Application of a computer program in the assessment of psychological parameters of patients with lichen planus of the oral mucosa

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BACKGROUND: The relevance of the study of oral lichen planus (OLP) does not raise doubts given the unclear etiological nature of this dermatitis, potential for malignancy, and difficulty in performing therapeutic measures.

AIM: To assess the psychoemotional state of patients with various forms of OLP using a computer program (ConScale).

MATERIAL AND METHODS: We examined 287 patients with a verified diagnosis of OLP. The average age of the patients was 47.8±9.0 years; men, 121 (42.1%); women, 166 (57.9%).

RESULTS: Psychological parameters were assessed using ConScale according to the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI). In comparison with the control group (n=32) of comparable age and sex according to BAI and BDI, significant differences were found in patients with erosive-ulcerative, exudative-hyperemic, and bullous forms of LP. A relationship was found between these clinical forms of OLP and psychological conditions such as anxiety and depression.

CONCLUSION: The results indicate the need to include psychological testing of patients with OLP in the protocol for a comprehensive assessment of the patient’s condition and treatment with individually selected sedatives.

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Marat N. Vildanov

Bashkir State Medical University

Author for correspondence.
ORCID iD: 0000-0003-3050-6304

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, Ufa, Republic of Bashkortostan

Larisa P. Gerasomova

Bashkir State Medical University

ORCID iD: 0000-0002-1145-6500

MD, Dr. Sci. (Med.), Professor

Russian Federation, Ufa, Republic of Bashkortostan

Tatiana S. Chemikosova

Bashkir State Medical University

ORCID iD: 0000-0002-9427-2116

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, Ufa, Republic of Bashkortostan

Anna A. Golub

Bashkir State Medical University

ORCID iD: 0000-0003-1996-1197

MD, Cand. Sci. (Med), Associate Professor

Russian Federation, Ufa, Republic of Bashkortostan


  1. Shavit E, Hagen K, Shear N. Oral lichen planus: a novel staging and algorithmic approach and all that is essential to know. F1000Res. 2020;9:206. doi: 10.12688/f1000research.18713.1
  2. Chiang CP, Yu-Fong Chang J, Wang YP, et al. Oral lichen planus — Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management. J Formos Med Assoc. 2018;117(9):756–765. doi: 10.1016/j.jfma.2018.01.021
  3. Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, Tomov GT. Oral Lichen Planus — Known and Unknown: a Review. Folia Med (Plovdiv). 2018;60(4):528–535. doi: 10.2478/folmed-2018-0017
  4. Garcia-Pola MJ, Llorente-Pendás S, González-Garcia M, García-Martín JM. The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study. Med Oral Patol Oral Cir Bucal. 2016;21(3):e328–334. doi: 10.4317/medoral.20832
  5. Greenberg MS. AAOM Clinical Practice Statement: Subject: Oral lichen planus and oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(4):440–441. doi: 10.1016/j.oooo.2016.05.015
  6. Tampa M, Caruntu C, Mitran M, et al. Markers of Oral Lichen Planus Malignant Transformation. Dis Markers. 2018:1959506. doi: 10.1155/2018/1959506
  7. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, et al. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021;26(4):e541–e548. doi: 10.4317/medoral.24610
  8. Rotaru DI, Sofineti D, Bolboacă SD, Bulboacă AE. Diagnostic Criteria of Oral Lichen Planus: A Narrative Review. Acta Clin Croat. 2020;59(3):513–522. doi: 10.20471/acc.2020.59.03.16
  9. Boñar-Alvarez P, Pérez Sayáns M, Garcia-Garcia A, et al. Correlation between clinical and pathological features of oral lichen planus: A retrospective observational study. Medicine (Baltimore). 2019;98(8):e14614. doi: 10.1097/MD.0000000000014614
  10. González-Moles MÁ, Ramos-García P, Warnakulasuriya S. An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review. Oral Dis. 2020;27(8):1908–1918. doi: 10.1111/odi.13741
  11. Georgescu SR, Mitran CI, Mitran MI, et al. Oxidative Stress in Cutaneous Lichen Planus-A Narrative Review. J Clin Med. 2021;10(12):2692. doi: 10.3390/jcm10122692
  12. Wang J, Yang J, Wang C, et al. Systematic Review and Meta-Analysis of Oxidative Stress and Antioxidant Markers in Oral Lichen Planus. Oxid Med Cell Longev. 2021:9914652. doi: 10.1155/2021/9914652
  13. Surdina ED, Simbirtsev AS, Kruchina-Bogdanov IV, et al. Lichen planus of the oral mucosa: correlation between indicators of oxidative changes in the mucous membrane and disorders of the fatty acid composition of the blood of patients. Bulletin of the North-Western State Medical University named after I.I. Mechnikov. 2016;8(3):62–68. (In Russ).
  14. Melnik TV, Bondar SA. Influence of complex therapy on indicators of oxidative stress markers in patients with lichen planus. Ukrainian Journal of Dermatology, Venereology, Cosmetology. 2019;(2):45–49. (In Russ). doi: 10.30978/UJDVK2019-2-45
  15. Jalenques I, Lauron S, Almon S, et al. Prevalence and Odds of Signs of Depression and Anxiety in Patients with Lichen Planus: Systematic Review and Meta-analyses. Acta Derm Venereol. 2020;100(18):adv00330. doi: 10.2340/00015555-3660
  16. Mehdipour M, Taghavi Zenouz A, Farnam A, et al. The Relationship between Anger Expression and Its Indices and Oral Lichen Planus. Chonnam Med J. 2016;52(2):112–116. doi: 10.4068/cmj.2016.52.2.112
  17. Cassol-Spanemberg J, Blanco-Carrion A, Rodriguez-de Rivera-Campillo ME, et al. Cutaneous, genital and oral lichen planus: a descriptive study of 274 patients. Med Oral Patol Oral Cir Bucal. 2019;24(1):e1–e7. doi: 10.4317/medoral.22656
  18. Cerqueira JDM, Moura JR, Arsati F, et al. Psychological disorders and oral lichen planus: a systematic review. J Investig Clin Dent. 2018;(4):e12363. doi: 10.1111/jicd.12363
  19. Schmidt-Westhausen AM. Oral lichen planus and lichenoid lesions: what’s new? Quintessence Int. 2020;51(2):156–161. doi: 10.3290/j.qi.a43868
  20. Liao H, Luo Y, Long L, et al. Anxiety and oral lichen planus. Oral Dis. 2021;27(3):506–514. doi: 10.1111/odi.13569
  21. Gerasimova LP, Chemikosova TS, Vildanov MN. State of anxiety in patients with keratoses of the oral mucosa. In: Topical issues of dentistry: materials of the republican conference of dentists; Ufa, October 21–23, 2014. Ufa; 2014. P:47–48. (In Russ).
  22. Manczyk B, Gołda J, Biniak A, et al. Evaluation of depression, anxiety and stress levels in patients with oral lichen planus. J Oral Sci. 2019;61(3):391–397. doi: 10.2334/josnusd.18-0113
  23. Starikova IV, Piterskaya NV, Chaplieva EM, Bobrov DS. Psychosomatic aspects of diseases of the oral mucosa. Bulletin of the Volgograd State Medical University. 2021;(2):137–140. (In Russ). doi: 10.19163/1994-9480-2021-2(78)-137-140
  24. Shaw H, Konidena A, Malhotra A, et al. Psychological status and uric acid levels in oral lichen planus patients — A case-control study. Indian J Dent Res. 2020;31(3):368–375. doi: 10.4103/ijdr.IJDR_289_19
  25. Nosratzehi T. Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments. Asian Pac J Cancer Prev. 2018;19(5):1161–1167. doi: 10.22034/APJCP.2018.19.5.1161
  26. Vilar-Villanueva M, Gándara-Vila P, Blanco-Aguilera E, et al. Psychological disorders and quality of life in oral lichen planus patients and a control group. Oral Dis. 2019;25(6):1645–1651. doi: 10.1111/odi.13106
  27. Parlatescu I, Tovaru M, Nicolae CL, et al. Oral health-related quality of life in different clinical forms of oral lichen planus. Clin Oral Investig. 2020;24(1):301–308. doi: 10.1007/s00784-019-02951-8
  28. Orekhova LYu, Osipova MV, Ladyko AA Model of development, prevention and treatment of lichen planus of the oral mucosa. Part I. Periodontology. 2018;23(4):44–47. (In Russ). doi: 10.25636/PMP.1.2018.4.8
  29. Orekhova LYu, Osipova MV, Ladyko AA. Model of development, prevention and treatment of lichen planus of the oral mucosa. Part II. Periodontology. 2019;24(1):57–62. (In Russ). doi: 10.25636/PMP.1.2019.1.10
  30. Rotaru D, Chisnoiu R, Picos AM, et al. Treatment trends in oral lichen planus and oral lichenoid lesions (Review). Exp Ther Med. 2020;20(6):198. doi: 10.3892/etm.2020.9328
  31. Beck AT, Ward CH, Mendelson M, et al. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–571. doi: 10.1001/archpsyc.1961.01710120031004
  32. Certificate of state registration of the computer program RU 2020663698/ 30.10.2020. Vildanov MN. ConScale. Available from: (In Russ).

Supplementary files

Supplementary Files
1. Fig. 1. Console program interface

Download (115KB)
2. Fig. 2. Results of testing of patients with lichen planus and the control group according to the BAI, BDI scales (Prism v.8.01 — GraphPad)

Download (151KB)

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: 015648 от 14.05.1999 г
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80635 от 15.03.2021 г

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