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Application of hirudotherapy in the complex treatment of periodontal diseases
- Authors: Abdullayeva A.I.1, Bozhedomov A.Y.1, Pustovaya E.P.2, Slonova V.M.2, Karnaeva A.S.2, Kozhevnikova L.A.2
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Affiliations:
- Pirogov Russian National Research Medical University of the Ministry of Health of Russia
- Peoples' Friendship University of Russia (RUDN)
- Issue: Vol 24, No 4 (2020)
- Pages: 273-277
- Section: Reviews
- URL: https://rjdentistry.com/1728-2802/article/view/55297
- DOI: https://doi.org/10.17816/1728-2802-2020-24-4-273-277
- ID: 55297
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Abstract
This article reviews research data on the etiology, pathogenesis, and features of inflammatory periodontal diseases, the possibilities of using hirudotherapy to treat this group of diseases, and the mechanisms of action of this method. The literature search was conducted using the databases Scopus, Web of Science, MedLine, and Global Health. The mechanisms by which medical leeches influence the human body were analyzed.
It is known that the progression of inflammatory periodontal diseases depends on risk factors such as age, smoking, gender, socio-economic factors, and some systemic diseases. The main features of chronic and acute periodontitis are periodontal pockets accompanying the loss of bone mass and attachment of the tooth to the alveolar process, which occur unevenly throughout the dentition. The decisive factor in inflammatory periodontal diseases is the presence of microorganisms. Hirudotherapy is a treatment method using the medical leech Hirudo medicinalis. In their secretion, leeches have more than 20 bioactive molecules with various effects. Their therapeutic mechanisms include six subtypes: a decrease in the content of cellular elements and neutrophils in mixed saliva, normalization of the microflora of the periodontal pocket, and an increase in the number of lactobacilli. The treatment method using leeches leads to a decrease in the depth of the periodontal pockets, normalization of the periodontal index, and tooth mobility. Hirudotherapy leads to a noticeable improvement in the clinical condition of periodontal tissues, is convenient to perform, affordable, and can be recommended for use in the practice of periodontists.
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About the authors
A. I. Abdullayeva
Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Email: valeri99@bk.ru
Russian Federation, 117997, Moscow
A. Y. Bozhedomov
Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Email: valeri99@bk.ru
Russian Federation, 117997, Moscow
Elena P. Pustovaya
Peoples' Friendship University of Russia (RUDN)
Author for correspondence.
Email: valeri99@bk.ru
Candidate of Medical Sciences, Associate Professor of the Department of Prosthetic Dentistry,
Peoples' Friendship University of Russia (RUDN)
V. M. Slonova
Peoples' Friendship University of Russia (RUDN)
Email: valeri99@bk.ru
Russian Federation, 117198, Moscow
A. S. Karnaeva
Peoples' Friendship University of Russia (RUDN)
Email: valeri99@bk.ru
Russian Federation, 117198, Moscow
L. A. Kozhevnikova
Peoples' Friendship University of Russia (RUDN)
Email: valeri99@bk.ru
Russian Federation, 117198, Moscow
References
- Khader YS, Dauod AS, El Qaderi SS, Alkafajei A, Batayha WQ. Periodontal status of diabetics compared with nondiabetics: a metaanalysis. J. Diabetes Complications. 2006;20(1):59–68. doi: 10.1016/j.jdiacomp.2005.05.006.
- Gotsman, Lotan C, Soskolne WA, Rassovsky S, Pugatsch T, Lapidus L, et al. Periodontal destruction is associated with coronary artery disease and perio-dontal infection with acute coronary syndrome. J. Periodontol. 2007;78(5):849–58. doi: 10.1902/jop.2007.060301.
- Demmer RT, Papapanou PN. Epidemiologic patterns of chronic and aggressive periodontitis. Periodontol 2000. 2010;53:28–44. doi: 10.1111/j.1600-0757.2009.00326.x.
- Kalkwarf KL, Kaldahl WB, Patil KD. Evaluation of furcation region response to periodontal therapy. J. Periodontol. 1988;59(12):794–804. doi: 10.1902/jop.1988.59.12.794.
- Albandar JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988–1994. J. Periodontol. 1999;70(1):13–29. doi: 10.1902/jop.1999.70.1.13.
- Salvi G, Lawrence L, Offenbacher S. Influence of risk factors on the pathogenesis of periodontitis. Periodontol 2000. 1997:14:173–201. doi: 10.1111/j.1600-0757.1997.tb00197.x.
- Karpenko IN, Bulkina NV, Ponukalina EV. Modern ideas about the etiology and pathogenesis of rapidly progressive periodontitis. Arkhiv patologii. 2009;71(1):57–9. (in Russian)
- Hart TC. Genetic risk factors for early-onset periodontitis. J Periodontol. 1996;67 Suppl 3S:355–66. doi: 10.1902/jop.1996.67.3s.355.
- Buunk-Werkhoven Y, Dijkstra-le Clercq M, Verheggen-Udding E, de Jong N, Spreen M. Halitosis and oral health-related quality of life: a case report. Int. J. Dent. Hyg. 2012;10(1):3–8. doi: 10.1111/j.1601-5037.2011.00512.x.
- Tsarinskiy MM. Therapeutic dentistry: a textbook for students of dental faculties, interns and practitioners. [Terapevticheskaya stomatologiya: uchebnik dlya studentov stomatologicheskikh fakul'tetov, vrachey-internov i prakticheskikh vrachey]. Rostov-on-Don: Feniks; 2008. 598 p. (in Russian)
- Tsepov LM, Nikolaev AI, Zhazhkov EN. On the question of the etiology and pathogenesis of inflammatory periodontal diseases. Parodontologiya. 2000;(2):9–13. (in Russian)
- Iordanishvili AK. Diseases of the endodontium, periodontal and oral mucosa. [Zabolevaniya endodonta, parodonta i slizistoy obolochki polosti rta]. Mos-cow: MEDpress-inform; 2008. 344 p. (in Russian)
- Popkov VI. Periodontal disease. Complex treatment and prevention: Тextbook. [Zabolevaniya parodonta. Kompleksnoe lechenie i profilaktika: Uchebnoe posobie]. Krasnodar: EDVI; 2010. 172 p. (in Russian)
- Sivovol SI. Primary factors in the etiology and pathogenesis of inflammatory periodontal diseases. Stomatolog. 2006;(6):37–48. (in Russian)
- Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann. Periodontol. 1999;4(1):1–6. doi: 10.1902/annals.1999.4.1.1.
- Giannobile WV, KornmanKS., Williams RC. Personalized medicine enters dentistry. J. Am. Dent. Assoc. 2013;144(8):874–6. doi: 10.14219/jada.archive.2013.0200.
- Usova NF. Inflammatory periodontal diseases: pathogenesis, principles of complex treatment. Sibirskiy meditsinskiy zhurnal (Irkutsk). 2013;116(1):141–4. (in Russian)
- Tsepov LM, Nikolaev AI. Diagnostics, treatment and prevention of periodontal diseases. [Diagnostika, lechenie i profilaktika zabolevaniy parodonta]. Mos-cow: MEDpress-inform; 2008. 272 p. (in Russian)
- Everett FG, Waerhaug J, Widman A. Leonard Widman: surgical treatment of pyorrhea alveolaris. J. Periodontol. 1971;42(9):571–9. doi: 10.1902/jop.1971.42.9.571.
- Munshi Y, Ara I, Rafique H, Ahmad Z. Leeching in the history — a review. Pak. J. Biol. Sci. 2008;11(13):1650–3. doi: 10.3923/pjbs.2008.1650.1653.
- Klimovich LV. History and scientific justification of hirudotherapy. Meditsina neotlozhnykh sostoyaniy. 2012;(7–8):58–62. (in Russian)
- Cherniack EP. Bugs as drugs, part two: worms, leeches, scorpions, snails, ticks, centipedes, and spiders. Altern. Med. Rev. 2011;16(1):50–8.
- Baskova IP, Zavalova LV. Proteinase inhibitors from the medicinal leech Hirudo medicinalis. Biokhimiya. 2001;(66):703–14. (in Russian)
- Abdullah S, Dar LM, Rashid A, Tewari A. Hirudotherapy/leech therapy: applications and indications in surgery. Arch. Clin. Exp. Surg. 2012;(1):172–80.
- Campos IT, Silva MM, Azzolini SS, Souza AF, Sampaio CA, Fritz H. Evaluation of phage display system and leech-derived tryptase inhibitor as a tool for understanding the serine proteinase specificities. Arch. Biochem. Biophys. 2004;425(1):87–94. doi: 10.1016/j.abb.2004.03.004.
- Gronwald W, Bomke J, Maurer T, et al. Structure of the leech protein saratin and characterization of its binding to collagen. J. Mol. Biol. 2008;381(4):913–27. doi: 10.1016/j.jmb.2008.06.034.
- Herlin C, Bertheuil N, Bekara F, Boissiere F, Sinna R, Chaput B. Leech therapy in flap salvage: systematic review and practical recommendations. Ann. Chir. Plast. Esthet. 2016;62(2):e1-e13. doi: 10.1016/j.anplas.2016.06.004.
- Moser M, Auerswald E, Mentele R, Eckerskorn C, Fritz H, Fink E. Bdellastasin, a serine protease inhibitor of the antistasin family from the medical leech (Hirudomedicinalis). Eur. J. Biochem. 1998;253(1):212–20. doi: 10.1046/j.1432-1327.1998.2530212.x.
- Baskova IP, Borodin VG, Seleznev KG. Hirudotherapy: Methodological recommendations for practitioners. [Girudoterapiya: Metodicheskie rek-omendatsii dlya prakticheskikh vrachey]. Moscow: -INSOFT; 1990. 189 p. (in Russian)
- Khramova EYu. Hirudotherapy. Treatment with leeches. [Girudoterapiya. Lechenie piyavkami]. Moscow; 2010. 352 p. (in Russian)
- Fenollar F, Fournier PE, Legre R. Unusual case of Aeromonassobria cellulitis associated with the use of leeches. Eur. J. Clin. Microbiol. Infect. Dis. 1999;18(1):72–3. doi: 10.1007/s100960050232.
- Nikonov GI. Hirudotherapy and hirudopharmacotherapy. [Girudoterapiya i girudofarmakoterapiya]. St. Petersburg: Ves'; 2000. 125 p. (in Russian)
- Kamenev OYu, Baranovskiy AYu. Medical leeches. Theory and Practice: Guide for physicians. [Meditsinskie piyavki. Teoriya i praktika: Rukovodstvo dlya vrachey]. St. Petersburg: Ves'; 2006. 356 p. (in Russian)
- Zyryanova MM, Chesnokova OV. The use of hirudotherapy in the complex treatment of periodontal diseases. In: XIX final scientific conference of young scientists: Proceedings. [XIX itogovaya nauchnaya konferentsiya molodykh uchenykh: Sbornik]. Stavropol: Izdatel'stvo StGMA; 2011:129–30. (in Russian)
- Kutsevlyak VF, Tsiganova NB, Veligorya IE. Hirudotherapy in dentistry. [Girudoterapiya v stomatologii]. Harkov; 2006. 43 p. (in Russian)
- Corrêa LL, Oliveira MS, Tavares-Dias M, Ceccarelli PS. Infections of Hypostomus spp. by Trypanosoma spp. and leeches: a study of hematology and record of these hirudineans as potential vectors of these hemoflagellates. Braz. J. Vet. Parasitol. 2016;25(3):299–305. doi: 10.1590/S1984-29612016049.
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