Study of the influence of different methods of application of Metrogyl Denta gel on the microbiota of periodontal pockets in periodontitis

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Abstract

BACKGROUND: One of the most popular antibacterial drugs used in periodontology is Metrogil Denta gel. In recent years, it is most often prescribed as a means of local antibacterial therapy. However, there is practically no information about the use of Metrogil Denta gel ultraphonophoresis in the treatment of periodontal tissue diseases. Therefore, the development of the Metrogil Denta gel ultraphonophoresis technique and the study of its effectiveness in inflammatory periodontal diseases has significant theoretical and practical interest.

AIM: This study aimed to explore the influence of various methods of using Metrogyl Denta gel on the microbiota of the periodontal pockets in periodontitis.

MATERIALS AND METHODS: In the first group (main), composed of 20 patients with a diagnosis of moderate periodontitis, the treatment procedures included high-frequency ultrasound and application of antibacterial preparation of Metrogyl Denta gel for the periodontal tissue (ultraphonophoresis of Metrogyl Denta gel). In the second group (control), composed of 20 patients with a diagnosis of moderate periodontitis, phonophoresis was not prescribed, and Metrogyl Denta gel was applied into the surface of the gums of the upper and lower jaw two times a day for 10 days.

RESULTS: Contents of the pathological periodontal pockets were examined twice: first after dental plaque removal in patients with periodontitis of the main and control groups and then after 10 ultraphonophoresis procedures using Metrogyl Denta gel as a contact medium in the study group or after 10 days of Metrogyl Denta gel applications in the control group. Data analysis revealed that ultraphonophoresis of Metrogyl Denta gel has a more pronounced antibacterial effect in comparison with the injection of this drug.

CONCLUSIONS: The combined effect of high-frequency ultrasound and Metrogyl Denta gel makes it possible to create a drug reserve in the periodontal tissues.

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About the authors

Dmitry I. Morozov

Burnazyan Federal Medical Biophisical Center

Email: info@stomatologclub.ru
Russian Federation, Moscow

Alexander G. Volkov

I.M. Sechenov First Moscow State Medical University Moscow (Sechenov University)

Email: parodont@inbox.ru
ORCID iD: 0000-0003-2674-1942

MD, Dr. Sci. (Med.), Professor

Russian Federation, 2, Bolshaya Pirogovskaya str., 119991, Moscow

Egor E. Olesov

Burnazyan Federal Medical Biophisical Center

Email: olesov_georgiy@mail.ru

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Nataliya Zh. Dikopova

I.M. Sechenov First Moscow State Medical University Moscow (Sechenov University)

Author for correspondence.
Email: zubnoy-doctor@yandex.ru
ORCID iD: 0000-0002-4031-2004

MD, Cand. Sci. (Med.), assistant professor

Russian Federation, 2, Bolshaya Pirogovskaya str., 119991, Moscow

Yulia A. Trefilova

A.I. Evdokimov Moscow State Medical and Dental University

Email: zubnoy-doctor@yandex.ru
ORCID iD: 0000-0002-0443-4071
Russian Federation, Moscow

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