FETAL PROGRAMMING OF MOLAR-INCISOR HYPOMINERALIZATION: A SYSTEMATIC REVIEW



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Introduction

Molar incisor hypomineralization (MIH) is a type of enamel defect of the first molars and incisors in the permanent dentition affecting one in eight children worldwide. The results of the analysis s of publications on the topic of fetal MRG programming reveled the need for a more detailed study of the causes of its occurrence, depending on the influence of antenatal and perinatal factors. The data were collected from two electronic databases, PubMed and e-library.ru, using key words, inclusion- and exclusion criteria with no time limits. The selection process consisted of two stages. Initially, publications were screened based on their titles and abstracts to determine their relevance to the review. Secondly, the authors thoroughly examined the full text of the articles. Any discrepancies were resolved through group discussions among the authors until a consensus was reached. Of the initially identified 157 studies, 29 were included in the qualitative synthesis. The findings revealed several antenatal factors associated with MIH. These factors include anemia during pregnancy, complications of the third trimester, gestational diabetes, viral diseases, three ultrasound examinations in the third trimester, preeclampsia, alcohol consumption, psychological stress, etc. In addition, several intranatal factors were found to be linked to MIH. These factors include hypoxia at birth, prolonged labor, premature labor, low birth weight, labor induction, complications during childbirth, Caesarean section, etc. The current evidence suggests that a wide range of antenatal and perinatal factors are associated with MIH. High quality research with sufficient sample size and sound data analysis is warranted to strengthen the evidence that could be used for development of population-level prevention strategies.

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Aleksandra Algazina

Northern State Medical University, Arkhangelsk, Russian Federation

编辑信件的主要联系方式.
Email: algazina.sascha@ya.ru
ORCID iD: 0000-0002-3876-5960
SPIN 代码: 8363-2605

Assistant at the Department of Pediatric Dentistry

俄罗斯联邦, 163000, Россия, Архангельск, пр. Троицкий, 51.

Maria Gorbatova

Northern State Medical University

Email: marigora@mail.ru
ORCID iD: 0000-0002-6363-9595
SPIN 代码: 7732-0755

Cand. Sci. (Med.), MPH, associate professor

俄罗斯联邦, Arkhangelsk

Andrej Grjibovski

Northern State Medical University

Email: a.grjibovski@yandex.ru
ORCID iD: 0000-0002-5464-0498
SPIN 代码: 5118-0081

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦

Polina Pochinkova

Northern State Medical University

Email: miekandr@yandex.ru
ORCID iD: 0000-0002-5631-5197
SPIN 代码: 5996-4317

ассистент кафедры стоматологии детского возраста

俄罗斯联邦, 163000, Россия, Архангельск, пр. Троицкий, 51.

Lyubov Gorbatova

Northern State Medical University

Email: info@nsmu.ru
ORCID iD: 0000-0003-0675-3647
SPIN 代码: 8037-5341

Dr. Sci. (Med.), professor

俄罗斯联邦, Arkhangelsk

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