Mitochondrial dysfunction in the pathogenesis and treatment of oral inflammatory diseases

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Oral inflammatory diseases (OIDs) include various prevalent conditions, such as periodontal disease and pulpitis. The most common causes of OIDs are microorganisms, injuries, occlusion factors, autoimmune diseases, and radiation therapy. If not treated properly, these diseases not only affect the oral health, but may also compromise the overall well-being. Thus, early detection of OIDs and new treatment strategies are key challenges of oral therapy research.

Mitochondria are essential organelles for numerous cellular processes. Mitochondrial dysfunction not only affects cell metabolism, but also has an indirect impact on health and life expectancy. Several common polygenic diseases, such as cardiovascular and neurodegenerative disorders, are associated with mitochondrial dysfunction. Recent evidence suggests that mitochondrial dysfunction plays a significant role in the development and progression of OIDs and associated systemic diseases.

This review provides critical insights into mitochondrial dysfunction and its role in inflammatory reactions in OIDs.

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作者简介

Albina Abdullaeva

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

编辑信件的主要联系方式.
Email: albi.95@mail.ru
ORCID iD: 0009-0002-0538-7454
SPIN 代码: 4355-9186
俄罗斯联邦, 46 Zhivopisnaya street, 123098 Moscow

Valentina Olesova

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Email: olesova@implantat.ru
ORCID iD: 0000-0002-3461-9317
SPIN 代码: 6851-5618

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, 46 Zhivopisnaya street, 123098 Moscow

David Akopov

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Email: akopov.85@bk.ru
ORCID iD: 0009-0000-0603-9406
俄罗斯联邦, 46 Zhivopisnaya street, 123098 Moscow

Egor Olesov

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Email: olesov_georgiy@mail.ru
ORCID iD: 0000-0001-9165-2554
SPIN 代码: 8924-3520

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, 46 Zhivopisnaya street, 123098 Moscow

Serazhutdin Abdullaev

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Email: saabdullaev@gmail.com
ORCID iD: 0000-0002-1396-0743
SPIN 代码: 3485-8990

Dr. Sci. (Biology)

俄罗斯联邦, 46 Zhivopisnaya street, 123098 Moscow

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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