Current views on treatment of halitosis: foreign practice

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Traditional halitosis treatment involves reducing microbial contamination through chemical and/or mechanical action; however, these methods are ineffective in the long-term.

According to recent systematic reviews, there is no scientific evidence of the effectiveness of halitosis treatments, and even when reports indicate a positive effect, it is temporary. To increase the number of studies being compared, analysis of the results of randomized controlled trials (RCTs) should be performed considering already published data. Therefore, a review of recent RCTs is required for conducting and planning further scientific research on halitosis treatment.

Purpose of the investigation — to study the effectiveness of oral halitosis treatment based on materials from foreign publications from 2019 to 2023.

This article provides a descriptive review of foreign scientific publications on modern methods of treating oral halitosis. A search for full-text articles was conducted in the electronic databases PubMed and Google Scholar for 2019–2023. The most relevant articles that met the selection criteria were selected and included in this review: 31 publications on oral halitosis treatment: 3 Cochrane reviews of RCTs; 14 literature reviews, including meta-analyses; 12 RCTs and clinical studies; and 2 experimental studies.

In foreign studies, the use of probiotics and photodynamic therapy and their combination with standard treatment methods are most widely presented; RCTs have established their effectiveness, especially when used together with traditional methods of mechanical tongue cleaning. To prevent halitosis, it appears relevant to use materials with antibacterial properties in prosthetics, particularly the modification of polymethyl methacrylate with silver and graphene nanoparticles.

However, against the backdrop of positive results obtained in individual reviews, the conclusions of systematic reviews are contradictory. There is no evidence of the long-term effectiveness of the proposed treatment methods, and there is a weak evidence base for studies, which makes it challenging to use them in the practical work of dentists. In this regard, new RCTs with a longer observation period and considering published data are required.

Full Text

Restricted Access

About the authors

Olga S. Donskaya

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: olia.kafedra.psz@yandex.ru
ORCID iD: 0000-0002-3477-2987
SPIN-code: 1713-9441

MD, Cand. Sci. (Medicine)

Russian Federation, 6-8 L’va Tolstogo street,197022 Saint Petersburg

Ekaterina I. Berdnikova

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: berdnikova.ekaterina.81@mail.ru
ORCID iD: 0009-0006-1842-0320
SPIN-code: 3111-4682

MD, Cand. Sci. (Medicine)

Russian Federation, 6-8 L’va Tolstogo street,197022 Saint Petersburg

Vera A. Osipova

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: veraosipova@mail.ru
ORCID iD: 0000-0002-1989-5460
SPIN-code: 3133-9430

MD, Cand. Sci. (Medicine)

Russian Federation, 6-8 L’va Tolstogo street,197022 Saint Petersburg

Taras M. Markvashev

Academician I.P. Pavlov First St. Petersburg State Medical University

Author for correspondence.
Email: tarasamarkk@gmail.com
ORCID iD: 0000-0002-7729-0064
SPIN-code: 2880-8290
Russian Federation, 6-8 L’va Tolstogo street,197022 Saint Petersburg

References

  1. Renvert S, Noack MJ, Lequart C, et al. The underestimated problem of intra-oral halitosis in dental practice: an expert consensus review. Clin Cosmet Investig Dent. 2020;12:251–262. doi: 10.2147/CCIDE.S253765
  2. Hampelska K, Jaworska MM, Babalska ZŁ, Karpiński TM. The role of oral microbiota in intra-oral halitosis. J Clin Med. 2020;9(8):2484. doi: 10.3390/jcm9082484
  3. Aydin M, Derici MÇ, Keskek SO, et al. Instant and freshness effect of mouth rinses on type 1 (oral) halitosis. Efecto anti-halitosis instantáneo y efecto de frescura de los enjuagues bucales sobre la halitosis (oral) tipo I. Acta Odontol Latinoam. 2019;32(2):79–87.
  4. Gonçalves ACS, Martins MCN, Paula BL, et al. A new technique for tongue brushing and halitosis reduction: the X technique. J Appl Oral Sci. 2019;27:e20180331. doi: 10.1590/1678-7757-2018-0331
  5. Srikumar KP, Bhagyashree BN, Srirangarajan S, et al. Efficacy of Melaleuca alternifolia and chlorhexidine mouth rinses in reducing oral malodor and Solobacterium moorei levels. A 1 week, randomized, double-blind, parallel study. Indian J Pharmacol. 2022;54(2):77–83. doi: 10.4103/ijp.ijp_772_20
  6. Mogilnicka I, Bogucki P, Ufnal M. Microbiota and malodor-etiology and management. Int J Mol Sci. 2020;21(8):2886. doi: 10.3390/ijms21082886
  7. Kumbargere Nagraj S, Eachempati P, Uma E, et al. Interventions for managing halitosis. Cochrane Database Syst Rev. 2019;12(12):CD012213. doi: 10.1002/14651858.CD012213.pub2
  8. Izidoro C, Botelho J, Machado V, et al. Revisiting standard and novel therapeutic approaches in halitosis: a review. Int J Environ Res Public Health. 2022;19(18):11303. doi: 10.3390/ijerph191811303
  9. Khounganian RM, Alasmari ON, Aldosari MM, Alghanemi NM. Causes and management of halitosis: a narrative review. Cureus. 2023;15(8):e43742. doi: 10.7759/cureus.43742
  10. Bustamante M, Oomah BD, Mosi-Roa Y, et al. Probiotics as an adjunct therapy for the treatment of halitosis, dental caries and periodontitis. Probiotics Antimicrob Proteins. 2020;12(2):325–334. doi: 10.1007/s12602-019-9521-4
  11. Huang N, Li J, Qiao X, et al. Efficacy of probiotics in the management of halitosis: a systematic review and meta-analysis. BMJ Open. 2022;12(12):e060753. doi: 10.1136/bmjopen-2022-060753
  12. Jo JK, Seo SH, Park SE, et al. Identification of salivary microorganisms and metabolites associated with halitosis. Metabolites. 2021;11(6):362. doi: 10.3390/metabo11060362
  13. Karbalaei M, Keikha M, Kobyliak NM, et al. Alleviation of halitosis by use of probiotics and their protective mechanisms in the oral cavity. New Microbes New Infect. 2021;42:100887. doi: 10.1016/j.nmni.2021.100887
  14. Lowe H, Toyang N, Steele B, et al. The current and potential application of medicinal cannabis products in dentistry. Dent J (Basel). 2021;9(9):106. doi: 10.3390/dj9090106
  15. Motta PB, Motta LJ, Campos TM, et al. Effect of photodynamic therapy on halitosis: a systematic review of randomized controlled trials. Sensors (Basel). 2022;22(2):469. doi: 10.3390/s22020469
  16. Szalai E, Tajti P, Szabó B, et al. Daily use of chlorine dioxide effectively treats halitosis: a meta-analysis of randomised controlled trials. PLoS One. 2023;18(1):e0280377. doi: 10.1371/journal.pone.0280377
  17. Tay JRH, Ng E, Lai CWM, et al. The efficacy of probiotics in the management of intra-oral halitosis:a systematic review. Clin Oral Investig. 2022;26(7):4687–4700. doi: 10.1007/s00784-022-04522-w
  18. Woźniak A, Matys J, Grzech-Leśniak K. Effectiveness of lasers and aPDT in elimination of intraoral halitosis: a systematic review based on clinical trials. Lasers Med Sci. 2022;37(9):3403–3411. doi: 10.1007/s10103-022-03656-3
  19. Wylleman A, Vuylsteke F, Dekeyser C, et al. Alternative therapies in controlling oral malodour: a systematic review. J Breath Res. 2021;15(2):10.1088/1752-7163/abcd2b. doi: 10.1088/1752-7163/abcd2b
  20. Yoo JI, Shin IS, Jeon JG, et al. The effect of probiotics on halitosis: a systematic review and meta-analysis. Probiotics Antimicrob Proteins. 2019;11(1):150–157. doi: 10.1007/s12602-017-9351-1
  21. Alshahrani AA, Alhaizaey A, Kamran MA, Alshahrani I. Efficacy of antimicrobial photodynamic therapy against halitosis in adolescent patients undergoing orthodontic treatment. Photodiagnosis Photodyn Ther. 2020;32:102019. doi: 10.1016/j.pdpdt.2020.102019
  22. Benic GZ, Farella M, Morgan XC, et al. Oral probiotics reduce halitosis in patients wearing orthodontic braces: a randomized, triple-blind, placebo-controlled trial. J Breath Res. 2019;13(3):036010. doi: 10.1088/1752-7163/ab1c81
  23. da Mota ACC, Gonçalves MLL, Horliana ACRT, et al. Effect of antimicrobial photodynamic therapy with red led and methylene blue on the reduction of halitosis: controlled microbiological clinical trial. Lasers Med Sci. 2022;37(2):877–886. doi: 10.1007/s10103-021-03325-x
  24. Gurpinar B, Yildirim G, Kumral TL, et al. A simple method to reduce halitosis; tongue scraping with probiotics. J Breath Res. 2019;14(1):016008. doi: 10.1088/1752-7163/ab503e
  25. Han HS, Yum H, Cho YD, Kim S. Improvement of halitosis by probiotic bacterium Weissella cibaria CMU: a randomized controlled trial. Front Microbiol. 2023;14:1108762. doi: 10.3389/fmicb.2023.1108762
  26. Labban N, Assery MK, Al-Kattan R, et al. Antimicrobial capacity of photodynamic therapy on oral health-related quality of life and halitosis among elderly patients wearing removal dentures. Photodiagnosis Photodyn Ther. 2020;32:102059. doi: 10.1016/j.pdpdt.2020.102059
  27. Lee DS, Kim M, Nam SH, et al. Effects of oral probiotics on subjective halitosis, oral health, and psychosocial health of college students: a randomized, double-blind, placebo-controlled study. Int J Environ Res Public Health. 2021;18(3):1143. doi: 10.3390/ijerph18031143
  28. Matsumura Y, Hinode D, Fukui M, et al. Effectiveness of an oral care tablet containing kiwifruit powder in reducing oral bacteria in tongue coating: a crossover trial. Clin Exp Dent Res. 2020;6(2):197–206. doi: 10.1002/cre2.262
  29. Llanos do Vale K, Ratto Tempestini Horliana AC, Romero Dos Santos S, et al. Treatment of halitosis with photodynamic therapy in older adults with complete dentures: a randomized, controlled, clinical trial. Photodiagnosis Photodyn Ther. 2021;33:102128. doi: 10.1016/j.pdpdt.2020.102128
  30. Bacali C, Carpa R, Buduru S, et al. Association of graphene silver polymethyl methacrylate (PMMA) with photodynamic therapy for inactivation of halitosis responsible bacteria in denture wearers. Nanomaterials (Basel). 2021;11(7):1643. doi: 10.3390/nano11071643
  31. Yoo HJ, Jwa SK, Kim DH, Ji YJ. Inhibitory effect of Streptococcus salivarius K12 and M18 on halitosis in vitro. Clin Exp Dent Res. 2020;6(2):207–214. doi: 10.1002/cre2.269
  32. Pavlova SS, Korneenkov AA, Dvorianchikov VV, et al. Assessment of population health losses due to nasal obstruction based on the concept of the global burden of disease: general approaches and research directions. Medical Council. 2021;(12):138–145. EDN: TRFQNY doi: 10.21518/2079-701X-2021-12-138-145
  33. Kadyrov ZA, Faniev MV, Prokopiev YaV, et al. Reproductive health of the russian population as a key factor of demographic dynamics. The Bulletin of Contemporary Clinical Medicine. 2022;15(5):100–106. EDN: FPJIAU doi: 10.20969/VSKM.2022.15(5).100-106
  34. Povarov JuV, Dvorjanchikov VV. Rational antibiotic therapy in the treatment of acute and chronic sinusitis. Russian Rhinology. 1994;(2):49. (In Russ). EDN: IBQODL
  35. Sevryukov F, Malinina O. New organizational schemes of providing medical care to patients with benign hyperplasia of the prostate gland. Social Aspects of Population Health. 2012;(1):5. EDN: OVYASH
  36. Starcev VJu, Dudarev VA, Sevrjukov FA, Zabrodina NB. Economic aspects of treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia. Urologiia. 2019;(6):115–119. EDN: DBIZTQ doi: 10.18565/urology.2019.6.115-119
  37. Sevryukov FA, Kamaev IA, Grib MN, et al. Risk factors and quality of life in patients with benign prostatic hyperplasia. I.P. Pavlov Russian Medical Biological Herald. 2011;19(3):48–52. EDN: OYKKID
  38. Donskaja OS. Prognostic value of oral fluid features of dental patients with biomineralopathies [dissertation]. Saint Petersburg, 2017. (In Russ). EDN: YFZYWO
  39. Kryukov EV, Zhdanov KV, Kozlov KV, et al. Electron microscopic changes in the nasal membrane of patients with covid-19 depending on the clinical form and the period of the disease. Jurnal Infektologii. 2021;13(2):5–13. EDN: UYWDWK doi: 10.22625/2072-6732-2021-13-2-5-13
  40. Kokorina OV, Kasatkin AN, Dvorjanchikov VV. the regenerative specificity of surgical wounds after tonsillectomia with chitosan implementation. Bulletin of the Russian Military Medical Academy. 2017;(2):13–18. EDN: ZAOOBF
  41. Apolikhin OI, Sevrukov FA, Sorokin DA, et al. State and prognosis of the urogenital diseases morbidity in the adults of Nizhegorodsky region. Experimental & Clinical Urology. 2012;(4):4–7. EDN: PLNQQD
  42. Govorun MI, Dvoryanchikov VV, Tsygan LS. Functional recovery of nose and pharyngeal opening of auditory tube in simultaneous rhinootosurgery. Bulletin of the Russian Military Medical Academy. 2009;(4):112–115. EDN: KYKNDJ
  43. Dvoryanchikov VV, Grebnev GA, Balin VV, Shafigullin AV. Complex treatment of odontogenic maxillary sinusitis. Clinical Dentistry (Russia). 2019;(2):65–67. EDN: SEBCAP doi: 10.37988/1811-153X_2019_2_65
  44. Ovchinnikov AYu, Panin AM, Mustafadze KN. Simultaneous vs two-stage surgery for chronic rhinosinusitis and secondary maxillary adentia according to SNOT-22 and HADS questionnaires. Rossijskaja otorinolaringologija. 2022;(1):42–50. EDN: GEZUWS doi: 10.18692/1810-4800-2022-1-42-50
  45. Dvoryanchikov VV, Grebnev GA, Isachenko VS, Shafigullin AV. Odontogenic maxillary sinusitis: current state of the problem. Bulletin of the Russian Military Medical Academy. 2018;(4):169–173. EDN: YOIRQL

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1. Algorithm for selecting publications.

Download (321KB)

Copyright (c) 2023 Eco-Vector

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 86295 от 11.12.2023 г
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80635 от 15.03.2021 г
.



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies