FETAL PROGRAMMING OF MOLAR-INCISOR HYPOMINERALIZATION: A SYSTEMATIC REVIEW



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Abstract

Introduction: 

Molar incisor hypomineralization (MIH) is a type of enamel defect of the first molars and incisors in the permanent dentition affecting one in eight children worldwide. The results of the analysis s of publications on the topic of fetal MRG programming reveled the need for a more detailed study of the causes of its occurrence, depending on the influence of antenatal and perinatal factors. The data were collected from two electronic databases, PubMed and e-library.ru, using key words, inclusion- and exclusion criteria with no time limits. The selection process consisted of two stages. Initially, publications were screened based on their titles and abstracts to determine their relevance to the review. Secondly, the authors thoroughly examined the full text of the articles. Any discrepancies were resolved through group discussions among the authors until a consensus was reached. Of the initially identified 157 studies, 29 were included in the qualitative synthesis. The findings revealed several antenatal factors associated with MIH. These factors include anemia during pregnancy, complications of the third trimester, gestational diabetes, viral diseases, three ultrasound examinations in the third trimester, preeclampsia, alcohol consumption, psychological stress, etc. In addition, several intranatal factors were found to be linked to MIH. These factors include hypoxia at birth, prolonged labor, premature labor, low birth weight, labor induction, complications during childbirth, Caesarean section, etc. The current evidence suggests that a wide range of antenatal and perinatal factors are associated with MIH. High quality research with sufficient sample size and sound data analysis is warranted to strengthen the evidence that could be used for development of population-level prevention strategies.

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About the authors

Aleksandra A. Algazina

Northern State Medical University, Arkhangelsk, Russian Federation

Author for correspondence.
Email: algazina.sascha@ya.ru
ORCID iD: 0000-0002-3876-5960
SPIN-code: 8363-2605

Assistant at the Department of Pediatric Dentistry

Russian Federation, 163000, Россия, Архангельск, пр. Троицкий, 51.

Maria A. Gorbatova

Northern State Medical University

Email: marigora@mail.ru
ORCID iD: 0000-0002-6363-9595
SPIN-code: 7732-0755

Cand. Sci. (Med.), MPH, associate professor

Russian Federation, Arkhangelsk

Andrej M. Grjibovski

Northern State Medical University

Email: a.grjibovski@yandex.ru
ORCID iD: 0000-0002-5464-0498
SPIN-code: 5118-0081

MD, Dr. Sci. (Med.), Professor

Russian Federation

Polina A. Pochinkova

Northern State Medical University

Email: miekandr@yandex.ru
ORCID iD: 0000-0002-5631-5197
SPIN-code: 5996-4317

ассистент кафедры стоматологии детского возраста

Russian Federation, 163000, Россия, Архангельск, пр. Троицкий, 51.

Lyubov N. Gorbatova

Northern State Medical University

Email: info@nsmu.ru
ORCID iD: 0000-0003-0675-3647
SPIN-code: 8037-5341

Dr. Sci. (Med.), professor

Russian Federation, Arkhangelsk

References

  1. Weerheijm KL, Jälevik B, Alaluusua S. Molar-incisor hypomineralisation. Caries Res. 2001 Sep-Oct;35(5):390-1. https://doi.org/10.1159/000047479
  2. Garot E, Rouas P, Somani C, Taylor GD, Wong F, Lygidakis NA. An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis. Eur Arch Paediatr Dent. 2022 Feb;23(1):23-38. https://doi.org/10.1007/s40368-021-00646-x
  3. Elhennawy K, Schwendicke F. Managing molar-incisor hypomineralization: A systematic review. J Dent. 2016 Dec; 55:16-24. https://doi.org/10.1016/j.jdent.2016.09.012.
  4. Schwendicke F, Elhennawy K, Reda S, Bekes K, Manton DJ, Krois J. Global burden of molar incisor hypomineralization. J Dent. 2018 Jan;68:10-18. https://doi.org/10.1016/j.jdent.2017.12.002
  5. Gorbatova M.A., Utkina E.I., Zinchenko G.A., Grjibovski A.M., Popova D.A., Popov V.A., Gorbatova L.N. Molar-incisor hypomineralization among 12-year old children in Arkhangelsk region // Stomatologiya. 2019;98(2):64‑66. (In Russ.) https://doi.org/10.17116/stomat20199802164
  6. Luchsheva LF, Hamadeeva AM, Rusakova EYu, Rybak OG, Alekseeva EO. Epidemiologiya molyarno-rezcovoj gipomineralizacii u detej Habarovskogo kraya. Uspekhi sovremennogo estestvoznaniya. 2015;8:26-30. (In. Russ.).
  7. Kosyreva TF, Pronyaeva AI. Klassifikaciya i rasprostranennost’ gipoplazii ehmali. Stomatologiya detskogo vozrasta i profilaktika. 2013;2:23. (In Russ.).
  8. Mandy M, Nyirenda M. Developmental Origins of Health and Disease: the relevance to developing nations. Int Health. 2018 Mar 1;10(2):66-70. https://doi.org/10.1093/inthealth/ihy006
  9. Kwon EJ, Kim YJ. What is fetal programming?: a lifetime health is under the control of in utero health. Obstet Gynecol Sci. 2017 Nov;60(6):506-519. https://doi.org/10.5468/ogs.2017.60.6.506
  10. Wadhwa PD, Buss C, Entringer S, Swanson JM. Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms. Semin Reprod Med. 2009 Sep;27(5):358-68. https://doi.org/10.1055/s-0029-1237424
  11. Kazhina M.V. Fetal programming of postnatal life // Zdravoohranenie. 2018;3;22-28. (In Russ.).
  12. Petrov Yu.A., Kupina A.D. Fetal programming is a way to prevent diseases in adulthood (literature review). Meditsinskiy sovet = Medical Council. 2020;(13):50–56. (In Russ.). https://doi.org/10.21518/2079-701X-2020-13-50-56
  13. Barker DJ. The developmental origins of adult disease. J Am Coll Nutr. 2004 Dec;23(6 Suppl):588S-595S. https://doi.org/10.1080/07315724.2004.10719428
  14. Oh DL, Jerman P, Silvério Marques S, Koita K, Purewal Boparai SK, Burke Harris N, Bucci M. Systematic review of pediatric health outcomes associated with childhood adversity. BMC Pediatr. 2018 Feb 23;18(1):83. https://doi.org/10.1186/s12887-018-1037-7
  15. Mortillo M, Marsit CJ. Select Early-Life Environmental Exposures and DNA Methylation in the Placenta. Curr Environ Health Rep. 2023 Mar;10(1):22-34. https://doi.org/10.1007/s40572-022-00385-1
  16. Perrone S, Santacroce A, Picardi A, Buonocore G. Fetal programming and early identification of newborns at high risk of free radical-mediated diseases. World J Clin Pediatr. 2016 May 8;5(2):172-81. https://doi.org/10.5409/wjcp.v5.i2.172
  17. Dzgoeva F.K. Intrauterine nutrition: fetal programming of metabolic syndrome. Obesity and metabolism. 2015;12(3):10-17. (In Russ.) https://doi.org/10.14341/omet2015310-17
  18. Pervunina T. M., Erman M. V., Moiseeva O. M. Fetal programming and hypertension. Underlying mechanisms (review) // Vestnik Sankt-Peterburgskogo universiteta. Medicina. 2014;3;5-18. (In Russ.).
  19. Lysenko G.H. Rol' neblagopriyatnyh faktorov antenatal'nogo perioda v formirovanii zubov i razvitii stomatologicheskih zabolevanij u detej // Gigiena i sanitariya. 2004; 4: 28-30(In Russ.).
  20. Silva MJ, Kilpatrick NM, Craig JM, Manton DJ, Leong P, Burgner DP, Scurrah KJ. Genetic and Early-Life Environmental Influences on Dental Caries Risk: A Twin Study. Pediatrics. 2019 May;143(5):e20183499. https://doi.org/10.1542/peds.2018-3499
  21. Lacruz RS, Habelitz S, Wright JT, Paine ML. Dental enamel formation and implications for oral health and disease. Physiol Rev. 2017;1;97(3):939-993. https://doi.org/10.1152/physrev.00030.2016
  22. Lima LJS, Ramos-Jorge ML, Soares MEC. Prenatal, perinatal and postnatal events associated with hypomineralized second primary molar: a systematic review with meta-analysis. Clin Oral Investig. 2021 Dec;25(12):6501-6516. https://doi.org/10.1007/s00784-021-04146-6
  23. Ahmadi R, Ramazani N, Nourinasab R. Molar incisor hypomineralization: a study of prevalence and etiology in a group of Iranian children. Iran J Pediatr. 2012 Jun;22(2):245-51.
  24. Arheiam A, Abbas S, Ballo L, Borowis E, Rashwan S, El Tantawi M. Prevalence, distribution, characteristics and associated factors of molar-incisor hypo-mineralization among Libyan schoolchildren: a cross-sectional survey. Eur Arch Paediatr Dent. 2021 Aug;22(4):595-601. https://doi.org/10.1007/s40368-020-00594-y
  25. Elfrink ME, Moll HA, Kiefte-de Jong JC, Jaddoe VW, Hofman A, ten Cate JM, Veerkamp JS. Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study. PLoS One. 2014 Jul 2;9(7):e91057. https://doi.org/10.1371/journal.pone.0091057
  26. Elzein R, Chouery E, Abdel-Sater F, Bacho R, Ayoub F. Molar-incisor hypomineralisation in Lebanon: association with prenatal, natal and postnatal factors. Eur Arch Paediatr Dent. 2021 Apr;22(2):283-290. https://doi.org/10.1007/s40368-020-00555-5
  27. Garot E, Manton D, Rouas P. Peripartum events and molar-incisor hypomineralisation (MIH) amongst young patients in southwest France. Eur Arch Paediatr Dent. 2016 Aug;17(4):245-50. https://doi.org/10.1007/s40368-016-0235-y
  28. Ghanim A, Manton D, Bailey D, Mariño R, Morgan M. Risk factors in the occurrence of molar-incisor hypomineralization amongst a group of Iraqi children. Int J Paediatr Dent. 2013 May;23(3):197-206. https://doi.org/10.1111/j.1365-263X.2012.01244.x
  29. Laisi S, Kiviranta H, Lukinmaa PL, Vartiainen T, Alaluusua S. Molar-incisor-hypomineralisation and dioxins: new findings. Eur Arch Paediatr Dent. 2008 Dec;9(4):224-7. https://doi.org/10.1007/BF03262639
  30. Lygidakis NA, Dimou G, Marinou D. Molar-incisor-hypomineralisation (MIH). A retrospective clinical study in Greek children. II. Possible medical aetiological factors. Eur Arch Paediatr Dent. 2008 Dec;9(4):207-17. https://doi.org/10.1007/BF03262637
  31. Mohamed RN, Basha S, Al-Thomali Y, Al Zahrani FS, Ashour AA, Al Shamrani AS, Almutair NE. Frequency of molar incisor hypomineralization and associated factors among children with special health care needs. Ann Saudi Med. 2021 Jul-Aug;41(4):238-245. https://doi.org/10.5144/0256-4947.2021.238
  32. Noor Mohamed R, Basha S, Virupaxi SG, Idawara Eregowda N, Parameshwarappa P. Hypomineralized Primary Teeth in Preterm Low Birth Weight Children and Its Association with Molar Incisor Hypomineralization-A 3-Year-Prospective Study. Children (Basel). 2021 Dec 2;8(12):1111. https://doi.org/10.3390/children8121111
  33. Nørrisgaard PE, Haubek D, Kühnisch J, Chawes BL, Stokholm J, Bønnelykke K, Bisgaard H. Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial. JAMA Pediatr. 2019 Oct 1;173(10):924-930. https://doi.org/10.1001/jamapediatrics.2019.2545
  34. Owlia F, Akhavan-Karbassi MH, Rahimi R. Could Molar-Incisor Hypomineralization (MIH) Existence be Predictor of Short Stature? Int J Prev Med. 2020 Jul 9;11:101. https://doi.org/10.4103/ijpvm.IJPVM_459_18
  35. Pascon T, Barbosa AMP, Cordeiro RCL, Bussaneli DG, Prudencio CB, Nunes SK, Pinheiro FA, Bossolan G, Oliveira LG, Calderon IMP, Marini G, Rudge MVC. Prenatal exposure to gestational diabetes mellitus increases developmental defects in the enamel of offspring. PLoS One. 2019 Feb 27;14(2):e0211771. https://doi.org/10.1371/journal.pone.0211771
  36. Pitiphat W, Luangchaichaweng S, Pungchanchaikul P, Angwaravong O, Chansamak N. Factors associated with molar incisor hypomineralization in Thai children. Eur J Oral Sci. 2014 Aug;122(4):265-70. https://doi.org/10.1111/eos.12136
  37. Rai A, Singh A, Menon I, Singh J, Rai V, Aswal GS. Molar Incisor Hypomineralization: Prevalence and Risk Factors Among 7-9 Years Old School Children in Muradnagar, Ghaziabad. Open Dent J. 2018 Sep 28;12:714-722. https://doi.org/10.2174/1745017901814010714
  38. Sönmez H, Yıldırım G, Bezgin T. Putative factors associated with molar incisor hypomineralisation: an epidemiological study. Eur Arch Paediatr Dent. 2013 Dec;14(6):375-80. https://doi.org/10.1007/s40368-013-0012-0
  39. Tourino LF, Corrêa-Faria P, Ferreira RC, Bendo CB, Zarzar PM, Vale MP. Association between Molar Incisor Hypomineralization in Schoolchildren and Both Prenatal and Postnatal Factors: A Population-Based Study. PLoS One. 2016 Jun 9;11(6):e0156332. https://doi.org/10.1371/journal.pone.0156332
  40. van der Tas JT, Elfrink MEC, Heijboer AC, Rivadeneira F, Jaddoe VWV, Tiemeier H, Schoufour JD, Moll HA, Ongkosuwito EM, Wolvius EB, Voortman T. Foetal, neonatal and child vitamin D status and enamel hypomineralization. Community Dent Oral Epidemiol. 2018 Aug;46(4):343-351. https://doi.org/10.1111/cdoe.12372
  41. Verma S, Dhinsa K, Tripathi AM, Saha S, Yadav G, Arora D. Molar Incisor Hypomineralization: Prevalence, Associated Risk Factors, Its Relation with Dental Caries and Various Enamel Surface Defects in 8-16-year-old Schoolchildren of Lucknow District. Int J Clin Pediatr Dent. 2022 Jan-Feb;15(1):1-8. https://doi.org/10.5005/jp-journals-10005-2088
  42. Проняева А.И. и др. (2011) Проняева А. И., Косырева Т. Ф. Факторы, влияющие на распространенность молярно-резцовой гипоминерализации // Здоровье и образование в XXI веке. -2011. -№4. - С.397-398. [Pronyaeva A.I. i dr. (2011) Pronyaeva A. I., Kosyreva T. F. Faktory, vliyayushchie na rasprostranennost' molyarno-rezcovoj gipomineralizacii // Zdorov'e i obrazovanie v XXI veke. 2011; 4: 397-398 (In Russ.)]
  43. Jiménez-Farfán D, Guevara J, Zenteno E, Hernández-Guerrero JC. Alteration of the sialylation pattern of the murine tooth germ after ethanol exposure. Birth Defects Res A Clin Mol Teratol. 2005 Dec;73(12):980-8. https://doi.org/10.1002/bdra.20198
  44. Alam M, Raza SJ, Sherali AR, Akhtar AS. Neonatal complications in infants born to diabetic mothers. J Coll Physicians Surg Pak. 2006 Mar;16(3):212-5. Erratum in: J Coll Physicians Surg Pak. 2006 Aug;16(8):566.
  45. Ford D, Seow WK, Kazoullis S, Holcombe T, Newman B. A controlled study of risk factors for enamel hypoplasia in the permanent dentition. Pediatr Dent. 2009 Sep-Oct;31(5):382-8.
  46. Wuollet E, Laisi S, Salmela E, Ess A, Alaluusua S. Molar-incisor hypomineralization and the association with childhood illnesses and antibiotics in a group of Finnish children. Acta Odontol Scand. 2016 Jul;74(5):416-22. https://doi.org/10.3109/00016357.2016.1172342
  47. Roberton NR, Smith MA. Early neonatal hypocalcaemia. Arch Dis Child. 1975 Aug;50(8):604-9. https://doi.org/10.1136/adc.50.8.604
  48. Aine L, Backström MC, Mäki R, Kuusela AL, Koivisto AM, Ikonen RS, Mäki M. Enamel defects in primary and permanent teeth of children born prematurely. J Oral Pathol Med. 2000 Sep;29(8):403-9. https://doi.org/10.1034/j.1600-0714.2000.290806.x
  49. Bensi C, Costacurta M, Belli S, Paradiso D, Docimo R. Relationship between preterm birth and developmental defects of enamel: A systematic review and meta-analysis. Int J Paediatr Dent. 2020 Nov;30(6):676-686. https://doi.org/10.1111/ipd.12646
  50. Futrakul S, Praisuwanna P, Thaitumyanon P. Risk factors for hypoxic-ischemic encephalopathy in asphyxiated newborn infants. J Med Assoc Thai. 2006 Mar;89(3):322-8.
  51. Trotman H, Henny-Harry C. Factors associated with extreme hyperbilirubinaemia in neonates at the University Hospital of the West Indies. Paediatr Int Child Health. 2012 May;32(2):97-101. https://doi.org/10.1179/2046905512Y.0000000014
  52. Hansen AK, Wisborg K, Uldbjerg N, Henriksen TB. Risk of respiratory morbidity in term infants delivered by elective caesarean section: cohort study. Br Med J. 2008;336(7635):85-7.
  53. Cyna AM, Andrew M, Emmett RS, Middleton P, Simmons SW. Techniques for preventing hypotension during spinal anaesthesia for caesarean section. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD002251. https://doi.org/.1002/14651858.CD002251.pub2
  54. Balki M, Carvalho JC. Intraoperative nausea and vomiting during cesarean section under regional anesthesia. Int J Obstet Anesth. 2005 Jul;14(3):230-41. https://doi.org/10.1016/j.ijoa.2004.12.004
  55. Narkevich A.N., Vinogradov K.A. The most common mistakes made by researchers in presenting research results // Ekologiya cheloveka (Human Ecology). - 2020. - Vol. 27. - N. 8. - P. 55-64. (In Russ.). https://doi.org/10.33396/1728-0869-2020-8-55-64
  56. Narkevich A.N., Vinogradov K.A. The most common errors in medical research // Ekologiya cheloveka (Human Ecology). - 2020. - Vol. 27. - N. 7. - P. 59-64. (In Russ.). https://doi.org/10.33396/1728-0869-2020-7-59-64

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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