电邮这篇文章 Chronic periodontitis and ischemic heart disease: morphofunctional relation-ships
- 作者: Eremin A.V.1, Lepilin A.V.1, Lipatova T.E.1, Kvetnoy I.M.2,3
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隶属关系:
- Saratov State Medical University named аfter V.I. Razumovsky, Ministry of Health of Russia
- D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
- Saint Petersburg State University
- 期: 卷 24, 编号 4 (2020)
- 页面: 219-224
- 栏目: Clinical Investigation
- ##submission.dateSubmitted##: 14.12.2020
- ##submission.dateAccepted##: 14.12.2020
- ##submission.datePublished##: 15.08.2020
- URL: https://rjdentistry.com/1728-2802/article/view/55139
- DOI: https://doi.org/10.17816/1728-2802-2020-24-4-219-224
- ID: 55139
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详细
The relationship between periodontal diseases and cardiovascular pathology is actively being studied. The clinical significance of tissue markers of endothelial dysfunction in acute or chronic periodontitis needs to be clarified.
Materials and methods. The results of the examination of 65 patients with chronic generalized periodontitis (CP), 35 patients with chronic coronary heart disease (CHD), and 35 patients with combined pathology including CHD and CP were presented. Clinical instrumental examination, assessment of the functional state of the endothelium, immunohistochemical, and morphometric studies were performed.
Results. Patients with moderate CP were characterized by functional changes in the endothelium, decreased expression of the vasodilating factor (e-NO-synthase), and endothelial progenitor cells (CD34+cells) in the vascular wall. In patients with CHD without periodontitis, there was also a decrease in the expression and optical density of endothelial NO-synthase and endothelial progenitor cell in the periodontal vessels.
Conclusion. Apparently, changes in the expression of endothelial NO-synthase and endothelial progenitor cells (CD34+cells) in the vascular wall are generalized, and the gum can serve as a promising material for the early assessment of endothelial dysfunction.
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作者简介
Andrey Eremin
Saratov State Medical University named аfter V.I. Razumovsky, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: ereminandrei@rambler.ru
PhD, First Vice-Rector Saratov State Medical University n.a. V.I. Razumovsky
俄罗斯联邦, 410012, SaratovA. Lepilin
Saratov State Medical University named аfter V.I. Razumovsky, Ministry of Health of Russia
Email: ereminandrei@rambler.ru
俄罗斯联邦, 410012, Saratov
T. Lipatova
Saratov State Medical University named аfter V.I. Razumovsky, Ministry of Health of Russia
Email: ereminandrei@rambler.ru
俄罗斯联邦, 410012, Saratov
I. Kvetnoy
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology; Saint Petersburg State University
Email: ereminandrei@rambler.ru
俄罗斯联邦, 199034, Saint Petersburg; 199034, Saint Petersburg
参考
- Eremin AV, Lipatova TE, Lepilin AV, Eremin VI. Assessment of cardiovascular risk factors in patients with chronic periodontitis. Saratovskii nauchno-meditsinskii zhurnal. 2020;16(1):45–9. (in Russian)
- Dietrich T, Sharma P, Weston P, Beck J. The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease. J. Periodontol. 2013;84(4 Suppl):70–84. doi: 10.1902/jop.2013.134008.
- Pimenova MP, Arutyunov SD. Features of the course of chronic inflammatory diseases of periodontal tissues in patients with acute myocardial in-farction. Rossiyskii stomatologicheskii zhurnal. 2014;(3):42–46. (in Russian)
- Holmlund A, Lampa E, Lind L. Oral health and cardiovascular disease risk in a cohort of periodontitis patients. Atherosclerosis. 2017;262:101–6. doi: 10.1016/j.atherosclerosis.2017.05.009.
- Schenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J. Periodontol. 2013;84(4 Suppl):51–69. doi: 10.1902/jop.2013.134006.
- Amelina IP, Solov'eva EYu. Oxidative stress and inflammation as links in the same chain in patients with chronic cerebrovascular diseases. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2019;119(4):106–14. (in Russian). doi: 10.17116/jnevro2019119041106.
- Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation. 2007;115(10): 1285–95. doi: 10.1161/CIRCULATIONAHA.106.652859.
- Stepanova TV, Ivanov AN, Tereshkina NE, Popykhova EB, Lagutina DD. Markers of endothelial dysfunction: pathogenetic role and diagnostic sig-nificance (literature review). Klinicheskaya laboratornaya diagnostika. 2019;(1):34–41. (in Russian)
- Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N. Engl. J. Med. 2003;348(7):593–600. doi: 10.1056/NEJMoa022287.
- Plein A, Fantin A, Denti L, Pollard JW, Ruhrberg C. Erythro-myeloid progenitors contribute endothelial cells to blood vessels. Nature. 2018;562(7726):223–8. doi: 10.1038/s41586-018-0552-x.
- Hirschi KK, Ingram DA, Yoder MC. Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler. Thromb. Vase Biol. 2008;28(9):1548–95. doi: 10.1161/ATVBAHA.107.155960.
- Belova YuA, Chuksina YuYu, Shevelev SV, Yazdovskiy VV, Kotov SV. The level of endothelial progenitor cells in patients with ischemic stroke and the effectiveness of rehabilitation. Al'manakh klinicheskoi meditsiny. 2015;(39):45–50. (in Russian)
- Werner N, Wassmann S, Ahlers P, Schiegl T, Kosiol S., et al. Endothelial progenitor cells correlate with endothelial function in patients with coro-nary artery disease. Basic Res. Cardiol. 2007;102(6):565–71. doi: 10.1007/s00395-007-0680-1.
- Li X, Tse HF, Yiu KH, Jia N, Chen H, Sheung Wai Li L, Jin L. Increased levels of circulating endothelial progenitor cells in subjects with moderate to severe chronic periodontitis. J. Clin. Periodontol. 2009;36(11):933–9. doi: 10.1111/j.1600-051X.2009.01481.x.
- Gurav AN. The implication of periodontitis in vascular endothelial dysfunction. Eur. J. Clin. Investig. 2014;44(10):1000–9. doi: 10.1111/eci.12322.
- Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D'Aiuto F, Bouchard P, et al. Periodontitis and cardiovascular diseases. Consensus report. J. Clin. Periodontol. 2020;47(3):268–88. doi: 10.1111/jcpe.13189.
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