Diseases of the oral mucosa associated with Helicobacter pylori

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Abstract


This study analyzed the role of Helicobacter pylori in the development of lesions of the oral mucosa and explored the relationship between the prevalence and intensity of periodontal disease and the stage, duration, and severity of gastrointestinal diseases associated with H. pylori infection. The newly identified factors of H. pylori pathogenicity that participate in the development of lesions of the oral mucosa in case of a body infection were also determined.


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About the authors

Svetlana V. Tarasenko

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Author for correspondence.
Email: prof_Tarasenko@rambler.ru

Russian Federation, Moscow

MD, Dr. Sci. (Med.), Professor

M. A. Stepanov

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: prof_Tarasenko@rambler.ru

Russian Federation, Moscow

S. A. Kalinin

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: prof_Tarasenko@rambler.ru

Russian Federation, Moscow

V. V. Morozova

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: prof_Tarasenko@rambler.ru

Russian Federation, Moscow

References

  1. Gabibov RS, Dadamov RA, Akhmedov TS. The problems pertaining to the prevalence, pathogenesis, diagnostics, and treatment of chronic gastritis and ulcer disease associated with Helicobacter pylori infection. Dokazatelnaya gastroenterologiya. 2017;6(4):20–24. doi: 10.17116/dokgastro20176420-24. (in Russian).
  2. Maksimovskaya LN, Abramova MY, Erk AA. Implementation of the national program of cancer screening of oral precancerous and oncological diseases in the Russian Federation. Stomatologiya (Mosk). 2019;98(4):44. doi: 10.17116/stomat20199804144. (in Russian).
  3. Gel’fand IM, Romanov IS, Udintsov DB. Treatment policy for localized oral cancer. Opukholi golovy i shei. 2016;6(1):43–45. doi: 10.17650/2222-1468-2016-6-1-43-45. (in Russian).
  4. Bogatu SI. Combined pathology: periodontal and gastroduodenal diseases. Innovatsii v stomatologii. 2017;(3-4):40–46. (in Russian).
  5. Kosyuga SY Ashkinazi VI, Varvanina SE. The state of local immunity of the oral cavity in persons with diseases of mucous membrane and the different degree of colonization of the stomach by Helicobacter pylori before and after treatment. Kubanskii nauchnyi meditsinskii vestnik. 2016;(4):63–67. doi: 10.25207/1608-6228-2016-4-63-67. (in Russian).
  6. Yee JKC. Are the view of Helicobacter pylori colonized in the oral cavity an illusion? Exp Mol Med. 2017;49(11):e397. doi: 10.1038/emm.2017.225.
  7. Bogacheva NV, Tuneva NA, Kolevatykh EP, Zaitseva IV. The study of microbial Association of periodontal pockets in patients with Helicobacter pylori infection. Vyatskii meditsinskii vestnik. 2018;3(59):85–89. (in Russian).
  8. Mendoza-Cantu A, Urrutia-Baca VH, Urbina-Rios CS, et al. Prevalence of Helicobacter pylori vacA Genotypes and cagA Gene in Dental Plaque of Asymptomatic Mexican Children. Biomed Res Int. 2017;2017:4923640. doi: 10.1155/2017/4923640.
  9. Chobanov RE, Mamedov RM. Periodontal pockets as biotopes of accumulation and vital activity of Helicobacter pylori. Sibirskii meditsinskii zhurnal. 2008;(7):72–73. (in Russian).
  10. Lauritano D, Cura F, Candotto V, et al. Periodontal Pockets as a Reservoir of Helicobacter Pylori Causing Relapse of Gastric Ulcer: A Review of the Literature. J Biol Regul Homeost Agents. 2015;29(3S1):123–126.
  11. Moseeva MV, Khitrov VY, Belova EV. Helicobacter pylori in the light of pathogenesis of interorgan at gastroenterological diseases. Prakticheskaya meditsina. 2011;(1):79–82. (In Russ).
  12. Lundmark A, Johannsen G, Eriksson K, et al. Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis. J Clin Periodontol. 2017;44(3):247–254. doi: 10.1111/jcpe.12670.
  13. Ryabokon' EN, Sokolova II, Oleinichuk VV. Pathomorphological changes in the epithelium of periodontal pockets in patients with generalized periodontitis combined with peptic ulcer disease. Visnyk problem biolohii i medytsyny. 2013;1(4):342–346. (In Russ).
  14. Meng X, Wang Q, He C, et al. An inverse association of Helicobacter pylori infection with oral squamous cell carcinoma. J Oral Pathol Med. 2016;45(1):17–22. doi: 10.1111/jop.12324.
  15. Kazanowska-Dygdala M, Dus I, Radwan-Oczko M. The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus. J Appl Oral Sci. 2016;24(1):18–23. doi: 10.1590/1678-775720150203.
  16. Zheng P, Zhou W. Relation between periodontitis and helicobacter pylori infection. Int J Clin Exp Med. 2015;8(9):16741–16744. 4659103.
  17. Hu Z, Zhang Y, Li Z, et al. Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation. Oncotarget. 2016;7(41):66700-66712. doi: 10.18632/oncotarget.11449.
  18. Lee AY, Kao CY, Wang YK, et al. Inactivation of ferric uptake regulator (Fur) attenuates Helicobacter pylori J99 motility by disturbing the flagellar motor switch and autoinducer-2 production. Helicobacter. 2017;22(4). doi: 10.1111/hel.12388.
  19. Talebi Bezmin Abadi A, Taghvaei T, Mohabbati Mobarez A, et al. High correlation of babA 2-positive strains of Helicobacter pylori with the presence of gastric cancer. Intern Emerg Med. 2013;8(6):497–501. doi: 10.1007/s11739-011-0631-6.
  20. Benktander J, Barone A, Johansson MM, Teneberg S. Helicobacter pylori SabA binding gangliosides of human stomach. Virulence. 2018;9(1):738–751. doi: 10.1080/21505594.2018.1440171.
  21. Kao CY, Sheu BS, Wu JJ. Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis. Biomed J. 2016;39(1):14–23. doi: 10.1016/j.bj.2015.06.002.
  22. Graham DY, Miftahussurur M. Helicobacter pylori urease for diagnosis of Helicobacter pylori infection: A mini review. J Adv Res. 2018;13:51–57. doi: 10.1016/j.jare.2018.01.006.
  23. Nakano M, Yahiro K, Yamasaki E, et al. Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase alpha, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521. Dis Model Mech. 2016;9(12):1473–1481. doi: 10.1242/dmm.025361.
  24. Pozdeev OK, Pozdeeva AO, Valeeva YV, et al. Mechanisms of interacting Helicobacter pylori with gastric mucosal epithelium. II. A reaction of gastric epithelium on Helicobacter pylori colonization and persistence. Infektsiyai immunitet. 2019;9(2):253–261. doi: 10.15789/2220-7619-2019-2-253-261. (in Russian).
  25. Pozdeev ОК, Pozdeeva АО, Valeeva YV, Gulyaev PE. Mechanisms of Interraction of Helicobacter Pylori with Epithelium of Gastric Mucosa. I. Pathogenic Factors Promoting Successful Colonization. Infektsiya i immunitet. 2018;8(3):273–283. doi: 10.15789/2220-7619-2018-3-273-283. (in Russian).
  26. Matveeva LV, Kapkaeva RKh, Chudaikin AN, Mishanina LS. Changes of the serum levels of tumor necrosis factor-α at diseases gastric. Eksperimentalnaya i klinicheskaya gastroenterojgiyal. 2018;(3):53–57. (in Russian).
  27. Tsyganova MI, Talaeva MV, Talaev VY, et al. Influence exerted by Helicobacter pylori on concentrations of anti-inflammatory Т-cell cytokines and sunpopulations that produce them. Analiz riska zdorov’yu. 2018;(3):120–127. doi: 10.21668/health. risk/2018.3.13. (in Russian).
  28. Boonyanugomol W, Chomvarin C, Hahnvajanawong C, et al. Helicobacter pylori cag pathogenicity island (cagPAI) involved in bacterial internalization and IL-8 induced responses via NOD1- and MyD88-dependent mechanisms in human biliary epithelial cells. PLoS One. 2013;8(10):e77358. doi: 10.1371/journal.pone.0077358.
  29. Kikuchi K, Murata-Kamiya N, Kondo S, Hatakeyama M. Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling. Microbes Infect. 2012;14(5):470-476. doi: 10.1016/j.micinf.2011.12.003.
  30. Zhong Y, Anderl F, Kruse T, et al. Helicobacter pylori HP0231 Influences Bacterial Virulence and Is Essential for Gastric Colonization. PLoS One. 2016;11(5):e0154643. doi: 10.1371/journal.pone.0154643.
  31. Jang S, Su H, Blum FC, et al. Dynamic Expansion and Contraction of cagA Copy Number in Helicobacter pylori Impact Development of Gastric Disease. mBio. 2017;8(1). doi: 10.1128/mBio.01779-16.
  32. Isaeva GSh, Valieva RI. Biological characteristics and virulence of Helicobacter pylori. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2018;20(1):14-20. (in Russian).

Supplementary files

Supplementary Files Action
1.
Biopsy material of periodontal pockets in peptic ulcer disease associated with H. pylori [13].

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