Effect of a new domestic remedy for fixation of removable dentures on oral mucosal immunity

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


BACKGROUND: The persisting high incidence of complications in removable acrylic dentures should convince the researchers to understand the consequences of denture use on the oral health and whole organism.

AIM: To examine the peculiarities of the oral mucosal immunity in patients with partial removable acrylic dentures and to evaluate the efficacy of the application of Asepta Prodontal denture fixation agent.

MATERIAL AND METHODS: Mucosal immunity was studied in 93 (24 men and 69 women) elderly patients (aged 61– 74 years) with partial tooth loss who were divided into three study groups. Patients in the control group 1 (n=30) did not use any dentures. Group 2 (n=33) had partial removable acrylic dentures and from the first day of the adaptation period were offered to use the domestic denture fixation cream Asepta Parodontal (ZAO “VERTEX,” Saint Petersburg, Russia). Partial removable acrylic dentures were also made for group 3 (n=30), but their adaptation period was conducted without the application of domestic Asepta Parodontal denture fixation cream.

RESULTS: On day 15 of the adaptation period in groups 2 and 3, inflammatory changes in the denture bed mucosa were revealed in 9.1% and 56.7% of the cases, respectively. On day 30 of dynamic observation in groups 2 and 3, inflammatory changes in the prosthetic bed mucosa were noted in 6.1% and 40.0% of the cases, respectively. The average numbers of visits to the doctor for denture correction in groups 2 and 3 were 1.33 and 2.76, respectively. A significant increase was found in the levels of pro-inflammatory cytokines on day 15 of the study in the saliva of patients with removable dentures, who used them without the denture fixation agent Asepta Parodontal, whereas patients using Asepta Parodontal showed an increase only in interleukins (IL) 6 and 8. Moreover, on day 30 of the study, no differences from the control group were observed in the concentration of pro-inflammatory cytokines compared with the group using domestic denture fixation cream, and in the group without using the cream, no decrease in the level of pro-inflammatory cytokines was noted. The concentration of RAIL and IL-10 increased in group 3 on both day 15 and 30, whereas no significant differences were observed in the group using the cream.

CONCLUSION: Better prosthetic bed condition, decreased concentration of pro-inflammatory cytokines with a simultaneous elevation of secretory IgA in the oral cavity, testifying to the decrease in inflammation, and an increase in the immunity of the oral mucosa was noted in patients using Asepta Parodontal denture fixation agent.

Full Text

Restricted Access

About the authors

Mikhail E. Malyshev

Saint Petersburg State University; Research Institute of Emergency Medicine named after I.I. Dzhanelidze

Email: Malyshev1972@yandex.ru
ORCID iD: 0000-0001-7549-682X

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg; Saint Petersburg

Kamil A. Kerimkhanov


Email: 1yadakamil@mail.ru
ORCID iD: 0000-0002-9149-2631
Russian Federation, Saint Petersburg

Andrey K. Iordanishvili

Military Medical Academy named after S.M. Kirov

Author for correspondence.
Email: professoraki@mail.ru
ORCID iD: 0000-0003-0052-3277

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg


  1. Griffin SO, Jones JA, Brunson D, Griffin PM, Bailey WD. Burden of oral disease among older adults and implications for public health priorities. American J Public Health. 2012;102(3):411–418. doi: 10.2105/AJPH.2011.300362
  2. Iordanishvili AK. Geriatric dentistry: a handbook. Saint Petersburg: Chelovek; 2019. 348 p. (In Russ).
  3. Gendreau L, Loewy ZG. Epidemiology and etiology of denture stomatitis. J Prosthodont. 2011;20(4):251–260. doi: 10.1111/j.1532-849X.2011.00698.x
  4. Malyshev ME, Lobeiko VV, Iordanishvili AK. Indicators of secretory immunity of saliva in patients with various diseases of the salivary glands. Kursk scientific and practical newsletter “Man and His Health”. 2015;(1):40–48. (In Russ).
  5. Dawes C. Salivary flow patterns and the health of hard and soft oral tissues. J Am Dent Assoc. 2008;139:18S–24S. doi: 10.14219/jada.archive.2008.0351
  6. Brandtzaeg P. Do salivary antibodies reliably reflect both mucosal and systemic immunity? Ann N Y Acad Sci. 2007;1098:288–311. doi: 10.1196/annals.1384.012

Supplementary files

Supplementary Files
1. Fig. 1. Number of patients and their gender in the study groups, persons

Download (89KB)
2. Fig. 2. Incidence of inflammatory processes of prosthetic bed tissues in patients of groups 2 and 3 in different terms of the adaptation period

Download (112KB)
3. Fig. 3. Number of visits for denture correction of patients in groups 2 and 3 of the study during the adaptation period, n

Download (48KB)
4. Fig. 4. Concentration of proinflammatory cytokines in saliva in the studied groups (% of normal)

Download (120KB)
5. Fig. 5. Concentration of anti-inflammatory cytokines in saliva in the studied groups (% of normal)

Download (129KB)
6. Fig. 6. Concentration of saliva immunoglobulin A in saliva in the studied groups (% of normal)

Download (117KB)

Copyright (c) 2022 Eco-Vector

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: 015648 от 14.05.1999 г
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80635 от 15.03.2021 г

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies