Russia in 2018 (morbidity and mortality). Moscow: MNIOI; 2019. 250 p. (In Russ).
  3. Erugula SR, Farooq MU, Jahagirdar D, et al. Oral leukoplakia etiology, risk factors, molecular pathogenesis, prevention and treatment: a review. IInt J Environ Res Public Health. 2020;7(11):K1–K5.
  4. Abati S, Bramati C, Bondi S, et al. Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis. Int J Contemp Med Res. 2020;17(24):9160. doi: 10.3390/ijerph17249160
  5. Saldivia-Siracusa C, González-Arriagada WA. Difficulties in the Prognostic Study of Oral Leukoplakia: Standardisation Proposal of Follow-Up Parameters. Front Oral Health. 2021;2:614045. doi: 10.3389/froh.2021.614045
  6. Rodriguez-Archilla A, Garcia-Gamez MT. Risk Factors for Oral Leukoplakia: A Meta-Analysis. J Res Notes. 2018;1(1):1001.
  7. Rusinovci S, Aliu X, Jukić T, et al. Analysis of THREE-year prevalence of oral cavity, neck and head tumors – a retrospective single-centre study. Acta Clinica Croatica. 2020;59(3):445–454. doi: 10.20471/acc.2020.59.03.08
  8. Dvoryaninova OY, Choinzonov EL, Litvyakov NV. Clinical aspects of HPV-positive oral and oropharyngeal employment. Bulletin of Otorhinolaryngology. 2016;81(1):72–77. (In Russ). doi: 10.17116/otorino201681172-77
  9. Saghravanian N, Ghazi N, Meshkat Z, Mohtasham N. Human Papillomavirus in Oral Leukoplakia, Verrucous Carcinoma, Squamous Cell Carcinoma, and Normal Mucous Membrane. Oman Med J. 2015;30(6):455–460. doi: 10.5001/omj.2015.89
  10. Sushma C, Birur NP, Suresh A, et al. Detection of HPV16 in tissues of oral leukoplakia by polymerase chain reaction and p16 immunohistochemistry: A prospective study. Transl Res Oral Oncol. 2017;2(1):2057178X1771388. doi: 10.1177/2057178X17713880
  11. Panneerselvam K, Rameshkumar A, Rajkumar K, Ramadoss R. Detection of human papillomavirus 16 and 18 in patients with oral squamous cell carcinoma and potentially malignant oral disorders in South Indian population: A pilot study. J Cancer Res Ther. 2019;15(3):571–575. doi: 10.4103/jcrt.JCRT_1012_17
  12. Alahakoon PKDPP, Perera KA, Pannala WS. Human papillomavirus (HPV) associated oral cavity and oropharyngeal cancers: Cross-sectional follow-up study in South Asian country, Sri Lanka. Ann Oncol. 2018;2929(Suppl. 9):IX104. doi: 10.1093/annonc/mdy438.034
  13. Menezes FDS, Latorre MDRDO, Conceição GMS, et al. The emerging risk of oropharyngeal and oral cavity cancer in HPV-related subsites in young people in Brazil. PLoS One. 2020;15(5):e0232871. doi: 10.1371/journal.pone.0232871
  14. Bano N, Yadav M, Mohania D, Das BC. The role of NF-κB and miRNA in oral cancer and cancer stem cells with or without HPV16 infection. PLoS One. 2018;13(10):e0205518. doi: 10.1371/journal.pone.0205518
  15. Wu W, Wang Z, Zhou Z. Role of the human papillomavirus in malignant transformation of oral leukoplakia distinct from oropharyngeal squamous cell carcinoma: A study of 76 patients with internal-control specimens. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;128(3):273–279. doi: 10.1016/j.oooo.2019.01.004
  16. Shang Q, Peng J, Zhou Y, et al. Association of Human Papillomavirus With Oral Lichen Planus and Oral Leukoplakia: A Meta-analysis. J Evid Based Dent Pract. 2020;20(4):101485. doi: 10.1016/j.jebdp.2020.101485
  17. Santacroce L, Di Cosola M, Bottalico L, et al. Focus on HPV Infection and the Molecular Mechanisms of Oral Carcinogenesis. Viruses. 2021;13(4):559. doi: 10.3390/v13040559
  18. Gupta S, Gupta S. Role of human papillomavirus in oral squamous cell carcinoma and oral potentially malignant disorders: A review of the literature. Indian J Dent. 2015;6(2):91–98. doi: 10.4103/0975-962X.155877
  19. Ramírez-Pérez FA. The role of human papillomavirus in oral squamous cell carcinoma. Plast Aesthet Res. 2019;128(3):273–279. doi: 10.20517/2347-9264.2016.17

Copyright (c) 2022 Eco-Vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: 015648 от 14.05.1999 г
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80635 от 15.03.2021 г
.



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies